Abstract
Compare to the thoroughly studied beta-amyloid, the physiological function of amyloid precursor protein (APP) is not well understood. We now had identified neural cell adhesion molecule (NCAM)-140 as a potential interaction partner of APP. Our data indicated that NCAM-140, but not NCAM-180, binds to the conserved central extracellular domain of APP. We also found that the phosphorylation levels of ERK1 and ERK2 were increased when cells were co-transfected with NCAM-140 and APP indicate that the interaction between NCAM-140 and APP may involve the MAPK pathway. These findings demonstrated that NCAM-140 interacts with APP, potentially playing a role in neurite outgrowth and neural development.
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This work was supported by grants from the National Natural Science Foundation of China (NSFC) (30600099) (FD).
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An erratum to this article can be found at http://dx.doi.org/10.1007/s12031-012-9708-6.
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Chen, Kp., Dou, F. Selective Interaction of Amyloid Precursor Protein with Different Isoforms of Neural Cell Adhesion Molecule. J Mol Neurosci 46, 203–209 (2012). https://doi.org/10.1007/s12031-011-9578-3
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DOI: https://doi.org/10.1007/s12031-011-9578-3