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Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in South Eastern of Iran

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Abstract

Multiple sclerosis is one of the most widespread demyelinating diseases of the central nervous system. Environmental and genetic factors are collaborating in triggering MS. The role of vitamin D receptor (VDR) gene and its polymorphisms are highlighted as susceptible components. The aim of the present study was to examine the association of single nucleotide polymorphism (SNP)—BsmI and FokI—in VDR gene and MS susceptibility in the South Eastern Iranian population. Therefore, 113 MS patients and 122 controls were recruited in the study. Restriction fragment length polymorphism was performed to detect the SNPs. There were no significant differences in the polymorphism of FokI (rs2228570) in VDR gene among patients and controls (P > 0.05), while a significant difference was observed in BsmI (rs1544410) polymorphism in healthy subjects and homozygous genotype-b/b- with MS (P = 0.025). Results showed a protective association of homozygous genotype-b/b- of BsmI with MS susceptibility in a population in South Eastern of Iran.

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Acknowledgments

The authors thank the MS patients and normal controls for participating in this study.

Conflict of Interests

The authors declare that there is no conflict of interests.

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Authors and Affiliations

  1. Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Mehrnaz Narooie-Nejad

  2. Department of Genetics, Zahedan University of Medical Sciences, Zahedan, Iran

    Mehrnaz Narooie-Nejad

  3. Department of Biology, Sistan and Baluchestan University, Zahedan, Iran

    Maryam Moossavi & Adam Torkamanzehi

  4. Department of Neurology, Zahedan University of Medical Sciences, Zahedan, Iran

    Ali Moghtaderi

  5. Department of Clinical Biochemistry, Zahedan University of Medical Sciences, Zahedan, Iran

    Saeedeh Salimi

  6. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Saeedeh Salimi

Authors
  1. Mehrnaz Narooie-Nejad
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  2. Maryam Moossavi
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  3. Adam Torkamanzehi
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  4. Ali Moghtaderi
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  5. Saeedeh Salimi
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Corresponding authors

Correspondence to Maryam Moossavi or Ali Moghtaderi.

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Narooie-Nejad, M., Moossavi, M., Torkamanzehi, A. et al. Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in South Eastern of Iran. J Mol Neurosci 56, 572–576 (2015). https://doi.org/10.1007/s12031-015-0513-x

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  • DOI: https://doi.org/10.1007/s12031-015-0513-x

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