Association Study of VMAT1 Polymorphisms and Suicide Behavior
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Genetic association studies have linked suicide behavior with genes encoding transporters of monoamine. Variants in the vesicular monoamine transporter 1 (VMAT1) have been previously shown to be associated with several psychiatric disorders including schizophrenia and bipolar disorder. However, their association with suicide behavior has not been explored. In the present study, we genotyped three single-nucleotide polymorphisms (rs2270637, rs1390938, and rs2279709) within this gene in 100 individuals who attempted suicide, 236 suicide victims, and 300 control subjects without any history of psychiatric disorders or suicide ideation. We demonstrated no difference in genotype, allele, or haplotype frequencies of theses single-nucleotide polymorphisms between the study groups. Consequently, contribution of VMAT1 in risk of psychiatric disorders might be independent of suicide behavior. Future studies with larger sample sizes are needed to confirm our results.
KeywordsVMAT1 Suicide SNP
This study was financially supported by grant number 10227 Shahid Beheshti University of Medical Sciences.
Compliance with Ethical Standards
This study was in compliance with ethical committee of Shahid Beheshti University of Medical Sciences(IR.SBMU. MSP.REC.1396.99).
The study protocol was approved by the local ethic committee. Written informed consent was obtained from study participants or their guardians.
- Dean A, Sullivan K, Soe M (2009) Open source epidemiologic statistics for public health, version. Updated 2009/19/09. Available from: http://www.openepi.com.(10 Nov 2010)
- Lohoff FW, Hodge R, Narasimhan S, Nall A, Ferraro TN, Mickey BJ, Heitzeg MM, Langenecker SA, Zubieta JK, Bogdan R, Nikolova YS, Drabant E, Hariri AR, Bevilacqua L, Goldman D, Doyle GA (2014) Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing. Mol Psychiatry 19:129–139CrossRefPubMedGoogle Scholar
- Vaht M, Kiive E, Veidebaum T, Harro J (2016) A functional vesicular monoamine transporter 1 (VMAT1) gene variant is associated with affect and the prevalence of anxiety, affective, and alcohol use disorders in a longitudinal population-representative birth cohort study. Int J Neuropsychopharmacol, 19Google Scholar