Delivery of Fluorescent Nanoparticles to the Brain
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Nanotechnology applications in neuroscience promises to deliver significant scientific and technological breakthroughs, providing answers to unresolved questions regarding the processes occurring in the brain. In this perspective, we provide a short background on two distinct fluorescent nanoparticles and summarize several studies focussed on achieving delivery of these into the brain and their interaction with brain tissue. Furthermore, we discuss challenges and opportunities for further development of nanoparticle-based therapies for targeting delivery of drugs across the blood-brain barrier.
KeywordsFluorescent nanoparticles Nanodiamonds Upconversion nanoparticles Blood-brain barrier Multifunctional nanoparticles
O.S. and B.S. are the recipients of an NHMRC-ARC Dementia Research Fellowships (APP1101258 and APP1111611). The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.
- Alawdi SH, El-Denshary ES, Safar MM, Eidi H, David M-O, Abdel-Wahhab MA (2016) Neuroprotective effect of nanodiamond in Alzheimer’s disease rat model: a pivotal role for modulating NF-κB and STAT3 signaling molecular neurobiology:1–13Google Scholar
- Aramesh M, Shimoni O, Ostrikov K, Prawer S, Cervenka J (2015b) Surface charge effects in protein adsorption on nanodiamonds. Nanoscale 7:5726–5736Google Scholar
- Chang H-C (2010) Development and use of fluorescent nanodiamonds as cellular markers. In: Nanodiamonds. Springer, pp 127–150Google Scholar
- Xi G et al. (2013) Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment. Nanomedicine: Nanotechnology, Biology and Medicine 10:381–391Google Scholar
- Yokel RA (2016) Physicochemical properties of engineered nanomaterials that influence their nervous system distribution and effects. Nanomedicine: Nanotechnology, Biology and Medicine 12:2081–2093Google Scholar