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A dielectrophoretic microchip for controlled cell targeting with functionalized microspheres

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NanoBiotechnology

Abstract

Individual cell manipulation and targeting is of major interest in the field of diagnosis, phenotypic characterization and drug delivery. Lab-on-a-chip technologies open the possibility to work easily at the single cell level. We developed a dielectrophoretic microchip capable to trap and manipulate individual cells and microspheres. We targeted single cells with functionalized microspheres in a software-controlled way proving the efficiency and reliability of our chip. As an example, we demonstrate guided targeting and binding of cell lines expressing or not specific antigens with microspheres coated or not with the corresponding monoclonal antibodies.

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Authors and Affiliations

  1. Silicon Biosystems, Via S. Stefano 132, 40125, Bologna, Italy

    M. Abonnenc, G. Medoro & M. Manaresi

  2. ER-Gen Tech, Department of Biochemistry and Molecular Biology, Ferrara University, Via Savonarola 9/11, 44100, Ferrara, Italy

    M. Borgatti, E. Fabbri, I. Mancini & R. Gambari

  3. ARCES, University of Bologna, Viale C. Pepoli 3/2, 40123, Bologna, Italy

    A. Romani, L. Altomare, M. Tartagni & R. Guerrieri

  4. Biochip Laboratory, CEA, 17 rue des Martyrs, 38054, Grenoble Cedex 9, France

    D. Freida

  5. Department of Pharmaceutical Chemistry and Technology, University of Perugia, Piazza dell’Università I, 06100, Perugia, Italy

    C. Nastruzzi

  6. Department of Experimental and Diagnostic Medicine, Section of Human Genetic, Ferrara University, Via Savonarola 9/11, 44100, Ferrara, Italy

    O. Baricordi & R. Rizzo

Authors
  1. M. Abonnenc
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  2. M. Borgatti
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  3. A. Romani
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  4. L. Altomare
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  5. E. Fabbri
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  6. I. Mancini
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  7. G. Medoro
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  8. D. Freida
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  9. M. Tartagni
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  10. C. Nastruzzi
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  11. R. Gambari
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  12. O. Baricordi
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  13. R. Rizzo
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  14. R. Guerrieri
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  15. M. Manaresi
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Corresponding author

Correspondence to M. Abonnenc.

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Abonnenc, M., Borgatti, M., Romani, A. et al. A dielectrophoretic microchip for controlled cell targeting with functionalized microspheres. Nanobiotechnol 1, 257–259 (2005). https://doi.org/10.1007/s12030-005-0033-9

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  • DOI: https://doi.org/10.1007/s12030-005-0033-9

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