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De Novo Malignancies After Liver Transplantation: Experience of a High-Volume Center

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Abstract

Purpose

Patient care, newer immunosuppressive medications, and advances in surgical technique, have resulted in significant prolongation of survival after liver transplantation in recent years. However, as life expectancy increased and the early mortality rates have decreased, different problems have evolved due to chronic immunosuppressive therapy. The aim of the present study is to evaluate patients who were transplanted and then developed de novo malignancies, in terms of the type of malignancies and the follow-up period.

Methods

The study was conducted on 2814 patients who received liver transplantation between 2008 and 2020 in Inonu University Liver Transplant Institute. In total, the data of 23 patients were evaluated retrospectively.

Results

Non-melanoma skin cancer was the most common de novo malignancy (21.7%), followed by gynecological cancers (17.3%). The interval between the time of transplantation until the development of de novo malignancy was 36 (6–75) months. The median follow-up period after the diagnoses of the de novo malignancies was 4.11 years. One, 3-, 5-year survival rates of patients after the diagnoses of de novo malignancies were 69.6%, 56.5%, and 41.9%; respectively.

Conclusion

Non-melanotic skin cancers were the most common de novo cancers in liver transplant recipients. A strict surveillance program is very important in the follow-up of liver transplant recipients.

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taken from S. Yilmaz archive)

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Abbreviations

LT :

Liver transplantation

ICD-10 :

International Classification of Disease 10

HCC :

Hepatocellular cancer

HBV :

Hepatitis B virus

PLTD :

Post-transplant lymphoproliferative disorders

PFIC :

Progressive familial intrahepatic cholestasis

PCR :

Polymerase chain reaction

CMV :

Cytomegalovirus

EBV :

Epstein-Barr virus

DNA :

Deoxyribonucleotide acid

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Liver Transplantation Institute, Inonu University School of Medicine, 44315, Malatya, Turkey

    Kutay Saglam

  2. Department of Surgery, Liver Transplantation Institute, Inonu University, 44315, Malatya, Turkey

    Tevfik Tolga Sahin, Volkan Ince, Sertac Usta & Sezai Yilmaz

  3. Department of Surgery, Liver Transplantation Institute, Inonu University, 44315, Malatya, Turkey

    Zeki Ogut

Authors
  1. Kutay Saglam
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  2. Tevfik Tolga Sahin
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  4. Volkan Ince
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  5. Sertac Usta
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Correspondence to Kutay Saglam.

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Saglam, K., Sahin, T.T., Ogut, Z. et al. De Novo Malignancies After Liver Transplantation: Experience of a High-Volume Center. J Gastrointest Canc 53, 1020–1027 (2022). https://doi.org/10.1007/s12029-021-00749-0

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  • DOI: https://doi.org/10.1007/s12029-021-00749-0

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