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The Clinico-histopathological Spectrum of Tumors and Tumor-Like Lesions in Adult Intussusception

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Abstract

Background

Intussusception is an uncommon cause of intestinal obstruction in adults. The etiology of this disease differs from the children. Thus, its management depends on the possible etiology and is different from pediatric cases.

Aims

We aimed to study the clinico-histopathological spectrum of the tumors and tumor-like lesions in the intussusception in adults.

Material and Methods

A retrospective review of the adult (> 18 years) intussusception cases was performed. The clinical data and follow-up were obtained. The histopathology was reviewed along with the special stains and immunohistochemistry for ascertaining a histopathological diagnosis.

Results

Fifteen cases of adult intussusception were identified from 107 resected specimens of adult intestinal obstruction. The mean age was 44.5 years with a male/female ratio of 1.1:1. A definitive pathology could be ascertained in 80% of the cases (n = 12/15). Eight cases had benign non-neoplastic etiology (53.3%) (33.3% tumor-like lesions) while seven cases (46.7%) had neoplastic etiology (20% benign neoplastic; 26.7% malignant neoplastic). All cases of colonic or enterocolic intussusceptions were associated with neoplasia whereas 90% of the enteric intussusceptions occurred due to benign non-neoplastic causes. 

Conclusions

Non-neoplastic causes are predominant in the enteric intussusceptions while neoplastic causes are more commonly associated with colonic or enterocolic intussusceptions. The post-operative histopathological examination concludes on the adequacy of the index surgery or the provision of further management if required.

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Acknowledgements

The authors thank Drs. Pritinanda Mishra and Mukund N. Sable, Additional and Associate Professors, Dept of Pathology and Lab medicine, AIIMS, Bhubaneswar for diagnostic inputs. The authors also thank Mr Samiur Raheman, Technician-in-charge in the Dept of Pathology and Lab Medicine, AIIMS, Bhubaneswar for his assistance.

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Authors and Affiliations

  1. Dept of Pathology and Lab Medicine, AIIMS, Bhubaneswar, PIN-751019, India

    Pavithra Ayyanar, Gayatri Behera, Suvendu Purkait, Susama Patra & Suvradeep Mitra

  2. Dept of General Surgery, AIIMS, Bhubaneswar, PIN-751019, India

    Tushar Subhadarshan Mishra

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  1. Pavithra Ayyanar
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  2. Gayatri Behera
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  4. Suvendu Purkait
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Contributions

PA collected and analyzed the data and prepared the manuscript. GB aided in the collection and analysis of the data. TSM provided the clinical data and critically reviewed the manuscript. SPu and SPa aided in the review of the cases and critically reviewed the manuscript. SM conceptualized the idea, reviewed the cases, analyzed the data, and reviewed the manuscript.

Corresponding author

Correspondence to Suvradeep Mitra.

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Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Institutional Ethical Committee (T/IM-MF/Patho/19/68).

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Ayyanar, P., Behera, G., Mishra, T.S. et al. The Clinico-histopathological Spectrum of Tumors and Tumor-Like Lesions in Adult Intussusception. J Gastrointest Canc 53, 511–519 (2022). https://doi.org/10.1007/s12029-021-00647-5

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  • DOI: https://doi.org/10.1007/s12029-021-00647-5

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