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Brain Network Activation (BNA) Reveals Scopolamine-Induced Impairment of Visual Working Memory

Journal of Molecular Neuroscience volume 54, pages 59–70 (2014)Cite this article

Abstract

The overarching goal of this event-related potential (ERP) study was to examine the effects of scopolamine on the dynamics of brain network activation using a novel ERP network analysis method known as Brain Network Activation (BNA). BNA was used for extracting group-common stimulus-activated network patterns elicited to matching probe stimuli in the context of a delayed matching-to-sample task following placebo and scopolamine treatments administered to healthy participants. The BNA extracted networks revealed the existence of two pathophysiological mechanisms following scopolamine, disconnection, and compensation. Specifically, weaker frontal theta and parietal alpha coupling was accompanied with enhanced fronto-centro-parietal theta activation relative to placebo. In addition, using the characteristic BNA network of each treatment as well as corresponding literature-guided selective subnetworks as combined biomarkers managed to differentiate between individual responses to each of the treatments. Behavioral effects associated with scopolamine included delayed response time and impaired response accuracy. These results indicate that the BNA method is sensitive to the effects of scopolamine on working memory and that it may potentially enable diagnosis and treatment assessment of dysfunctions associated with cholinergic deficiency.

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Acknowledgments

We would like to thank Prof. Leon Y. Deouell for his helpful comments and discussions. Amit Reches, Ilan Laufer, Revital Shani-Hershkovitch, Keren Ziv, Dani Kerem, Noga Gal, Yaki Stern, Guy Cukierman, and Amir B. Geva are employees of ElMindA Ltd., Herzliya, Israel. This study is part of ElMindA’s Brain Disorders Management and Imaging Technology program which is supported by the Office of the Chief Scientist (OCS), Israel.

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Authors and Affiliations

  1. ElMindA Ltd, Haminhara 16 St, Herzliya, Israel, 46586

    Amit Reches, Ilan Laufer, Revital Shani-Hershkovitch, Keren Ziv, Dani Kerem, Noga Gal, Yaki Stern, Guy Cukierman & Amir B. Geva

  2. INC Research, Toronto, Ontario, Canada

    Naama Levy-Cooperman

  3. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

    Myroslava K. Romach & Edward M. Sellers

  4. DL Global Partners Inc, Toronto, Ontario, Canada

    Myroslava K. Romach & Edward M. Sellers

  5. Electrical and Computer Engineering, Ben Gurion University of the Negev, Beersheba, Israel

    Amir B. Geva

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  1. Amit Reches
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  2. Naama Levy-Cooperman
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Reches, A., Levy-Cooperman, N., Laufer, I. et al. Brain Network Activation (BNA) Reveals Scopolamine-Induced Impairment of Visual Working Memory. J Mol Neurosci 54, 59–70 (2014). https://doi.org/10.1007/s12031-014-0250-6

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  • DOI: https://doi.org/10.1007/s12031-014-0250-6

Keywords

  • Brain Network Activation (BNA)
  • Scopolamine
  • Cholinergic hypothesis
  • Working memory (WM)
  • Dementia
  • Event-related potentials (ERPs)