Abstract
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42-induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42-induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ1-42 by inducing autophagy, indicating its potential therapeutic role in AD.
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Yuan, H., Jiang, C., Zhao, J. et al. Euxanthone Attenuates Aβ1–42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci 66, 512–523 (2018). https://doi.org/10.1007/s12031-018-1175-2
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DOI: https://doi.org/10.1007/s12031-018-1175-2