Abstract
Recent work has demonstrated that axonal regeneration in the central nervous system is limited by myelinderived Nogo binding to an axonal Nogo Receptor. The Nogo system appears to have a physiologic role in regulating structural plasticity. The possibility that the Nogo system contributes to pathologic and compensatory plasticity in Alzheimer’s Disease is considered.
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Strittmatter, S.M. Modulation of axonal regeneration in neurodegenerative disease. J Mol Neurosci 19, 117–121 (2002). https://doi.org/10.1007/s12031-002-0021-7
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DOI: https://doi.org/10.1007/s12031-002-0021-7