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Association of Interleukin-10 Polymorphisms with Susceptibility to Colorectal Cancer and Gastric Cancer: an Updated Meta-analysis Based on 106 Studies

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Abstract

Background

The purpose of this study was to explore the association of IL-10 polymorphisms with susceptibility to colorectal cancer (CRC) and gastric cancer (GC).

Methods

PubMed, Scopus, Embase, SciELO, medRxiv, China Biology Medicine Disc, DeepDyve, CNKI, and Web of Science were used to identify all relevant articles published up to 20th June 2021, without any restrictions on ethnicity. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were used to determine the strength of the associations.

Results

A total of 106 case–control studies were included. For CRC, 15 studies with 2772 cases and 3719 controls on -1082A/G, 11 studies with 3259 cases and 4992 controls on -592C/A, and 3 studies with 477 cases and 544 controls on -819 T/C were selected. For GC, 31 studies with 6229 cases and 8666 controls on -1082A/G, 27 studies with 5457 cases and 8381 controls on -592C/A, and 19 studies with 3556 cases and 6218 controls on -819 T/C were included. Pooled data showed a significant association between IL-10-819 T/C polymorphism and CRC susceptibility in overall population, but not for IL-10-1082A/G and -592C/A polymorphisms. However, IL-10-592C/A polymorphism was associated with CRC risk in Asians. A significant association of IL-10-1082A/G polymorphism with the GC risk was found. In the ethnicity subgroup analysis, a significant association was found between IL-10-1082A/G polymorphism and GC risk among Asians. The IL-10-819 T/C was not associated with GC risk in overall population and by ethnicity.

Conclusions

Our pooled data show a significant association of IL-10-819 T/C and IL-10-1082A/G polymorphisms with CRC and GC in overall population, respectively. However, other factors may influence these associations, and large-scale studies with adequate methodological quality are necessary to confirm the impact on CRC and GC risk.

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References

  1. Lyons K, Le LC, Pham YTH, Borron C, Park JY, Tran CTD, et al. Gastric cancer: Epidemiology, biology, and prevention: a mini review. Eur J Cancer Prev. 2019;28:397–412. https://doi.org/10.1097/CEJ.0000000000000480.

    Article  PubMed  Google Scholar 

  2. Antikchi MH, Neamatzadeh H, Ghelmani Y, Jafari-Nedooshan J, Dastgheib SA, Kargar S, et al. The risk and prevalence of COVID-19 infection in colorectal cancer patients: a systematic review and meta-analysis. J Gastrointest Cancer. 2021;52:73–9. https://doi.org/10.1007/s12029-020-00528-3.

    Article  CAS  PubMed  Google Scholar 

  3. Mannucci A, Zuppardo RA, Rosati R, Di Leo M, Perea J, Cavestro GM. Colorectal cancer screening from 45 years of age: thesis, antithesis and synthesis. World J Gastroenterol. 2019;25:2565–80. https://doi.org/10.3748/wjg.v25.i21.2565.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Takeshima H, Ushijima T. Accumulation of genetic and epigenetic alterations in normal cells and cancer risk. Npj Precision Oncology. 2019;3:1–8. https://doi.org/10.1038/s41698-019-0079-0.

    Article  Google Scholar 

  5. Fatehi Z, Amirmahani F, Tavassoli M. Association study of TAAAA polymorphism in the first intron of p53 gene with risk of colorectal cancer in Iranian population. Egypt J Med Hum Genet. 2019;20:2–5. https://doi.org/10.1186/s43042-019-0024-3.

    Article  Google Scholar 

  6. Parsafar S, Hematti S, Ghorbani F, Safari F, Tavassoli M. Polymorphic GT dinucleotide repeat in the PIK3CA gene and risk of colorectal cancer. Cancer Biomark. 2015;15:397–403. https://doi.org/10.3233/CBM-150487.

    Article  CAS  PubMed  Google Scholar 

  7. Ferdosian F, Dastgheib SA, Morovati-Sharifabad M, Lookzadeh MH, Noorishadkam M, Mirjalili SR, et al. Cumulative evidence for association between il-10 polymorphisms and kawasaki disease susceptibility: a systematic review and meta-analysis. Fetal Pediatr Pathol. 2019:1–13. https://doi.org/10.1080/15513815.2019.1686789. Online ahead of print.

  8. Moghmi M, Arjmandi A, Aghili K, Jafari M, Zare-Shehneh M, Rastegar S, et al. Association of interleukin-10–592a>c and-819t>c polymorphisms with gastric cancer risk: a systematic review and meta-analysis of 44 case-control studies. Arq Bras Cir Dig. 2019;32. https://doi.org/10.1590/0102-672020180001e1415.

  9. Yu Z, Liu Q, Huang C, Wu M, Li G. The interleukin 10 −819C/T polymorphism and cancer risk: a HuGE review and meta-analysis of 73 studies including 15,942 cases and 22,336 controls. OMICS: A Journal of Integrative Biology. 2013;17:200–14. https://doi.org/10.1089/omi.2012.0089.

  10. Wang X, Yang F, Xu G, Zhong S. The roles of IL-6, IL-8 and IL-10 gene polymorphisms in gastric cancer: a meta-analysis. Cytokine. 2018;111:230–6. https://doi.org/10.1016/j.cyto.2018.08.024.

    Article  CAS  PubMed  Google Scholar 

  11. Gu T, De Jesus M, Gallagher HC, Burris TP, Egilmez NK. Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4+ T-cells and induction of antitumor CD8+ T-cell activity. OncoImmunology. 2017;6:e1319027. https://doi.org/10.1080/2162402X.2017.1319027.

  12. Bahrami R, Dastgheib SA, Niktabar SM, Amooee A, Lookzadeh MH, Mirjalili SR, et al. Association of BMP4 rs17563 polymorphism with nonsyndromic cleft lip with or without cleft palate risk: literature review and comprehensive meta-analysis. Fetal Pediatr Pathol. 2020:1–15. https://doi.org/10.1080/15513815.2019.1707916. Online ahead of print.

  13. Macarthur M, Sharp L, Hold GL, Little J, El-Omar EM. The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the Northeast of Scotland. Cancer Epidemiol Biomark Prev. 2005;14:1613–8. https://doi.org/10.1158/1055-9965.EPI-04-0878.

    Article  CAS  Google Scholar 

  14. Crivello A, Giacalone A, Vaglica M, Scola L, Forte GI, Macaluso MC, et al. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann N Y Acad Sci. 2006;1089:98–103. https://doi.org/10.1196/annals.1386.002.

    Article  CAS  PubMed  Google Scholar 

  15. Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N. Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomark Prev. 2006;15:1126–31. https://doi.org/10.1158/1055-9965.EPI-06-0042.

    Article  CAS  Google Scholar 

  16. Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, et al. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Hum Immunol. 2007;68:698–704. https://doi.org/10.1016/j.humimm.2007.05.002.

    Article  CAS  PubMed  Google Scholar 

  17. Talseth BA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott RJ. Lack of association between genetic polymorphisms in cytokine genes and disease expression in patients with hereditary non-polyposis colorectal cancer. Scand J Gastroenterol. 2007;42:628–32. https://doi.org/10.1080/00365520601106699.

    Article  CAS  PubMed  Google Scholar 

  18. Wilkening S, Tavelin B, Canzian F, Enquist K, Palmqvist R, Altieri A, et al. Interleukin promoter polymorphisms and prognosis in colorectal cancer. Carcinogenesis. 2008;29:1202–6. https://doi.org/10.1093/carcin/bgn101.

    Article  CAS  PubMed  Google Scholar 

  19. Cacev T, Radosević S, Krizanac S, Kapitanović S. Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinogenesis. 2008;29:1572–80. https://doi.org/10.1093/carcin/bgn164.

    Article  CAS  PubMed  Google Scholar 

  20. Tsilidis KK, Helzlsouer KJ, Smith MW, Grinberg V, Hoffman-Bolton J, Clipp SL, et al. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes & Control : CCC. 2009;20:1739–51. https://doi.org/10.1007/s10552-009-9427-7.

    Article  PubMed  Google Scholar 

  21. Miteva LD, Stanilov NS, Deliysky TS, Stanilova SA. Significance of -1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression. Tumour Biology : The Journal of the International Society for Oncodevelopmental Biology and Medicine. 2014;35:12655–64. https://doi.org/10.1007/s13277-014-2589-2.

    Article  CAS  Google Scholar 

  22. Burada F, Dumitrescu T, Nicoli R, Ciurea ME, Rogoveanu I, Ioana M. Cytokine promoter polymorphisms and risk of colorectal cancer. Clin Lab. 2013;59:773–9.

    Article  CAS  PubMed  Google Scholar 

  23. Basavaraju U, Shebl FM, Palmer AJ, Berry S, Hold GL, El-Omar EM, et al. Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland. Eur J Cancer Prev. 2015;24:296–304. https://doi.org/10.1097/CEJ.0000000000000087.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Li HX, Li YY, Song ZJ, He SX, Guo QY. Association between IL-8–251A/T and il-10–1082A/G genetic polymorphisms and susceptibility to colorectal cancer: a case-control study in a population in Shaanxi. World Chin J Dig. 2015;23:1184–90

  25. Cai J, Zhang Z. An analysis of IL-10/IL-10R genetic factors related to risk of colon cancer and inflammatory bowel disease in a Han Chinese population. Clin Lab. 2016;62:1147–54.

    Article  CAS  PubMed  Google Scholar 

  26. Gulubova M, Aleksandrova E, Vlaykova T. Promoter polymorphisms in TGFB1 and IL10 genes influence tumor dendritic cells infiltration, development and prognosis of colorectal cancer. J Gene Med. 2018:e3005. https://doi.org/10.1002/jgm.3005.

  27. Althubyani SA, Alkhuriji AF, Al Omar SY, El-Khadragy MF. A preliminary study of cytokine gene polymorphism effects on saudi patients with colorectal cancer. Saudi Med J. 2020;41:1292–300. https://doi.org/10.15537/smj.2020.12.25543.

  28. Vogel U, Christensen J, Dybdahl M, Friis S, Hansen RD, Wallin H, et al. Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res. 2007;624:88–100. https://doi.org/10.1016/j.mrfmmm.2007.04.006.

    Article  CAS  PubMed  Google Scholar 

  29. Andersen V, Egeberg R, Tjønneland A, Vogel U. Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study. BMC Cancer. 2012;12:183. https://doi.org/10.1186/1471-2407-12-183.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Yu Y, Zheng S, Zhang S, Jin W, Liu H, Jin M, et al. Polymorphisms of inflammation-related genes and colorectal cancer risk: a population-based case-control study in China. Int J Immunogenet. 2014;41:289–97. https://doi.org/10.1111/iji.12119.

    Article  CAS  PubMed  Google Scholar 

  31. Banday MZ, Balkhi HM, Sameer AS, Chowdri NA, Haq E. Strong association of interleukin-6 −174G/C promoter single nucleotide polymorphism with a decreased risk of colorectal cancer in ethnic Kashmiri population: a case control study. Tumor Biology. 2017;39:101042831769594. https://doi.org/10.1177/1010428317695940.

    Article  CAS  Google Scholar 

  32. Mirjalili SA, Moghimi M, Aghili K, Jafari M, Abolbaghaei SM, Neamatzadeh H, et al. Association of promoter region polymorphisms of interleukin-10 gene with susceptibility to colorectal cancer: a systematic review and meta-analysis. Arq Gastroenterol. 2018;55:306–13. https://doi.org/10.1590/S0004-2803.201800000-66.

    Article  PubMed  Google Scholar 

  33. Wang P, An J, Zhu Y, Wan X, Zhang H, Xi S, et al. Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis. Oncotarget. 2017;8:62382–99. https://doi.org/10.18632/oncotarget.18220.

  34. Shi YH, Zhao DM, Wang YF, Li X, Ji MR, Jiang DN, et al. The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: a meta-analysis. Sci Rep. 2016;6:30809. https://doi.org/10.1038/srep30809.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Kim J, Kim Y, Lee K-A. Ethnic differences in gastric cancer genetic susceptibility: allele flips of interleukin gene. World J Gastroenterol. 2014;20:4558–65. https://doi.org/10.3748/wjg.v20.i16.4558.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Tang J, Pan R, Xu L, Ma Q, Ying X, Zhao J, et al. IL10 hypomethylation is associated with the risk of gastric cancer. Oncol Lett. 2021;21:1–1. https://doi.org/10.3892/ol.2021.12502.

    Article  CAS  Google Scholar 

  37. Chen L, Shi Y, Zhu X, Guo W, Zhang M, Che Y, et al. IL-10 secreted by cancer-associated macrophages regulates proliferation and invasion in gastric cancer cells via c-Met/STAT3 signaling. Oncol Rep. 2019;42:595–604. https://doi.org/10.3892/or.2019.7206.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Kulmambetova G, Shtefanov I, Aitkulova A, Imanbekova M, Iskakova A, Makishev A, et al. Association of polymorphisms in TP53 and the promoter region of il10 with gastric cancer in a Kazakh population. Bosn J Basic Med Sci. 2020;20:539–46. https://doi.org/10.17305/bjbms.2020.4761.

  39. Martínez-Campos C, Torres-Poveda K, Camorlinga-Ponce M, Flores-Luna L, Maldonado-Bernal C, Madrid-Marina V, et al. Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population. BMC Cancer. 2019;19. https://doi.org/10.1186/s12885-019-5627-z.

  40. Cárdenas DM, Sánchez AC, Rosas DA, Rivero E, Paparoni MD, Cruz MA, et al. Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer. BMC Gastroenterol. 2018;18:v. https://doi.org/10.1186/s12876-018-0913-9.

    Article  CAS  Google Scholar 

  41. Song X, Wang D, Ben B, Xiao C, Bai L, Xiao H, et al. Association between interleukin gene polymorphisms and susceptibility to gastric cancer in the Qinghai population. J Int Med Res. 2021;49:1–14. https://doi.org/10.1177/03000605211004755.

    Article  CAS  Google Scholar 

  42. Namazi A, Forat-Yazdi M, Jafari M, Farahnak S, Nasiri R, Foroughi E, et al. Association of interleukin-10 -1082 A/G (rs1800896) polymorphism with susceptibility to gastric cancer: meta-analysis of 6,101 cases and 8,557 controls. Arq Gastroenterol. 2018;55:33–40. https://doi.org/10.1590/s0004-2803.201800000-18.

  43. Yan LR, Lv Z, Jing JJ, Yuan Y, Xu Q. Single nucleotide polymorphisms of whole genes and atrophic gastritis susceptibility: a systematic review and meta-analysis. Gene. 2021;782. https://doi.org/10.1016/j.gene.2021.145543.

  44. Wu M-S, Huang S-P, Chang Y-T, Shun C-T, Chang M-C, Lin M-T, et al. Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. J Infect Dis [Internet]. 2002 [cited 2021 Sep 1];185:106–9. Available from: https://pubmed.ncbi.nlm.nih.gov/11756988/.

  45. Wu M-S, Wu C-Y, Chen C-J, Lin M-T, Shun C-T, Lin J-T. Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese. Int J Cancer [Internet]. 2003 [cited 2018 Jul 1];104:617–23. Available from: http://doi.wiley.com/10.1002/ijc.10987.

  46. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology [Internet]. 2003;124:1193–201. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12730860.

  47. Savage SA, Abnet CC, Haque K, Mark SD, Qiao Y-L, Dong Z-W, et al. Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Internet]. 2004 [cited 2018 Apr 4];13:1547–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15342460.

  48. Lee JY, Kim HY, Kim KH, Kim SM, Jang MK, Park JY, et al. Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea. Cancer Lett [Internet]. 2005 [cited 2018 Apr 4];225:207–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15978325.

  49. Lu W, Pan K, Zhang L, Lin D, Miao X, You W. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. Carcinogenesis [Internet]. 2005 [cited 2019 Sep 4];26:631–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15579481.

  50. Guo W. Interleukin-10 -1082 promoter polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high-incidence region of north China. World J Gastroenterol [Internet]. 2005 [cited 2018 Jul 1];11:858. Available from: http://www.wjgnet.com/1007-9327/full/v11/i6/858.htm.

  51. Zambon C-F, Basso D, Navaglia F, Belluco C, Falda A, Fogar P, et al. Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. Cytokine [Internet]. 2005 [cited 2018 Apr 4];29:141–52. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1043466604003126.

  52. Alpízar-Alpízar W, Pérez-Pérez GI, Une C, Cuenca P, Sierra R. Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica. Clin Exp Med [Internet]. 2005 [cited 2018 Apr 4];5:169–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16362796.

  53. Morgan DR, Dominguez RL, Keku TO, Heidt PE, Martin CF, Galanko JA, et al. Gastric Cancer and the High Combination Prevalence of Host Cytokine Genotypes and Helicobacter pylori in Honduras. Clin Gastroenterol Hepatol [Internet]. 2006 [cited 2018 Jul 1];4:1103–11. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356506004940.

  54. Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY, et al. Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland). Cancer Causes Control [Internet]. 2006 [cited 2018 Jul 1];17:117–25. Available from: http://link.springer.com/10.1007/s10552-005-0439-7.

  55. Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, et al. Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol. [Internet]. 2007 [cited 2018 Jul 1];22:1443–9. Available from: http://doi.wiley.com/10.1111/j.1440-1746.2006.04613.x.

  56. García-González MA, Lanas A, Quintero E, Nicolás D, Parra-Blanco A, Strunk M, et al. Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-Inflammatory Cytokine Gene Polymorphisms in Whites: A Nationwide Multicenter Study in Spain. Am J Gastroenterol [Internet]. 2007 [cited 2018 Apr 4];102:1878–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17640324.

  57. Bai X-L, Sun L-P, Jin Liu WC, Zhang Y, Yuan Y. Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study. Ai Zheng [Internet]. 2008 [cited 2021 Sep 1];27:35–40. Available from: https://pubmed.ncbi.nlm.nih.gov/18184461/.

  58. Forte GI, Calà C, Scola L, Crivello A, Gullo A, Marasà L, et al. Role of Environmental and Genetic Factor Interaction in Age-Related Disease Development: The Gastric Cancer Paradigm. Rejuvenation Res [Internet]. 2008 [cited 2018 Jul 1];11:509–12. Available from: http://www.liebertonline.com/doi/abs/10.1089/rej.2008.0678.

  59. Kang JM, Kim N, Lee DH, Park JH, Lee MK, Kim JS, et al. The Effects of Genetic Polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced Gastroduodenal Diseases in Korea. J Clin Gastroenterol [Internet]. 2009 [cited 2018 Apr 4];43:420–8. Available from: https://insights.ovid.com/crossref?an=00004836-200905000-00007.

  60. Ko K-P, Park SK, Cho LY, Gwack J, Yang JJ, Shin A, et al. Soybean Product Intake Modifies the Association between Interleukin-10 Genetic Polymorphisms and Gastric Cancer Risk. J Nutr [Internet]. 2009 [cited 2018 Jul 1];139:1008–12. Available from: https://academic.oup.com/jn/article/139/5/1008/4670335.

  61. Xiao H, Jiang Y, Li R, Xia B. Association of IL-10 gene polymorphisms with gastroduodenal diseases in Hubei Han population. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Internet]. 2009 [cited 2018 Apr 4];26:423–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20017308.

  62. Zhou Y, Hu W, Zhuang W, Wu X. Interleukin-10 -1082 promoter polymorphism and gastric cancer risk in a Chinese Han population. Molecular and cellular biochemistry [Internet]. Mol Cell Biochem. 2011 [cited 2021 Sep 1];347:89–93. Available from: https://pubmed.ncbi.nlm.nih.gov/20953818/.

  63. Shin CM, Kim N, Lee HS, Lee DH, Kim JS, Jung HC, et al. Intrafamilial aggregation of gastric cancer. Eur J Gastroenterol Hepatol [Internet]. 2011 [cited 2018 Jul 1];23:411–7. Available from: https://insights.ovid.com/crossref?an=00042737-201105000-00007.

  64. Liu J, Song B, Wang J-L, Li Z-J, Li W-H, Wang Z-H. Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer. World J Gastroenterol [Internet]. 2011 [cited 2018 Apr 4];17:1362. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21455338.

  65. He B, Pan Y, Xu Y, Nie Z, Chen L, Gu L, et al. Increased Risk for Gastric Cancer in Carriers of the Lymphotoxin-α+252G Variant Infected by Helicobacter pylori. Genet Test Mol Biomarkers [Internet]. 2012 [cited 2018 Apr 4];16:9–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21793721.

  66. Zeng X, Li Y, Liu T, Zhang J. Diverse H. pylori strains, IL-10 promoter polymorphisms with high morbidity of gastric cancer in Hexi area of Gansu Province, China. Mol Cell Biochem [Internet]. 2012 [cited 2018 Jul 1];362:241–8. Available from: http://link.springer.com/10.1007/s11010-011-1149-y.

  67. Kim J, Cho YA, Choi IJ, Lee Y-S, Kim S-Y, Shin A, et al. Effects of Interleukin-10 Polymorphisms, Helicobacter pylori Infection, and Smoking on the Risk of Noncardia Gastric Cancer. In: Katoh M, editor. PLoS One. [Internet]. 2012 [cited 2018 Jul 1]. vol. 7, p. e29643. Available from: http://dx.plos.org/10.1371/journal.pone.0029643.

  68. Chand-Bhayal A, Krishnaveni D, Pandu-Ranga-Rao K, Prabhakar B, Vidyasagar A, Murali-Krishna B, et al. Association of Interleukin-10 Promoter Polymorphism (-1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India. Iran J Cancer Prev [Internet]. Kowsar Medical Institute; 2012 [cited 2021 Sep 1];5:117. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294533/.

  69. Pan X-F, Yang S-J, Loh M, Xie Y, Wen Y-Y, Tian Z, et al. Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses. Asian Pac J Cancer Prev [Internet]. 2013 [cited 2018 Jul 1];14:2577–82. Available from: http://koreascience.or.kr/journal/view.jsp?kj=POCPA9&py=2013&vnc=v14n4&sp=2577.

  70. Kuo W-H, Huang C-Y, Fu C-K, Hsieh Y-H, Liao C-H, Hsu C-M, et al. Effects of interleukin-10 polymorphisms and smoking on the risk of gastric cancer in Taiwan. In vivo (Athens, Greece) [Internet]. 2014 [cited 2018 Apr 5];28:967–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25189915.

  71. Gonzalez-Hormazabal P, Musleh M, Bustamante M, Stambuk J, Escandar S, Valladares H, et al. Role of cytokine gene polymorphisms in gastric cancer risk in Chile. Anticancer Res [Internet]. 2014 [cited 2018 Apr 4];34:3523–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24982364.

  72. Kumar S, Kumari N, Mittal RD, Mohindra S, Ghoshal UC. Association between pro-(IL-8) and anti-inflammatory (IL-10) cytokine variants and their serum levels and H. pylori-related gastric carcinogenesis in northern India. Meta Gene. Elsevier B.V.; 2015;6:9–16.

  73. Sicinschi LA, Lopez-Carrillo L, Camargo MC, Correa P, Sierra RA, Henry RR, et al. Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes. Int J Cancer [Internet]. 2006 [cited 2018 Apr 4];118:649–57. Available from: http://doi.wiley.com/10.1002/ijc.21364.

  74. Crusius JBA, Canzian F, Capella G, Pena AS, Pera G, Sala N, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol [Internet]. 2008 [cited 2018 Dec 13];19:1894–902. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18628242.

  75. Deng W, He L, Peng X. [The relationship among IL-10 gene polymorphisms H elicobacter pylori and noncardia gastric cancer development in Fujian province]. [Article in Chinese]. Wei Chang Bing Xue He Gan Bing Xue Za Zhi. 2008;17:212–4.

  76. Con SA, Takeuchi H, Con-Chin GR, Con-Chin VG, Yasuda N, Con-Wong R. Role of bacterial and genetic factors in gastric cancer in Costa Rica. World J Gastroenterol [Internet]. Baishideng Publishing Group Inc; 2009 [cited 2018 Apr 4];15:211–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19132772.

  77. Oh SS, Chang S-C, Cai L, Cordon-Cardo C, Ding B-G, Greenland S, et al. Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers. Int J Cancer [Internet]. 2010 [cited 2018 Apr 4];127:2169–82. Available from: http://doi.wiley.com/10.1002/ijc.25214.

  78. Yin J, Wang X, Wei J, Wang L, Shi Y, Zheng L, et al. Interleukin 12B rs3212227 T > G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. Dis Esophagus [Internet]. 2015 [cited 2018 Apr 4];28:291–8. Available from: https://academic.oup.com/dote/article-lookup/doi/10.1111/dote.12189.

  79. de Oliveira JG, Rossi AFT, Nizato DM, Cadamuro ACT, Jorge YC, Valsechi MC, et al. Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. Tumor Biol. Springer Netherlands; 2015;36:9159–70.

  80. Ma B, Zhang T, Wan Y, Zhan F. [A case-control study of interleukin-10 gene -592A/C polymorphism and the risk of gastric cancer]. [Article in Chinese]. [Internet]. 2016 [cited 2018 Apr 5]. p. 580–2. Available from: http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=nxyxzz201607002.

  81. Su SP, Yang ZB, Tian YL, Xiang Y, Wu M, Ma X. Relationship between polymorphisms of IL-1β-31, IL-10-819 and TNF-α-1031 genes and susceptibilities to H. pylori infection-associated gastric ulcer and cancer]. [Article in Chinese]. Chin J Biol [Internet]. Geological Survey of Canada; 2010 [cited 2018 Apr 5];23:517–20. Available from: https://www.cabdirect.org/cabdirect/abstract/20103216985.

  82. Yuan LJ, Jin TB, Yin JK, Du XL, Wang Q, Dong R, et al. Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population. Cancer Epidemiol [Internet]. 2012 [cited 2021 Sep 1];36:e366-72. Available from: https://pubmed.ncbi.nlm.nih.gov/22796266/.

  83. Li L, Tang XY, Ye LM, Yang Q, Li Y. Investigation on the association between IL-10 C819T gene polymorphisms and susceptibility to gastric cancer. Genet Mol Res [Internet]. 2016 [cited 2018 Apr 4];15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28002581.

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Acknowledgements

The authors thank the editors and the anonymous reviewers for insightful suggestions on this study.

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Authors and Affiliations

  1. Department of General Surgery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

    Mohammad Zare & Seyed Mostafa Tabatabaie

  2. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Alireza Dastgheib

  3. Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran

    Fatemeh Asadian

  4. Shiraz University of Medical Sciences, Shiraz, Iran

    Sepideh Setayesh

  5. Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hamid Mirjalili

  6. Department of Emergency Medicine, Iran, University of Medical Sciences, Tehran, Iran

    Seyed Hossein Shaker

  7. Department of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Jalal Sadeghizadeh-Yazdi

  8. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh

  9. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh

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  1. Mohammad Zare
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  2. Seyed Alireza Dastgheib
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Contributions

Conceptualization: Mohammad Zare, Seyed Alireza Dastgheib, Seyed Mostafa Tabatabaie. Data curation: Saeed Kargar, Hossein Neamatzadeh. Formal analysis: Seyed Alireza Dastgheib, Hamid Mirjalili. Investigation: Fatemeh Asadian, Sepideh Setayesh. Methodology: Seyed Alireza Dastgheib, Hossein Neamatzadeh. Project administration: Seyed Mostafa Tabatabaie. Resources: Mohammad Zare, Seyed Mostafa Tabatabaie. Software: Seyed Alireza Dastgheib, Hossein Neamatzadeh. Supervision: Seyed Alireza Dastgheib, Mohammad Zare, Seyed Mostafa Tabatabaie. Validation: Hossein Neamatzadeh, Fatemeh Asadian. Visualization: Hamid Mirjalili, Sepideh Setayesh. Writing-original draft: Seyed Hossein Shaker Hossein Neamatzadeh, Sepideh Setayesh. Writing-review and editing: Hamid Mirjalili, Hossein Neamatzadeh, Seyed Hossein Shaker.

Corresponding author

Correspondence to Seyed Mostafa Tabatabaie.

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Zare, M., Dastgheib, S., Tabatabaie, S. et al. Association of Interleukin-10 Polymorphisms with Susceptibility to Colorectal Cancer and Gastric Cancer: an Updated Meta-analysis Based on 106 Studies. J Gastrointest Canc 53, 1066–1082 (2022). https://doi.org/10.1007/s12029-021-00685-z

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