c-Abl in Neurodegenerative Disease

Abstract

The c-Abl tyrosine kinase participates in a variety of cellular functions, including regulation of the actin cytoskeleton, regulation of the cell cycle, and the apoptotic/cell cycle arrest response to stress, and the Abl family of kinases has been shown to play a crucial role in development of the central nervous system. Recent studies have shown c-Abl activation in human Alzheimer’s and Parkinson’s diseases and c-Abl activation in mouse models and neuronal culture in response to amyloid beta fibrils and oxidative stress. Overexpression of active c-Abl in adult mouse neurons results in neurodegeneration and neuroinflammation. Based on this evidence, a potential role for c-Abl in the pathogenesis of neurodegenerative disease is discussed, and we attempt to place activation of c-Abl in context with other known contributors to neurodegenerative pathology.

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Acknowledgments

Supported by Applied Neurosolutions Inc and by NIMH38623 and AG022102. We thank Dr. Dennis Dickson for the human tauopathy cases used for experiments as shown in Fig. 2.

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Correspondence to Peter Davies.

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Schlatterer, S.D., Acker, C.M. & Davies, P. c-Abl in Neurodegenerative Disease. J Mol Neurosci 45, 445–452 (2011). https://doi.org/10.1007/s12031-011-9588-1

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Keywords

  • Tau
  • Alzheimer’s
  • c-Abl
  • Tyrosine kinase
  • Tauopathy