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Association Between Genetic Variations of Vascular Endothelial Growth Factor Receptor 2 and Glioma in the Chinese Han Population

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Abstract

Tumor angiogenesis, which is an important step in the development of cancer, is directly regulated by vascular endothelial growth factor receptor 2 (VEGFR-2). In this study, we examined the association of five potentially functional VEGFR-2 polymorphisms with glioma risk in a Chinese Han population. Three SNPs, rs2071559, rs7667298 and rs2305948, showed a statistically significant increased association with the risk of glioma (P = 0.006, 0.005, and 0.012, respectively). Both haplotype and diplotype analyses consistently revealed that subjects carrying two copies of the haplotype “CGT” had a 42% reduced glioma risk compared with their respective noncarriers. Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility.

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Acknowledgments

The authors thank Haishi Zhang and Fengping Huang for subject enrollment. They also thank all staff members of the Department of Neurosurgery of Huashan Hospital for their cooperation during data collection. This work was partially supported by the Natural Science Foundation of China (81001114), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, and the Doctoral Fund of Ministry of Education of China.

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Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China

    Hongyan Chen, Zhao Xingjie, Xiao Song, Weiwei Fan & Daru Lu

  2. Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine Technique, College of Life Sciences, China Jiliang University, Hangzhou, China

    Weimin Wang

  3. Neurosurgery Department of Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd., Shanghai, 200040, China

    Zhou Keke, Gong Chen, Yao Zhao & Ying Mao

Authors
  1. Hongyan Chen
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  2. Weimin Wang
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  3. Zhao Xingjie
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  4. Xiao Song
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  5. Weiwei Fan
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  6. Zhou Keke
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  7. Gong Chen
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  8. Yao Zhao
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  9. Ying Mao
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  10. Daru Lu
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Corresponding authors

Correspondence to Yao Zhao or Ying Mao.

Additional information

Hongyan Chen and Weimen Wang contributed equally to this work.

Yao Zhao and Ying Mao jointly directed the work.

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Chen, H., Wang, W., Xingjie, Z. et al. Association Between Genetic Variations of Vascular Endothelial Growth Factor Receptor 2 and Glioma in the Chinese Han Population. J Mol Neurosci 47, 448–457 (2012). https://doi.org/10.1007/s12031-012-9705-9

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  • DOI: https://doi.org/10.1007/s12031-012-9705-9

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