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Fyn Polymorphisms are Associated with Distinct Personality Traits in Healthy Chinese-Han Subjects

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Abstract

The Src family tyrosine kinase Fyn regulates a myriad of neurophysiological processes, including learning and memory. To date, the role of Fyn in the neurological mechanisms that determine personality traits has not been addressed. To this end, we determined the association between the rs706895C/T polymorphism of the Fyn gene (FYN) and personality traits measured by the Tridimensional Personality Questionnaire in 502 healthy Chinese-Han subjects. There were no significant differences in the total scores for novelty seeking (χ 2 = 5.12, P = 0.077), harm avoidance (HA; χ 2 = 2.63, P = 0.269), or reward dependence (RD; χ 2 = 3.94, P = 0.139) among the rs706895C/T genotypes. In sub-item analyses, however, both fear of uncertainty (HA2; χ 2 = 7.84, P = 0.020) and sentimentality (RD1; χ 2 = 8.27; P = 0.016) scores were significantly different among rs706895C/T genotypes. Our results suggest that FYN alleles can contribute to the variance in human personality traits.

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Acknowledgements

This study was supported by a Grant from National Natural Science Foundation of China (30400146).

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Authors and Affiliations

  1. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

    Jingying Li, Huan Ma, Lijuan Wu, Yinglin Huang & Gang Zhu

  2. Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

    Shumin Deng

Authors
  1. Jingying Li
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  2. Huan Ma
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  3. Shumin Deng
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  4. Lijuan Wu
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  5. Yinglin Huang
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  6. Gang Zhu
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Corresponding author

Correspondence to Gang Zhu.

Additional information

Jingying Li and Huan Ma contributed equally to this work.

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Li, J., Ma, H., Deng, S. et al. Fyn Polymorphisms are Associated with Distinct Personality Traits in Healthy Chinese-Han Subjects. J Mol Neurosci 44, 1–5 (2011). https://doi.org/10.1007/s12031-010-9485-z

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  • DOI: https://doi.org/10.1007/s12031-010-9485-z

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