Abstract
Purpose
This study aims to provide an overview of the literature on carcinoma arising from giant perianal condyloma acuminatum.
Methods
We present a new case of squamous cell carcinoma arising from giant perianal condyloma acuminatum. We also conducted a systematic search of the medical literature using PubMed, Medline, Google, and Google Scholar related to carcinoma arising from giant perianal condyloma acuminatum. The following search terms were used in various combinations: condyloma acuminatum, giant condyloma acuminatum, Buschke-Lowenstein tumor, squamous cell carcinoma, and verrucous carcinoma. The search included articles published before in the English language November 2020.
Results
A total of 55 article concerning 97 patients with carcinoma (squamous cell carcinoma, verrucous carcinoma, basaloid cell carcinoma, carcinoma insitu) arising from giant perianal condyloma acuminatum meeting the aforementioned criteria were included. The patients were aged from 24 to 82 years (median: 49.6, IQR: 21); 20 were female (median age: 52.5, IQR: 20.5), and 75 were male (median age: 53, IQR: 17.5). The gender data of the remaining two patients could not be obtained. The histopathological features of tumors arising from giant condyloma acuminatum are as follows: squamous cell carcinoma (n = 56), squamous cell carcinoma in situ (n = 16), verrucous carcinoma (n = 19) and basaloid cell carcinoma (n = 1), squamous cell carcinoma + verrucous carcinoma (n = 1), squamous cell carcinoma + squamous cell carcinoma in situ (n = 1), squamous cell carcinoma + basaloid cell carcinoma (n = 1) and malignant behavior (n = 2).
Conclusion
Giant condyloma acuminatum is a rare variant of anogenital warts. It is known that this tumor, which is mostly thought to be benign, has a high potential for local recurrence and transformation into invasive cancer. Therefore, it is vital that the tumor is resected with clean surgical margins, even if it looks benign, and that aggressive treatment options are not avoided when necessary.
Similar content being viewed by others
Availability of Data and Material
Data sharing is not applicable to this article as no new data were created.
Code Availability
Not applicable.
References
Luchtefeld MA. Perianal condylomata acuminata. Surg Clin North Am. 1994;74:1327–38. https://doi.org/10.1016/s0039-6109(16)46484-4.
Puy-Montbrun T, Denis J, Ganansia R, Mathoniere F, Lemarchand N, Arnous-Dubois N. Anorectal lesions in human immunodeficiency virus-infected patients. Int J Colorectal Dis. 1992;7:26–30. https://doi.org/10.1007/BF01647657.
Kibrité A, Zeitouni NC, Cloutier R. Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report. Can J Surg. 1997;40:143–5.
Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis. 2013;13:39. https://doi.org/10.1186/1471-2334-13-39.
Renzi A, Giordano P, Renzi G, Landolfi V, Del Genio A, Weiss EG. Buschke-Lowenstein tumor successful treatment by surgical excision alone: a case report. Surg Innov. 2006;13:69–72. https://doi.org/10.1177/155335060601300111.
Chaidemenos G, Kogia M, Souparis A, Kastoridou C, Karakatsanis G, Xenidis E, Mourellou O. Radical excision and mesh-skin grafting for giant anorectal condyloma acuminatum. Dermatol Surg. 2006;32:324–8. https://doi.org/10.1111/j.1524-4725.2006.32060.x.
Fanget F, Pasquer A, Djeudji F, Chabanon J, Barth X. Should the surgical management of Buschke-Lowenstein tumors be aggressive? About 10 Cases. Dig Surg. 2017;34:247–52. https://doi.org/10.1159/000452496.
Ahsaini M, Tahiri Y, Tazi MF, Elammari J, Mellas S, Khallouk A, El Fassi MJ, Farih MH, Elfatmi H, Amarti A, Stuurman-Wieringa RE. Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-Löwenstein tumor): a case report and review of the literature. J Med Case Rep. 2013;7:273. https://doi.org/10.1186/1752-1947-7-273.
Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum. 1994;37:950–7. https://doi.org/10.1007/BF02052606.
Nordsiek M, Ross C, Metro M. Successful surgical management of Giant Condyloma Acuminatum (Buschke Lowenstein Tumor) in the urethra of a female patient: a case report. Curr Urol. 2015;8:49–52. https://doi.org/10.1159/000365689.
Blomberg M, Friis S, Munk C, Bautz A, Kjaer SK. Genital warts and risk of cancer: a Danish study of nearly 50 000 patients with genital warts. J Infect Dis. 2012;205:1544–53. https://doi.org/10.1093/infdis/jis228.
Schlecht HP, Fugelso DK, Murphy RK, Wagner KT, Doweiko JP, Proper J, Dezube BJ, Panther LA. Frequency of occult high-grade squamous intraepithelial neoplasia and invasive cancer within anal condylomata in men who have sex with men. Clin Infect Dis. 2010;51:107–10. https://doi.org/10.1086/653426.
Park IU, Introcaso C, Dunne EF. Human papillomavirus and genital warts: a review of the evidence for the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. Clin Infect Dis. 2015;61:S849–55. https://doi.org/10.1093/cid/civ813.
Heck DV, Yee CL, Howley PM, Münger K. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc Natl Acad Sci U S A. 1992;89:4442–6. https://doi.org/10.1073/pnas.89.10.4442.
Orlando G, Fasolo MM, Beretta R, Merli S, Cargnel A. Combined surgery and cidofovir is an effective treatment for genital warts in HIV-infected patients. AIDS. 2002;16:447–450. https://doi.org/10.1097/00002030-200202150-00017.
Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J. Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour. Surgeon. 2006;4:378–83. https://doi.org/10.1016/s1479-666x(06)80114-9.
De Toma G, Cavallaro G, Bitonti A, Polistena A, Onesti MG, Scuderi N. Surgical management of perianal giant condyloma acuminatum (Buschke-Löwenstein tumor). Report of three cases. Eur Surg Res. 2006;38:418–22. https://doi.org/10.1159/000094979.
Murray ML, Meadows J, Doré CJ, Copas AJ, Haddow LJ, Lacey C, Jit M, Soldan K, Bennett K, Tetlow M, Nathan M, Gilson R. Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial). BMC Med Res Methodol. 2018;18:125. https://doi.org/10.1186/s12874-018-0581-z.
Shi H, Zhang X, Ma C, Yu N, Wang J, Xia L, Ge X, Liu M, Duan A. Clinical analysis of five methods used to treat condylomata acuminata. Dermatology. 2013;227:338–345. https://doi.org/10.1159/000355351.
Manzione Tda S, Nadal SR, Calore EE, Nadal LR, Manzione CR. Local control of human papillomavirus infection after anal condylomata acuminata eradication. Rev Col Bras Cir. 2014;41:87–91. https://doi.org/10.1590/s0100-69912014000200003.
Protasov AD, Lipatov IS, Kostinov MP, Tezikov YV, Shmitko AD, Pakhomov DV, Blagovidov DA, Zhestkov AV, Ryzhov AA, Vekhova EV. Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up). Urologiia. 2016;5:47–51.
Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis. 2012;54:891–8. https://doi.org/10.1093/cid/cir1036.
Garbuglia AR, Lapa D, Sias C, Capobianchi MR, Del Porto P. The use of both therapeutic and prophylactic vaccines in the therapy of papillomavirus disease. Front Immunol. 2020;11:188. https://doi.org/10.3389/fimmu.2020.00188.
Author information
Authors and Affiliations
Contributions
Ates M, Akbulut S, Karabulut E, and Sarici KB conceived and designed research. Akbulut S, Ates M, Tuncer A, and Sahin E conducted the research. Karabulut E, Tuncer A, Sahin E, and Akbulut S contributed to data extraction. All authors wrote the manuscript. All authors read and approved the manuscript.
Corresponding author
Ethics declarations
Ethics Approval
Not applicable.
Consent to Participate
Not applicable.
Competing Interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Ates, M., Akbulut, S., Tuncer, A. et al. Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review. J Gastrointest Canc 53, 1083–1092 (2022). https://doi.org/10.1007/s12029-021-00713-y
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12029-021-00713-y