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Delivery of Fluorescent Nanoparticles to the Brain

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Abstract

Nanotechnology applications in neuroscience promises to deliver significant scientific and technological breakthroughs, providing answers to unresolved questions regarding the processes occurring in the brain. In this perspective, we provide a short background on two distinct fluorescent nanoparticles and summarize several studies focussed on achieving delivery of these into the brain and their interaction with brain tissue. Furthermore, we discuss challenges and opportunities for further development of nanoparticle-based therapies for targeting delivery of drugs across the blood-brain barrier.

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Acknowledgments

O.S. and B.S. are the recipients of an NHMRC-ARC Dementia Research Fellowships (APP1101258 and APP1111611). The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.

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Authors and Affiliations

  1. School of Mathematical and Physical Sciences, University of Technology Sydney, P.O. Box 123, Broadway, Sydney, NSW, 2007, Australia

    Olga Shimoni

  2. Department of Biomedical Science, Faculty of Medicine and Health Science, Macquarie University, Sydney, NSW, 2109, Australia

    Bingyang Shi

  3. The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia

    Paul A. Adlard & Ashley I. Bush

Authors
  1. Olga Shimoni
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  2. Bingyang Shi
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  3. Paul A. Adlard
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  4. Ashley I. Bush
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Correspondence to Olga Shimoni.

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Shimoni, O., Shi, B., Adlard, P.A. et al. Delivery of Fluorescent Nanoparticles to the Brain. J Mol Neurosci 60, 405–409 (2016). https://doi.org/10.1007/s12031-016-0833-5

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  • DOI: https://doi.org/10.1007/s12031-016-0833-5

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