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Association Between the hOGG1 1245C>G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analysis Based on 7010 Cases and 10,674 Controls

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Abstract

Background

The 1245C>G (rs1052133) polymorphism of human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene has been indicated to be correlated with colorectal (CRC) susceptibility, but studies have yielded conflicting results. Thus, the present meta-analysis was performed to derive a more precise estimation between hOGG1 1245C>G polymorphism and CRC risk.

Methods

Data were collected from several electronic databases such as PubMed, EMBASE, and Google Scholar databases, with the last search up to September 01, 2020. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the association.

Results

A total of 24 case-control studies with 7010 CRC cases and 10,674 controls were selected. Pooled data showed that the hOGG1 1245C>G polymorphism was significantly associated with CRC risk under three genetic models, i.e., homozygote (GG vs. CC: OR = 1.229, 95% CI 1.031–1.465, p = 0.022); heterozygote (GC vs. CC: OR = 1.142, 95% CI 1.008–1.294, p = 0.037); and dominant (GG+GC vs. CC: OR = 1.162, 95% CI 1.034–1.304, p = 0.011). When stratified analysis by ethnicity, a significant association of the hOGG1 1245C>G polymorphism with risk of CRC was found in the Caucasians, but not in Asians. Moreover, there were significant associations between hOGG1 1245C>G polymorphism and CRC by PCR-RFLP and hospital-based subgroups.

Conclusions

Inconsistent with the previous meta-analysis, these meta-analysis results revealed that the hOGG1 1245C>G polymorphism might be associated with an increased risk of CRC, especially in Caucasians.

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Acknowledgments

I would like to express my sincere gratitude to Professor Mohammad Hasan Sheikhha for his motivation, knowledge, and support during the course of this research.

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Authors and Affiliations

  1. Clinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Yaser Ghelmani

  2. Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran

    Fatemeh Asadian

  3. Department of Internal Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran

    Mohammad Hossein Antikchi

  4. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Alireza Dastgheib

  5. Department of Emergency Medicine, Iran University of Medical Sciences, Tehran, Iran

    Seyed Hossein Shaker

  6. Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Jamal Jafari-Nedooshan

  7. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh

  8. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hossein Neamatzadeh

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  1. Yaser Ghelmani
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Contributions

Y.G. and F.A. are responsible as the guarantor of integrity of the entire study, study design and concepts, definition of intellectual content, and literature research. M.H.A. and S.A.D. are responsible for the clinical studies, experimental studies, data acquisition, and manuscript preparation. S.H.S and J.J.N. are responsible for the data analysis, statistical analysis, and manuscript review. H.N and Y.G are responsible for the manuscript editing. All authors have read and agreed with the final version of this manuscript.

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Correspondence to Fatemeh Asadian.

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An ethical approval or patient consent was not needed because this is a meta-analysis in which all data were extracted from published literature.

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Ghelmani, Y., Asadian, F., Antikchi, M.H. et al. Association Between the hOGG1 1245C>G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analysis Based on 7010 Cases and 10,674 Controls. J Gastrointest Canc 52, 389–398 (2021). https://doi.org/10.1007/s12029-020-00532-7

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