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Investigating Trends of Incidence Rates of Esophageal Cancer Divided by Squamous Cell Carcinoma and Adenocarcinoma in Southern Iran: a 10-Year Experience

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A Correction to this article was published on 31 January 2022

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Abstract

Background

Gastrointestinal cancers account for a significant number of deaths and new cancer cases worldwide. Our aim is to investigate stratum-specific incidence trends of esophageal cancer in southern Iran considering age, gender, and morphological (adenocarcinoma/squamous cell carcinoma) subtypes.

Method

We used data on esophageal cancer incidence in the catchment area of Shiraz Population-Based Cancer Registry. New cancer cases with ICD-O-3 codes of C15.0 to C15.9 were retrieved and prepared. New annual cases were counted for categories defied based on age group, gender, and morphology. Average annual percentage change (AAPC) and its 95% CI was estimated for each trend using joinpoint regression.

Results

The total number of esophageal cancer was higher in males than females. It is an increasing rate in esophageal adenocarcinoma in females and this increase was more prominent in older ages. Also, our study showed that SCC has a decreasing trend in females and a steady trend in males.

Discussion

Taken together, the increasing trend in adenocarcinoma in females in our study can be related to the increasing rate of obesity and smoking in females in recent years in our region. The incidence trend of different morphologic types of esophageal cancer is changing. This can be a consequence of alterations in the incidence trend of different risk factors. It is necessary to conduct more studies evaluating these risk factors.

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Availability of Data and Material

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This report was extracted from MH’s thesis in MPH.

Funding

The study was funded by the Shiraz University of Medical Sciences.

Author information

Authors and Affiliations

  1. MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Mahnaz Hosseini-Bensenjan

  2. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Mahnaz Hosseini-Bensenjan & Sezaneh Haghpanah

  3. MPH Department, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Hossein Molavi Vardanjani

  4. Shiraz Population-Based Cancer Registry, Shiraz University of Medical Sciences, Shiraz, Iran

    Zahra Khosravizadegan

  5. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, 71348-45794, Shiraz, Iran

    Kamran Bagheri-Lankarani

Authors
  1. Mahnaz Hosseini-Bensenjan
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  2. Hossein Molavi Vardanjani
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  3. Sezaneh Haghpanah
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  4. Zahra Khosravizadegan
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Contributions

K.B.L. proposed the idea and supervised the study; H.M.V. & M.H-B. conceptualized and designed the study, analyzed the data, and revised the manuscript; M.H.-B. conducted data cleaning and data preparation, participated in conceptual frame-working and data analysis, and M.H-B & S.H drafting the manuscript; Z.K. was responsible for data collection and its quality. All authors read the final version of the manuscript.

Corresponding author

Correspondence to Kamran Bagheri-Lankarani.

Ethics declarations

Ethics Approval

The study was approved by the Ethics Committee of Shiraz University of Medical Sciences (Ethics code: IR.SUMS.MED.REC.1398.066).

Consent to Participate

Not applicable.

Consent for Publication

Not applicable.

Conflict of Interest

Z.K. is affiliated with the Shiraz Population-Based Cancer Registry. Other authors declare no conflict of interest.

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The original online version of this article was revised: Sezaneh Haghpanah should only affilated to Hematology Research Center, Shiraz University of medical Sciences, Shiraz, Iran.

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Hosseini-Bensenjan, M., Vardanjani, H.M., Haghpanah, S. et al. Investigating Trends of Incidence Rates of Esophageal Cancer Divided by Squamous Cell Carcinoma and Adenocarcinoma in Southern Iran: a 10-Year Experience. J Gastrointest Canc 53, 230–234 (2022). https://doi.org/10.1007/s12029-021-00764-1

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