Journal of Molecular Neuroscience

, Volume 60, Issue 3, pp 405–409 | Cite as

Delivery of Fluorescent Nanoparticles to the Brain

  • Olga ShimoniEmail author
  • Bingyang Shi
  • Paul A. Adlard
  • Ashley I. Bush


Nanotechnology applications in neuroscience promises to deliver significant scientific and technological breakthroughs, providing answers to unresolved questions regarding the processes occurring in the brain. In this perspective, we provide a short background on two distinct fluorescent nanoparticles and summarize several studies focussed on achieving delivery of these into the brain and their interaction with brain tissue. Furthermore, we discuss challenges and opportunities for further development of nanoparticle-based therapies for targeting delivery of drugs across the blood-brain barrier.


Fluorescent nanoparticles Nanodiamonds Upconversion nanoparticles Blood-brain barrier Multifunctional nanoparticles 



O.S. and B.S. are the recipients of an NHMRC-ARC Dementia Research Fellowships (APP1101258 and APP1111611). The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.School of Mathematical and Physical SciencesUniversity of Technology SydneySydneyAustralia
  2. 2.Department of Biomedical Science, Faculty of Medicine and Health ScienceMacquarie UniversitySydneyAustralia
  3. 3.The Florey Institute for Neuroscience and Mental HealthThe University of MelbourneParkvilleAustralia

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