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Potential Non-invasive Biomarkers of Helicobacter pylori-Associated Gastric Cancer

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Abstract

Background

Gastric cancer (GC) remains the fifth most common incident cancer with the highest incidence in East Asian countries and the third leading cause of cancer death worldwide. The causal association between non-cardia GC and Helicobacter pylori (H. pylori) has been firmly documented by clinical and epidemiological studies. According to the guidelines for diagnosis and treatment of H. pylori infection, eradication therapy is strongly recommended. Early detection of GC is critical and can save lives through rapid technological advancement. At present, endoscopy remains the most efficient technique. However, it is invasive and costs highly.

Methods

An extensive bibliographic search was performed via PubMed/Medline, Web of Science, and EBSCO host databases to select studies conducted within the past 8 years. Forty-six relevant analyses were encompassed in this review.

Results

Several non-invasive candidate biomarkers associated with H. pylori, divided into virulence markers, transcriptome markers, genomic markers, and inflammatory markers, have been shown to be potential predictors of GC at an early stage.

Conclusion

The discovery of non-invasive biomarkers offers new perspectives for screening, early detection, and monitoring of individuals at risk.

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Change history

  • 23 January 2022

    "EL" of 3rd author's name should be captured as Family name. Full family name should be "EL KADMIRI"

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Authors and Affiliations

  1. Laboratory of Cell Biology and Molecular Genetics, Faculty of Science, Ibn Zohr University, Agadir, Morocco

    Fatima BOUBRIK & Ahmed BELMOUDEN

  2. Molecular Engineering, Valorization and Environment Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Hay El Mohammadi (Lastah), Taroudannt, BP: 271, 83000, Morocco

    Nadia EL KADMIRI

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BOUBRIK, F., BELMOUDEN, A. & EL KADMIRI, N. Potential Non-invasive Biomarkers of Helicobacter pylori-Associated Gastric Cancer. J Gastrointest Canc 53, 1113–1120 (2022). https://doi.org/10.1007/s12029-021-00734-7

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