Skip to main content

Advertisement

SpringerLink
Log in

Association Between Helicobacter pylori and Periampullary and Pancreatic Cancer: a Case–Control Study

  • Original Research
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 06 December 2022

Abstract

Introduction

Helicobacter pylori has been implicated in the etiopathogenesis of various malignant conditions; however, there is a dearth of studies on the correlation between H. pylori infection and pancreatic cancers. Hence, this study was carried out to evaluate the association between H. pylori infection and periampullary and pancreatic cancer.

Methods

This was a single-centre, retrospective, case–control study in which all consecutive patients of periampullary or pancreatic cancer were included. The demographic details with tumour characteristics were recorded. Age and gender-matched controls were patients with other extra-abdominal benign conditions. H. pylori and the Cag A status were determined using IgG antibodies and Cag A antibodies respectively. The association between H. pylori infection and periampullary and pancreatic cancer was the primary outcome.

Results

A total of 155 patients, 61 in the study and 94 in the control group were included. The overall prevalence of H. pylori in the study group (78.6%) was similar to that of the control group (76.5%) (p = 0.76). Although a higher trend of IgG and Cag A seropositivity was seen in the study group, the difference was not significant. The correlation of H. pylori and Cag A seropositivity showed a higher trend with site-specificity, differentiation, and nodal status. However, the difference was not significant.

Conclusion

There was no association between H. pylori infection and Cag A seropositivity with periampullary and pancreatic cancers. The various tumour characteristics were also not associated with H. pylori infection. Thus, routine eradication of H. pylori infection may not be recommended in periampullary and pancreatic cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Testerman TL, Morris J. Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment. World J Gastroenterol. 2014;20:12781–808.

    Article  CAS  Google Scholar 

  2. Kusters JG, van Vliet AHM, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. American Society for Microbiology (ASM); 2006 [cited 2021 Aug 8];19:449. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539101/.

  3. Risch HA. Pancreatic cancer: Helicobacter pylori colonization, N-nitrosamine exposures, and ABO blood group. Mol Carcinog. 2012;51:109–18.

    Article  CAS  Google Scholar 

  4. Trikudanathan G, Philip A, Dasanu CA, Baker WL. Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis. JOP. 2011;12:26–31.

    Google Scholar 

  5. Lee JY, Park HW, Choi JY, Lee J-S, Koo JE, Chung EJ, et al. Helicobacter pylori infection with atrophic gastritis is an independent risk factor for advanced colonic neoplasm. Gut Liver. 2016 [cited 2021 Aug 25];10:902–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087929/.

  6. Ashokkumar S, Agrawal S, Mandal J, Sureshkumar S, Sreenath GS, Kate V. Hybrid therapy versus sequential therapy for eradication of Helicobacter pylori: a randomized controlled trial. J Pharmacol Pharmacother. Wolters Kluwer — Medknow Publications; 2017 [cited 2021 Jul 27];8:62. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497401/.

  7. Hidalgo M. Pancreatic cancer. N Engl J Med. 2010;362:1605–17.

    Article  CAS  Google Scholar 

  8. Miura F, Takada T, Amano H, Yoshida M, Furui S, Takeshita K. Diagnosis of pancreatic cancer. HPB (Oxford). 2006 [cited 2021 Aug 25];8:337–42. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020745/.

  9. Ai F, Hua X, Liu Y, Lin J, Feng Z. Preliminary study of pancreatic cancer associated with Helicobacter pylori infection. Cell Biochem Biophys. 2015;71:397–400.

    Article  CAS  Google Scholar 

  10. Raderer M, Wrba F, Kornek G, Maca T, Koller DY, Weinlaender G, et al. Association between Helicobacter pylori infection and pancreatic cancer. OCL. Karger Publishers; 1998 [cited 2021 Aug 25];55:16–9. Available from: https://www.karger.com/Article/FullText/11830.

  11. Tomtitchong P, Siribumrungwong B, Vilaichone R-K, Kasetsuwan P, Matsukura N, Chaiyakunapruk N. Systematic review and meta-analysis: Helicobacter pylori eradication therapy after simple closure of perforated duodenal ulcer. Helicobacter. 2012;17:148–52.

    Article  Google Scholar 

  12. Franceschi F, Zuccalà G, Roccarina D, Gasbarrini A. Clinical effects of Helicobacter pylori outside the stomach. Nat Rev Gastroenterol Hepatol. 2014;11:234–42.

    Article  CAS  Google Scholar 

  13. Sibony M, Jones NL. Recent advances in Helicobacter pylori pathogenesis. Curr Opin Gastroenterol. 2012;28:30–5.

    Article  Google Scholar 

  14. Venerito M, Selgrad M, Malfertheiner P. Helicobacter pylori: gastric cancer and extragastric malignancies — clinical aspects. Helicobacter. 2013;18(Suppl 1):39–43.

    Article  Google Scholar 

  15. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22:9694–705.

    Article  Google Scholar 

  16. Sikdar N, Saha G, Dutta A, Ghosh S, Shrikhande SV, Banerjee S. Genetic alterations of periampullary and pancreatic ductal adenocarcinoma: an overview. Curr Genomics. 2018;19:444–63.

    Article  CAS  Google Scholar 

  17. Xiao M, Wang Y, Gao Y. Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis. PLoS One. 2013;8:e75559.

    Article  CAS  Google Scholar 

  18. Hirabayashi M, Inoue M, Sawada N, Saito E, Abe SK, Hidaka A, et al. Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: a population-based cohort study in a large Japanese population: the JPHC Study. Sci Rep. 2019 [cited 2021 Aug 8];9:6099. Available from: https://www.nature.com/articles/s41598-019-42365-w.

  19. Risch HA, Lu L, Kidd MS, Wang J, Zhang W, Ni Q, et al. Helicobacter pylori seropositivities and risk of pancreatic carcinoma. Cancer Epidemiol Biomarkers Prev. 2014;23:172–8.

    Article  CAS  Google Scholar 

  20. Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. The burning question: why is smoking a risk factor for pancreatic cancer? Pancreatology. 2012;12:344–9.

    Article  CAS  Google Scholar 

  21. Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J Oncol. 2019;10:10–27.

    Article  Google Scholar 

  22. Li D. Diabetes and pancreatic cancer. Mol Carcinog. 2012;51:64–74.

    Article  CAS  Google Scholar 

  23. Lee S-W, Chang C-S, Lee T-Y, Yeh H-Z, Tung C-F, Peng Y-C. Risk factors and therapeutic response in Chinese patients with peptic ulcer disease. World J Gastroenterol. 2010;16:2017–22.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry-605006, India

    Giri B. Laya, Amaranathan Anandhi, Balakrishnan Gurushankari & Vikram Kate

  2. Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry-605006, India

    Jharna Mandal

Authors
  1. Giri B. Laya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amaranathan Anandhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Balakrishnan Gurushankari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jharna Mandal
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vikram Kate
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Vikram Kate and A. Anandhi contributed to the conception and design of the research; Vikram Kate contributed to the overall supervision and validation of the work; Giri B Laya contributed to the acquisition and analysis of the data; Vikram Kate, A. Anandhi and Jharna Mandal contributed to the interpretation of the data; Giri B Laya and Balakrishnan Gurushankari drafted and edited the manuscript under supervision. All authors critically revised the manuscript, agree to be fully accountable for ensuring the integrity and accuracy of the work, and read and approved the final manuscript.

Ethics declarations

Competing Interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Laya, G.B., Anandhi, A., Gurushankari, B. et al. Association Between Helicobacter pylori and Periampullary and Pancreatic Cancer: a Case–Control Study. J Gastrointest Canc 53, 902–907 (2022). https://doi.org/10.1007/s12029-021-00766-z

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-021-00766-z

Keywords

Search

Navigation