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Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis

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References

  1. Gao HQ, Yang YM, Zhuang Y, Liu P. Locally advanced undifferentiated carcinoma with osteoclast-like giant cells of the pancreas. World J Gastroenterol. 2015;21(2):694–8. https://doi.org/10.3748/wjg.v21.i2.694.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Chiarelli M, Guttadauro A, Gerosa M, Marando A, Gabrielli F, de Simone M, et al. An indeterminate mucin-producing cystic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells: a case report of a rare association of pancreatic tumors. BMC Gastroenterol. 2015;15:161. https://doi.org/10.1186/s12876-015-0391-2.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Rosai J. Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin. Cancer. 1968;22:333–44.

    Article  CAS  Google Scholar 

  4. Riley DS, Barber MS, Kienle GS, Aronson JK, von Schoen-Angerer T, Tugwell P, et al. CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. 2017;89:218–35. https://doi.org/10.1016/j.jclinepi.2017.04.026.

    Article  PubMed  Google Scholar 

  5. Moore JC, Bentz JS, Hilden K, Adler DG. Osteoclastic and pleomorphic giant cell tumors of the pancreas: a review of clinical, endoscopic, and pathologic features. World J Gastrointest Endosc. 2010;2(1):15–9.

    Article  Google Scholar 

  6. Njoumi N, Elalami FH, Attolou G, Saoud O, Elabsi M, Echarrab M, et al. Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: a case report. J Gastrointest Canc. 2014;45:96–8. https://doi.org/10.1007/s12029-013-9572-9.

    Article  Google Scholar 

  7. Bauditz J, Rudolph B, Wermke W. Osteoclast-like giant cell tumors of the pancreas and liver. World J Gastroenterol. 2006;12(48):7878–83. https://doi.org/10.3748/wjg.v12.i48.7878.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, et al. Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: an analysis of 15 cases. Cancer Cytopathol. 2017;125(7):563–75. https://doi.org/10.1002/cncy.21859.

    Article  CAS  PubMed  Google Scholar 

  9. Kobayashi S, Nakano H, Ooike N, Oohashi M, Koizumi S, Otsubo T. Long-term survivor of a resected undifferentiated pancreatic carcinoma with osteoclast-like giant cells who underwent a second curative resection: a case report and review of the literature. Oncol Lett. 2014;8(4):1499–504. https://doi.org/10.3892/ol.2014.2325.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Jo S. Huge undifferentiated carcinoma of the pancreas with osteoclast-like giant cells. World J Gastroenterol. 2014;20(10):2725–30. https://doi.org/10.3748/wjg.v20.i10.2725.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma. J Pathol. 2017;243(2):148–54. https://doi.org/10.1002/path.4941.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R. Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature. Virchows Arch. 2020;477:687–96. https://doi.org/10.1007/s00428-020-02830-8.

    Article  CAS  PubMed  Google Scholar 

  13. Speisky D, Villarroel M, Vigovich F, Iotti A, García TA, Bella Quero L, et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas diagnosed by endoscopic ultrasound guided biopsy. ECancer Med Sci. 2020;14:1072. https://doi.org/10.3332/ecancer.2020.1072.

    Article  Google Scholar 

  14. Xu M, Chen W, Wang D, Nie M. Clinical characteristics and prognosis of osteoclast-like giant cell tumors of the pancreas compared with pancreatic adenocarcinomas: a population-based study. Med Sci Monit. 2020;26:e922585. https://doi.org/10.12659/MSM.922585.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Obayashi M, Shibasaki Y, Koakutsu T, Hayashi Y, Shoji T, Hirayama K, et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells curatively resected after pembrolizumab therapy for lung metastases: a case report. BMC Gastroenterol. 2020;20(1):220. https://doi.org/10.1186/s12876-020-01362-4.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Yang G, Yin J, Ou K, du Q, Ren W, Jin Y, et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas harboring KRAS and BRCA mutations: case report and whole exome sequencing analysis. BMC Gastroenterol. 2020;20(1):202. https://doi.org/10.1186/s12876-020-01351-7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Nehmeh WA, Trak-Smayra V, Tarhini A, Gabriel MF, Sayegh RB, Noun R. A case report presenting an undifferentiated pancreatic carcinoma with osteoclastic-like giant cells with an unusual indolent course. Am J Case Rep. 2019;20:1750–4. https://doi.org/10.12659/AJCR.916810.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Abid H, Gnanajothy R. Osteoclast giant cell tumor of pancreas: a case report and literature review. Cureus. 2019;11(5):e4710. https://doi.org/10.7759/cureus.4710.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Zhang L. Undifferentiated pancreatic carcinoma with osteoclast-like giant cells. Diagn Interv Radiol. 2019;25(2):173–4. https://doi.org/10.5152/dir.2019.18261.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Fan X, Wang W, Li C, Tang T, Han Y, An K. An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review. Medicine (Baltimore). 2019;98(16):e15246. https://doi.org/10.1097/MD.0000000000015246.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Guo YL, Ruan LT, Wang QP, Lian J. Undifferentiated carcinoma with osteoclast-like giant cells of pancreas: a case report with review of the computed tomography findings. Medicine (Baltimore). 2018;97(48):e13516. https://doi.org/10.1097/MD.0000000000013516.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Sakhi R, Hamza A, Khurram MS, Ibrar W, Mazzara P. Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells reported in an asymptomatic patient: a rare case and literature review. Autops Case Rep. 2017;7(4):51–7. https://doi.org/10.4322/acr.2017.042.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Fu LP, Cheng AP, Wang XG, Fu JL, Jin L. 18F-FDG PET/CT in the detection of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas. Clin Nucl Med. 2017;42(8):615–6. https://doi.org/10.1097/RLU.0000000000001719.

    Article  PubMed  Google Scholar 

  24. Saito H, Kashiyama H, Murohashi T, Sasaki K, Misawa R, Ohwada S. Case of six-year disease-free survival with undifferentiated carcinoma of the pancreas. Case Rep Gastroenterol. 2016;10(2):472–8. https://doi.org/10.1159/000448878.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Nitta T, Fujii K, Kataoka J, Tominaga T, Kawasaki H, Ishibashi T. A case of long-term 24-month survival in pancreatic anaplastic carcinoma (giant cell type) after S1 postoperative adjuvant chemotherapy. Int J Surg Case Rep. 2016;23:134–7. https://doi.org/10.1016/j.ijscr.2016.04.013.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Lahiff C, Swan N, Conlon K, Malone D, Maguire D, Hoti E, et al. Osteoclastic-type giant cell tumours of the pancreas: a homogenous series of rare tumours diagnosed by endoscopic ultrasound. Dig Surg. 2016;33:401–5. https://doi.org/10.1159/000445303.

    Article  PubMed  Google Scholar 

  27. Sah SK, Li Y, Li Y. Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a rare case report and review of the literature. Int J ClinExpPathol. 2015;8(9):11785–91.

    Google Scholar 

  28. Temesgen WM, Wachtel M, Dissanaike S. Osteoclastic giant cell tumor of the pancreas. Int J Surg Case Rep. 2014;5(4):175–9. https://doi.org/10.1016/j.ijscr.2014.01.002.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Maksymov V, Khalifa MA, Bussey A, Carter B, Hogan M. Undifferentiated (anaplastic) carcinoma of the pancreas with osteoclast-like giant cells showing various degree of pancreas duct involvement. A case report and literature review. JOP. 2011;12(2):170–6.

    PubMed  Google Scholar 

  30. Moore JC, Hilden K, Bentz JS, Pearson RK, Adler DG. Osteoclastic and pleomorphic giant cell tumors of the pancreas diagnosed via EUS-guided FNA: unique clinical, endoscopic, and pathologic findings in a series of 5 patients. GastrointestEndosc. 2009;69(1):162–6. https://doi.org/10.1016/j.gie.2008.08.025.

    Article  Google Scholar 

  31. Manduch M, Dexter DF, Jalink DW, Vanner SJ, Hurlbut DJ. Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: report of a case with osteochondroid differentiation. Pathol Res Pract. 2009;205(5):353–9. https://doi.org/10.1016/j.prp.2008.11.006.

    Article  PubMed  Google Scholar 

  32. Osaka H, Yashiro M, Nishino H, Nakata B, Ohira M, Hirakawa K. A case of osteoclast-type giant cell tumor of the pancreas with high-frequency microsatellite instability. Pancreas. 2004;29(3):239–41. https://doi.org/10.1097/00006676-200410000-00010.

    Article  PubMed  Google Scholar 

  33. Leighton CC, Shum DT. Osteoclastic giant cell tumor of the pancreas: case report and literature review. Am J Clin Oncol. 2001;24(1):77–80. https://doi.org/10.1097/00000421-200102000-00014.

    Article  CAS  PubMed  Google Scholar 

  34. Luchini C, Cros J, Pea A, Pilati C, Veronese N, Rusev B, et al. PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications. Hum Pathol. 2018;81:157–65. https://doi.org/10.1016/j.humpath.2018.07.006.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank the medical and nursing teams for their management of the patient.

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AK performed the data extraction and wrote the various sections of the manuscript. TE and TB contributed by checking data extraction and the pathological findings of the manuscript. BS participated in drafting the article, revising it critically and giving final approval of the version to be submitted. All authors read and approved the final version of the manuscript.

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Correspondence to Ayoub Kharkhach.

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Kharkhach, A., Bouhout, T., Serji, B. et al. Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis. J Gastrointest Canc 52, 1106–1113 (2021). https://doi.org/10.1007/s12029-021-00583-4

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