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The Effect of Vitamin A Supplementation on Retinoic Acid-Related Orphan Receptor γt (RORγt) and Interleukin-17 (IL-17) Gene Expression in Avonex-Treated Multiple Sclerotic Patients

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Abstract

The aim of this study was to investigate the role of vitamin A on RORγt and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and RORγt gene expression. No changes in gene expression occurred in the placebo group.

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Acknowledgments

This study was carried out at Tehran University of Medical Sciences (TUMS), Health Services grants, School of Nutritional Science and Dietetics, and the Iranian Center for Neurological Research (ID: 10033). It was registered according to the appropriate clinical trial registration system (NCT01225289).

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Correspondence to Ali Akbar Saboor-Yarghi.

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Mohammadzadeh Honarvar, N., Harirchian, M.H., Koohdani, F. et al. The Effect of Vitamin A Supplementation on Retinoic Acid-Related Orphan Receptor γt (RORγt) and Interleukin-17 (IL-17) Gene Expression in Avonex-Treated Multiple Sclerotic Patients. J Mol Neurosci 51, 749–753 (2013). https://doi.org/10.1007/s12031-013-0058-9

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  • DOI: https://doi.org/10.1007/s12031-013-0058-9

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