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Prognosis of Mesorectal Tumor Deposits in Patients with Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy and Total Mesorectal Excision

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Abstract

Background

Tumor deposits (TDs) are associated with adverse prognostic factors and decreased survival in colon cancer. However, there is no information of their survival impact in rectal cancer with neoadjuvant chemoradiotherapy (n-CRT).

Methods

Retrospective study in 223 patients with rectal cancer with n-CRT. A survival analysis of factors associated with decreased overall survival (OS) including TDs was performed.

Results

From 223 patients, 131 (58.7%) were men, mean age 59.8 (± 13.06) years, and 42 (18.8%) of them revealed TDs. Survival analysis of TDs showed no association with mortality. Factors associated with decreased 5-year OS were the histologic grade (p = 0.42), perineural invasion (p = 0.001), and mesorectal quality (p = 0.067). Perineural invasion (HR = 2.335, 95% CI = 1.198–4.552) remained as independent factor in the multivariate analysis.

Conclusions

TDs were not associated with mortality in rectal cancer patients treated with n-CRT. Factors associated with decreased survival were inadequate mesorectal quality and perineural invasion.

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Data Availability Statement

The data are available to everyone at request.

References

  1. Amin MB, Edge SB, Greene FL, et al editors. AJCC cancer staging manual. 8th ed. New York: Springer; 2017.

    Google Scholar 

  2. Nagtegaal ID, Quirke P. Colorectal tumour deposits in the mesorectum and pericolon; a critical review. Histopathology. 2007;51(2):141e9.

  3. Lord AC, D’Souza N, Pucher PH, Moran BJ, Abulafi AM, Wotherspoon A, Rasheed S, Brown G. Significance of extranodal tumour deposits in colorectal cancer: a systematic review and meta-analysis. Eur J Cancer. 2017;82(x):92–102.

  4. Gopal P, Lu P, Ayers GD, Herline AJ, Washington MK. Tumor deposits in rectal adenocarcinoma after neoadjuvant chemoradiation are associated with poor prognosis. Mod Pathol. 2014;27(9):1281–7.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Wei XL, Qiu MZ, Zhou YX, et al. The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy. Oncotarget. 2016;7(46):75094–103.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Zhang LN, Xiao WW, Xi SY, et al. Tumor deposits: markers of poor prognosis in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy. Oncotarget. 2016;7(5):6335–44.

    Article  PubMed  Google Scholar 

  7. Lino-Silva LS, García-Gómez MA, Aguilar-Romero JM, et al. Mesorectal pathologic assessment in two grades predicts accurately recurrence, positive circumferential margin, and correlates with survival. J Surg Oncol. 2015;112(8):900–6.

    Article  PubMed  Google Scholar 

  8. Dukes CE. The classification of cancer of the rectum. J Pathol. 1932;35:323–32.

    Article  Google Scholar 

  9. Peparini N, Beyond T. N and M: the impact of tumor deposits on the staging and treatment of colorectal and gastric carcinoma. Surg Oncol. 2018;27(2):129–37.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. General Surgery, Instituto Nacional de Ciencias Médicas Y de La Nutrición Salvador Zubrán, Mexico City, Mexico

    José M. Aguilar-Romero

  2. Colorectal Surgery Division, Instituto Nacional de Ciencias Médicas y de La Nutrición Salvador Zubrán, Mexico City, Mexico

    José M. Aguilar-Romero & Omar Vergara-Fernández

  3. AFINES Program, National Autonomus University of Mexico (UNAM), Mexico City, Mexico

    Estefanía Aguilar-Romero

  4. Surgical Pathology, Instituto Nacional de Cancerología, Av. San Fernando # 22, Sección XVI, Tlalpan, 14080, Mexico City, CP, Mexico

    Estefanía Aguilar-Romero & Leonardo S. Lino-Silva

  5. Surgical Oncology, Hospital Ángeles Tijuana, Tijuana, Baja California Norte, Mexico

    César Zepeda-Najar

  6. Surgical Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico

    Rosa A. Salcedo-Hernández

Authors
  1. José M. Aguilar-Romero
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  2. Estefanía Aguilar-Romero
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  3. Omar Vergara-Fernández
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  4. César Zepeda-Najar
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  5. Leonardo S. Lino-Silva
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  6. Rosa A. Salcedo-Hernández
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Contributions

Conception and design: all authors. Financial support: Leonardo S. Lino-Silva, César Zepeda-Najar. Provision of study materials or patients: all authors. Collection and assembly of data: Leonardo S. Lino-Silva, Omar A. Ruiz-Félix Data analysis (statistical analysis) and interpretation: Leonardo S. Lino-Silva, Rosa A. Salcedo-Hernández. Manuscript writing: all authors Final revision and approval of manuscript: all authors. Guarantor: Leonardo S. Lino-Silva.

Corresponding author

Correspondence to Leonardo S. Lino-Silva.

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All authors meet the criteria for authorship as per the guidelines of the International Committee of Medical Journal Editors (ICMJE).

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The authors declare no competing interests.

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Aguilar-Romero, J.M., Aguilar-Romero, E., Vergara-Fernández, O. et al. Prognosis of Mesorectal Tumor Deposits in Patients with Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy and Total Mesorectal Excision. J Gastrointest Canc 54, 687–691 (2023). https://doi.org/10.1007/s12029-022-00822-2

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  • DOI: https://doi.org/10.1007/s12029-022-00822-2

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