Abstract
Background
Krukenberg tumors are among rare cases of metastatic ovary cancers. They are presented as a solid mass which generally has bilateral and sometimes cystic components and is also known through symptoms related to the mass effect and/or hormonal imbalance. However, they may present findings before the primary tumor or remain asymptomatic for a long time.
Case Report
We presented a patient, who was diagnosed with gallbladder cancer nine years ago and whose adjuvant treatment was completed, applied to the outpatient clinic with the complaint of vaginal bleeding. Surgery was recommended to the patient and the patient was diagnosed with metastatic signet ring cell gallbladder cancer. The patient was started on gemcitabine-capecitabine treatment after surgery.
Conclusion
The case is important both due to the rareness of metastasis of gall bladder cancer on the ovaries and also the detection of metastasis following the nine-year recurrence-free period. This case shows that routine controls including a careful gynecological examination in a patient primarily detected to have gastrointestinal malignity are important for recognizing late metastases.
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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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References
Foster JM, Hoshi H, Gibbs JF, Iyer R, Javle M, Chu Q, et al. Gallbladder cancer: defining the indications for primary radical resection and radical re-resection. Ann Surg Oncol. 2007;14(2):833–40.
Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99.
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010;362(14):1273–81.
Krukenberg F. Ueber das Fibrosarcoma ovarii mucocellulare (carcinomatodes). Arch Gynakol. 1896;50(2):287–321.
Małgorzata J, Janusz E. Krukenberg tumor–8 years after surgical treatment of gastric carcinoma. Ginekol Pol. 2008;79(8):564–6.
Agnes A, Biondi A, Ricci R, Gallotta V, D’Ugo D, Persiani R. Krukenberg tumors: seed, route and soil. Surg Oncol. 2017;26(4):438–45.
Kiyokawa T, Young RH, Scully RE. Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol. 2006;30(3):277–99.
Pesce A, Destri GL, Amore FF, Magro G, La Greca G, Puleo S. A rare case of Krukenberg tumor by gallbladder cancer. Annals of Medicine and Surgery. 2019;47:50–2.
Levy AD, Murakata LA, Rohrmann CA Jr. Gallbladder carcinoma: radiologic-pathologic correlation. Radiographics. 2001;21(2):295–314.
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Barış Tuzcu, Osman Sütcüoğlu, Elif Kolay Bayram, Özlem Erdem, and Ozan Yazıcı. The first draft of the manuscript was written by Barış Tuzcu, Osman Sütcüoğlu, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Tuzcu, B., Sütcüoğlu, O., Bayram, E.K. et al. Krukenberg Tumor Presentation of Recurrent Gallbladder Cancer After a Decade. J Gastrointest Canc 54, 264–267 (2023). https://doi.org/10.1007/s12029-021-00761-4
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DOI: https://doi.org/10.1007/s12029-021-00761-4