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Serologic Markers of Autism Spectrum Disorder

Abstract

According to WHO data, about 67 million people worldwide are affected by autism, and this number grows by 14% annually. Among the possible causes of autism are genetic modifications, organic lesions of the central nervous system, metabolic disorders, influence of viral and bacterial infections, chemical influence to the mother’s body during pregnancy, etc. The conducted research shows that research papers published until today do not name any potential protein markers that meet the requirements of the basic parameters for evaluating the efficiency of disease diagnostics, in particular high sensitivity, specificity, and accuracy. Conducting proteomic research on a big scale in order to detect serologic markers of protein nature associated with development of autism spectrum disorders seems to be highly relevant.

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Acknowledgments

The study was carried out with the financial support of the Russian Science Foundation (grant no. 14-25-00132).

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Correspondence to Anna L. Kaysheva.

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Khramova, T.V., Kaysheva, A.L., Ivanov, Y.D. et al. Serologic Markers of Autism Spectrum Disorder. J Mol Neurosci 62, 420–429 (2017). https://doi.org/10.1007/s12031-017-0950-9

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  • DOI: https://doi.org/10.1007/s12031-017-0950-9

Keywords

  • Autism spectrum disorders
  • Protein markers
  • Mass spectrometry
  • Protein detection