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The Importance of VEGF-KDR Signaling Pathway Genes should Not Be Ignored When the Risk of Developing Multiple Sclerosis is Taken into Consideration

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Abstract

Vascular endothelial growth factor (VEGF) and its receptor kinase insert domain-containing receptor (KDR) pathway trigger the process of angiogenesis as well as inflammation, which contributes to the development and progression of demyelinating lesions in multiple sclerosis. This work is a case–control study comprising of a total of 400 subjects with multiple sclerosis and 400 healthy controls. Participants were subjected to neurological examination and peripheral blood sampling for genotyping. Polymorphisms in the VEGF and KDR genes were assessed using the restriction fragment length polymorphism (RFLP-PCR) method. A significantly higher frequency of the T allele and TT genotype of the VEGF 936C > T (rs3025039) polymorphism was found in the multiple sclerosis group than in the healthy control group (P = 0.01 [OR = 1.41] and P = 0.01 [OR = 3.12], respectively). In addition, VEGF 936C  >  T showed an association with patients in a recessive model. However, the KDR -604T > C (rs2071559) polymorphism showed no significant difference in either allelic or genotype frequency between the two groups. Taken together, the results of the present study suggests that the T allele of the rs3025039 in VEGF gene could be considered a risk factor for developing multiple sclerosis in the Iranian population.

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Acknowledgements

This study was supported financially by the Hamadan University of Medical Sciences (grant no. 950221643).

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Authors and Affiliations

  1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Mehrdokht Mazdeh, Alireza Komaki & Mohammad Mahdi Eftekharian

  2. Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran

    Mehrdokht Mazdeh

  3. Young Researchers and Elite Club, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

    Rezvan Noroozi

  4. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 8th Floor, SBUMS Bldg., Next to Ayatollah Taleghani Hospital, Evin, Tehran, 198396-3113, Iran

    Jalal Gharesouran, Arezou Sayad, Mohsen Habibi, Mehdi Toghi & Mohammad Taheri

  5. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Jalal Gharesouran

  6. Urogenital Stem Cell Research Center, No 23, Shahid Labbafi Nejad Educational Hospital, Shahid Beheshti University of Medical Sciences, Amir Ebrahimi St, Pasdaran Ave, Tehran, Iran

    Mohammad Taheri

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  1. Mehrdokht Mazdeh
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  2. Rezvan Noroozi
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Correspondence to Mohammad Taheri.

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Mazdeh, M., Noroozi, R., Gharesouran, J. et al. The Importance of VEGF-KDR Signaling Pathway Genes should Not Be Ignored When the Risk of Developing Multiple Sclerosis is Taken into Consideration. J Mol Neurosci 62, 73–78 (2017). https://doi.org/10.1007/s12031-017-0912-2

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  • DOI: https://doi.org/10.1007/s12031-017-0912-2

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