Abstract
Purpose
Removal of obstructive jaundice in metastatic pancreatic cancer is an important part of palliative therapy. However, it is not known whether invasive procedures reduce cancer-related mortality. In this study, the effect of palliative biliary drainage on survival outcomes in pancreatic cancer patients was evaluated.
Methods
Patients diagnosed with pancreatic cancer and undergoing biliary drainage in two different centers between 2010 and 2019 were evaluated retrospectively.
Results
Biliary drainage was applied to 73 patients, constituting 20.6% of 355 patients included in the study. The median progression-free survival (PFS) of patients with biliary stent was 5 months, while the median PFS of patients without stenting was 5.5 months and the median overall survival (OS) was 11.1 and 11.5 months, respectively (p: 0.424, p: 0.802).
Conclusions
A positive effect of palliative biliary drainage on median PFS and OS could not be demonstrated in our study group. In pancreatic cancer, predictive markers are needed to select patients who can derive a survival benefit from biliary drainage.
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APE, FE, and GG conceived and designed research. APE, FE, SY, and AÖ collected and processed data. AÖ and SY analyzed and interpreted data. APE and FE wrote the manuscript. GG supervised and made critical review. All authors read and approved the manuscript.
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Our study was conducted according to the criteria set by the Declaration of Helsinki, and Manisa Celal Bayar University Faculty of Medicine Ethics Committee approved the study (approval no: 22.03.2021, date: 142).
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Erdoğan, A.P., Ekinci, F., Yıldırım, S. et al. Palliative Biliary Drainage Has No Effect on Survival in Pancreatic Cancer: Medical Oncology Perspective. J Gastrointest Canc 53, 52–56 (2022). https://doi.org/10.1007/s12029-021-00754-3
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DOI: https://doi.org/10.1007/s12029-021-00754-3