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Antibacterial Activity of Some Medicinal Plants in Al Baha Region, Saudi Arabia, Against Carcinogenic Bacteria Related to Gastrointestinal Cancers

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Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Background

Gastrointestinal cancers are the most dangerous cancers all over the world. The gut microbiota dysbiosis increases the risk of GI cancers and induces the host’s susceptibility to carcinogenic bacteria. Antibiotic resistance is rising in these bacteria. Thus, discovering new safe and effective antibacterial agents is a worldwide concern. This study evaluates the antibacterial activity of six wild medicinal plants from the Al Bahah region in Saudi Arabia.

Methods

Arial parts of Cissus quadrangularis, Aloe castellorum, Psiadia punctulata, Aloe pseudorubroviolacea, Barbeya oleoides, Teucrium yemense were collected and dried for extraction with ethanol. The minimum inhibitory concentrations (MIC) of these ethanolic extracts against carcinogenic bacteria Bacteroides fragilis, Clostridium ssp., Cutibacterium acnes, Escherichia coli, Fusobacterium nucleatum, Helicobacter pylori, Mycoplasma spp., Neisseria gonorrhoeae, Porphyromonas gingivalis, Salmonella enterica, and Treponema pallidum were evaluated to determine its antibacterial activity.

Results

All extracts showed antibacterial activity with MIC lower than 1 mg/ml. Psiadia punctulata showed higher antibacterial activity, while the Aloe species showed the lowest antibacterial activity.

Conclusion

The studied plants’ extracts showed high effectiveness as antibacterial activity against the carcinogenic bacteria related to gastrointestinal cancers due to their high content of pharmaceutical components. These plants could be explored further for the development of new antibacterial products against these carcinogenic bacteria.

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Acknowledgements

The authors extend their appreciation to the Deanship of Higher Studies and Scientific Research, Albaha University, for funding this work through project number 7/1441. The authors gratefully acknowledge this financial support.

Funding

Funding for project number 7/1441 by Deanship of Higher Studies and Scientific Research, Albaha University, Saudi Arabia.

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Authors and Affiliations

  1. Biology Department, Faculty of Science and Arts-Qilwah, Albaha University (BU), Al Bahah, Qilwah, Saudi Arabia

    Abdulrahman Ali Alzandi, Essam Ahmed Taher, Nageeb A. Al-Sagheer & Deyala M. Naguib

  2. Chemistry Department, Faculty of Science and Arts-Qilwah, Albaha University (BU), Al Bahah, Qilwah, Saudi Arabia

    Mohamed Azizi

  3. Lab. Desalination and Water Treatment Valorisation (LaDVEN), Water Research and Technologies Center (WRTC), BP 273, 8020, Soliman, Tunisia

    Mohamed Azizi

  4. Agricultural Research and Extension Authority (AREA), Dhamar, Yemen

    Nageeb A. Al-Sagheer & Abdul Wali Al-Khulaidi

  5. Department of Biology, Faculty of Science and Arts, Albaha University (BU), Baljurashi, Saudi Arabia

    Abdul Wali Al-Khulaidi

  6. Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, Egypt

    Deyala M. Naguib

Authors
  1. Abdulrahman Ali Alzandi
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  2. Essam Ahmed Taher
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  5. Abdul Wali Al-Khulaidi
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  6. Deyala M. Naguib
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Correspondence to Deyala M. Naguib.

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Alzandi, A.A., Taher, E.A., Azizi, M. et al. Antibacterial Activity of Some Medicinal Plants in Al Baha Region, Saudi Arabia, Against Carcinogenic Bacteria Related to Gastrointestinal Cancers. J Gastrointest Canc 54, 51–55 (2023). https://doi.org/10.1007/s12029-021-00793-w

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