Skip to main content

Advertisement

SpringerLink
Log in

Ampullary Adenocarcinoma: a Mini-Review and a Case Report of a Clinically Stable Disease Patient Treated with Herbal Supplements

  • Case Report
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Allard-Picou A. Ampullary carcinoma: practice essentials, Background, Pathophysiology. 2019. https://emedicine.medscape.com/article/276413-overview. Accessed 21 July 2020.

  2. He J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA, et al. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB. 2014;16(1):83–90. https://doi.org/10.1111/hpb.12078.

    Article  PubMed  Google Scholar 

  3. Yeo CJ, Cameron JL, Sohn TA, Lillemoe KD, Pitt HA, Talamini MA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg. 1997;226(3):248–60. https://doi.org/10.1097/00000658-199709000-00004.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Albores-Saavedra J, Schwartz AM, Batich K, Henson DE. Cancers of the ampulla of Vater: demographics, morphology, and survival based on 5,625 cases from the SEER program: cancer of the ampulla of Vater. J Surg Oncol. 2009;100(7):598–605. https://doi.org/10.1002/jso.21374.

    Article  PubMed  Google Scholar 

  5. Rostain F. Trends in incidence and management of cancer of the ampulla of Vater. World J Gastroenterol. 2014;20(29):10144. https://doi.org/10.3748/wjg.v20.i29.10144.

    Article  PubMed  PubMed Central  Google Scholar 

  6. He X-D, Wu Q, Liu W, Hong T, Li JJ, Miao RY, et al. Association of metabolic syndromes and risk factors with ampullary tumors development: a case-control study in China. World J Gastroenterol. 2014;20(28):9541–8. https://doi.org/10.3748/wjg.v20.i28.9541.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ray-Offor E. Periampullary cancer and cancer in head of pancreas: what is the difference? Gastroenterol Hepatol Endosc. 2019;4(3):1–3. https://doi.org/10.15761/GHE.1000184.

    Article  Google Scholar 

  8. Mccarthy MJ, Evans J, Sagar G, Neoptolemos JP. Prediction of resectability of pancreatic malignancy by computed tomography. Br J Surg. 1998;85(3):320–5. https://doi.org/10.1046/j.1365-2168.1998.00584.x.

    Article  CAS  PubMed  Google Scholar 

  9. Pancreatic Section of the British Society of Gastroenterology, Pancreatic Society of Great Britain and Ireland, Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, Royal College of Pathologists, Special Interest Group for Gastro-I. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut. 2005;54(suppl_5):v1–16. https://doi.org/10.1136/gut.2004.057059.

    Article  Google Scholar 

  10. Hornick JR, Johnston FM, Simon PO, Younkin M, Chamberlin M, Mitchem JB, et al. A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater: management and outcomes. Surg. 2011;150(2):169–76. https://doi.org/10.1016/j.surg.2011.05.012.

    Article  Google Scholar 

  11. Klein F, Jacob D, Bahra M, et al. Prognostic factors for long-term survival in patients with ampullary carcinoma: the results of a 15-year observation period after pancreaticoduodenectomy. HPB Surg. 2014;2014:970234. https://doi.org/10.1155/2014/970234.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kawamata H, Yamashita K, Nakamura K, Katagiri H, Ishii K, Takahashi Y, et al. Perineural invasion and preoperative serum CA19-9 as predictors of survival in biliary tract cancer. Anticancer Res. 2013;33:583–94.

    PubMed  Google Scholar 

  13. Lee HS, Jang JS, Lee S, Yeon MH, Kim KB, Park JG, et al. Diagnostic accuracy of the initial endoscopy for ampullary tumors. Clin Endosc. 2015;48(3):239–46. https://doi.org/10.5946/ce.2015.48.3.239.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Patel V, Jowell P, Obando J, Guy C, Burbridge R. Does ampullary adenoma size predict invasion on EUS? Does invasion on EUS predict presence of malignancy? Endosc Int Open. 2016;04(12):E1313–8. https://doi.org/10.1055/s-0042-121001.

    Article  Google Scholar 

  15. Manta R. Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors. World J Gastroenterol. 2010;16(44):5592–7. https://doi.org/10.3748/wjg.v16.i44.5592.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ridtitid W, Schmidt SE, Al-Haddad MA, LeBlanc J, DeWitt JM, McHenry L, et al. Performance characteristics of EUS for locoregional evaluation of ampullary lesions. Gastrointest Endosc. 2015;81(2):380–8. https://doi.org/10.1016/j.gie.2014.08.005.

    Article  PubMed  Google Scholar 

  17. Buscail L, Pagès P, Berthélemy P, Fourtanier G, Frexinos J, Escourrou J. Role of EUS in the management of pancreatic and ampullary carcinoma: a prospective study assessing resectability and prognosis. Gastrointest Endosc. 1999;50(1):34–40. https://doi.org/10.1016/s0016-5107(99)70341-x.

    Article  CAS  PubMed  Google Scholar 

  18. Dacha S, Chawla S, Lee JE, Keilin SA, Cai Q, Willingham FF. Endoscopic retrograde cholangiopancreatography with ampullary biopsy vs ERCP alone: a matched-pairs controlled evaluation of outcomes and complications. Gastroenterol Rep (Oxf). 2017;5(4):277–81. https://doi.org/10.1093/gastro/gow044.

    Article  Google Scholar 

  19. Agoff SN, Crispin DA, Bronner MP, Dail DH, Hawes SE, Haggitt RC. Neoplasms of the ampulla of Vater with concurrent pancreatic intraductal neoplasia: a histological and molecular study. Mod Pathol. 2001;14(3):139–46. https://doi.org/10.1038/modpathol.3880270.

    Article  CAS  PubMed  Google Scholar 

  20. Zimmermann C, Wolk S, Aust DE, Meier F, Saeger H-D, Ehehalt F, et al. The pathohistological subtype strongly predicts survival in patients with ampullary carcinoma. Sci Rep. 2019;9(1):12676. https://doi.org/10.1038/s41598-019-49179-w.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, et al. Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg. 2008;15(1):41–54. https://doi.org/10.1007/s00534-007-1279-5.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Gao Y, Zhu Y, Huang X, Wang H, Huang X, Yuan Z. Transduodenal ampullectomy provides a less invasive technique to cure early ampullary cancer. BMC Surg. 2016;16(1):36. https://doi.org/10.1186/s12893-016-0156-z.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Tran TC. Ampullary tumors: endoscopic versus operative management. Surg Innov. 2004;11(4):255–63. https://doi.org/10.1177/155335060401100409.

    Article  PubMed  Google Scholar 

  24. Yoon Y-S, Kim S-W, Park SJ, Lee HS, Jang J-Y, Choi MG, et al. Clinicopathologic analysis of early ampullary cancers with a focus on the feasibility of ampullectomy. Ann Surg. 2005;242(1):92–100. https://doi.org/10.1097/01.sla.0000167853.04171.bb.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Song J, Liu H, Li Z, Yang C, Sun Y, Wang C. Long-term prognosis of surgical treatment for early ampullary cancers and implications for local ampullectomy. BMC Surg. 2015;15(1):32. https://doi.org/10.1186/s12893-015-0019-z.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Bhatia S, Miller RC, Haddock MG, Donohue JH, Krishnan S. Adjuvant therapy for ampullary carcinomas: the Mayo Clinic experience. Int J Radiat Oncol Biol Phys. 2006;66(2):514–9. https://doi.org/10.1016/j.ijrobp.2006.04.018.

    Article  PubMed  Google Scholar 

  27. Sikora SS, Balachandran P, Dimri K, Rastogi N, Kumar A, Saxena R, et al. Adjuvant chemo-radiotherapy in ampullary cancers. Eur J Surg Oncol. 2005;31(2):158–63. https://doi.org/10.1016/j.ejso.2004.08.013.

    Article  CAS  PubMed  Google Scholar 

  28. Klinkenbijl JH, Jeekel J, Sahmoud T, van Pel R, Couvreur ML, Veenhof CH, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group. Ann Surg. 1999;230(6):776–82. https://doi.org/10.1097/00000658-199912000-00006.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Willett CG, Warshaw AL, Convery K, Compton CC. Patterns of failure after pancreaticoduodenectomy for ampullary carcinoma. Surg Gynecol Obstet. 1993;176(1):33–8.

    CAS  PubMed  Google Scholar 

  30. Zhou J, Hsu CC, Winter JM, Pawlik TM, Laheru D, Hughes MA, et al. Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of Vater. Radiother Oncol. 2009;92(2):244–8. https://doi.org/10.1016/j.radonc.2009.05.006.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Ecker BL, Vollmer CM, Behrman SW, Allegrini V, Aversa J, Ball CG, et al. Role of adjuvant multimodality therapy after curative-intent resection of ampullary carcinoma. JAMA Surg. 2019;154(8):706–14. https://doi.org/10.1001/jamasurg.2019.1170.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Nassour I, Hynan LS, Christie A, Minter RM, Yopp AC, Choti MA, et al. Association of adjuvant therapy with improved survival in ampullary cancer: a national cohort study. J Gastrointest Surg. 2018;22(4):695–702. https://doi.org/10.1007/s11605-017-3624-6.

    Article  PubMed  Google Scholar 

  33. Morak MJM, van der Gaast A, Incrocci L, van Dekken H, Hermans JJ, Jeekel J, et al. Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. Ann Surg. 2008;248(6):1031–41. https://doi.org/10.1097/sla.0b013e318190c53e.

    Article  PubMed  Google Scholar 

  34. Study Group of Surgical Adjuvant Therapy for Carcinomas of the Pancreas and Biliary Tract, Takada T, Amano H, Yasuda H, Nimura Y, Matsushiro T, et al. Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma?: a phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer. 2002;95(8):1685–95. https://doi.org/10.1002/cncr.10831.

    Article  Google Scholar 

  35. Barton RM, Copeland EM. Carcinoma of the ampulla of Vater. Surg Gynecol Obstet. 1983;156(3):297–301.

    CAS  PubMed  Google Scholar 

  36. Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, et al. Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA. 2012;308(2):147–56. https://doi.org/10.1001/jama.2012.7352.

    Article  CAS  PubMed  Google Scholar 

  37. Chan C, Quintanilla-Martinez L, Richaud-Patin Y, Llorente L, Robles-Diaz G, Campuzano M. Clinical behavior and prognostic factors of periampullary adenocarcinoma. Ann Surg. 1995;222(5):632–7. https://doi.org/10.1097/00000658-199511000-00005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Jiang Z-Q, Varadhachary G, Wang X, Kopetz S, Lee JE, Wang H, et al. A retrospective study of ampullary adenocarcinomas: overall survival and responsiveness to fluoropyrimidine-based chemotherapy. Ann Oncol. 2013;24(9):2349–53. https://doi.org/10.1093/annonc/mdt191.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Cen P, Wray CJ, Zhang S, Thosani NC, Dinh BC, Gonzalez A, et al. Durable response for ampullary and duodenal adenocarcinoma with a nab-paclitaxel plus gemcitabine ± cisplatin combination. Cancer Med. 2019;8(7):3464–70. https://doi.org/10.1002/cam4.2181.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Saito H, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, et al. Radiation therapy and photodynamic therapy for biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg. 2008;15(1):63–8. https://doi.org/10.1007/s00534-007-1281-y.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Park HM, Park S-J, Han S-S, Hong SK, Hong EK, Kim S-W. Very early recurrence following pancreaticoduodenectomy in patients with ampullary cancer. Med. 2019;98(44):e17711. https://doi.org/10.1097/md.0000000000017711.

    Article  CAS  Google Scholar 

  42. Hatzaras I, George N, Muscarella P, Melvin WS, Ellison EC, Bloomston M. Predictors of survival in periampullary cancers following pancreaticoduodenectomy. Ann Surg Oncol. 2010;17(4):991–7. https://doi.org/10.1245/s10434-009-0883-9.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Chang DK, Jamieson NB, Johns AL, Scarlett CJ, Pajic M, Chou A, et al. Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of Vater. J Clin Oncol. 2013;31(10):1348–56. https://doi.org/10.1200/jco.2012.46.8868.

    Article  PubMed  Google Scholar 

  44. Choi W, An S, Kwon E, Eo W, Lee S. Impact of standardized allergen-removed Rhus verniciflua Stokes extract on advanced adenocarcinoma of the ampulla of Vater: a case series. Evid Based Complement Altern Med. 2013;2013:1–8. https://doi.org/10.1155/2019/6497691.

    Article  Google Scholar 

  45. Werthmann PG, Kempenich R, Lang-Avérous G, Kienle GS. Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with Viscum album extracts: a case report. World J Gastroenterol. 2019;25(12):1524–30. https://doi.org/10.3748/wjg.v25.i12.1524.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Kiran TGS, Kolakota RK. Role of chamomile in cancer treatment. J Pathol Clin Med Res. 2018;1:001.

    Google Scholar 

  47. Shankar E, Goel A, Gupta K, Gupta S. Plant flavone apigenin: an emerging anticancer agent. Curr Pharmacol Rep. 2017;3(6):423–46. https://doi.org/10.1007/s40495-017-0113-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Hoensch H, Groh B, Edler L, Kirch W. Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence. World J Gastroenterol. 2008;14(14):2187. https://doi.org/10.3748/wjg.14.2187.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Amin ARMR, Karpowicz PA, Carey TE, Arbiser J, Nahta R, Chen ZG, et al. Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Semin Cancer Biol. 2015;35:S55–77. https://doi.org/10.1016/j.semcancer.2015.02.005.

    Article  CAS  PubMed  Google Scholar 

  50. Arora S, Singh S, Piazza GA, Contreras CM, Panyam J, Singh AP. Honokiol: a novel natural agent for cancer prevention and therapy. Curr Mol Med. 2012;12(10):1244–52. https://doi.org/10.2174/156652412803833508.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Arora S, Bhardwaj A, Srivastava SK, Singh S, McClellan S, Wang B, et al. Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. Chandra D, editor. PLoS ONE. 2011;6(6):e21573. https://doi.org/10.1371/journal.pone.0021573.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Songjang W, Jiraviriyakul A. Honokiol and magnolol inhibit growth, metastasis and induce apoptosis in human cholangiocarcinoma. Biomed Pharmacol J. 2019;12(2):759–73. https://doi.org/10.13005/bpj/1698.

    Article  CAS  Google Scholar 

  53. Golkar L, Ding X-Z, Ujiki MB, Salabat MR, Kelly DL, Scholtens D, et al. Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1. J Surg Res. 2007;138(2):163–9. https://doi.org/10.1016/j.jss.2006.05.037.

    Article  CAS  PubMed  Google Scholar 

  54. Ko J-H, Sethi G, Um J-Y, Shanmugam MK, Arfuso F, Kumar AP, et al. The role of resveratrol in cancer therapy. Int J Mol Sci. 2017;18(12):2589. https://doi.org/10.3390/ijms18122589.

    Article  CAS  PubMed Central  Google Scholar 

  55. Liu P, Liang H, Xia Q, Li P, Kong H, Lei P, et al. Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression. Clin Transl Oncol. 2013;15(9):741–6. https://doi.org/10.1007/s12094-012-0999-4.

    Article  CAS  PubMed  Google Scholar 

  56. Lwin KM, Lwin MKT. Vitis species. Yangon: FAME Publishing House; 2012.

    Google Scholar 

  57. Line-Edwige M, Guy Raymond F, François E, Edouard N. Antiproliferative effect of alcoholic extracts of some Gabonese medicinal plants on human colonic cancer cells. Afr J Trad Compl Alt Med. 2010;6(2):112–7.

    Article  Google Scholar 

  58. Gore RD. Wheatgrass: green blood can help to fight cancer. J Clin Diagn Res. 2017;11(6):ZC40–2. https://doi.org/10.7860/JCDR/2017/26316.10057.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Food and Agriculture Organization of the United Nations, World Health Organization (2006) Probiotics in food: health and nutritional properties and guidelines for evaluation. Food and Agriculture Organization of the United Nations: World Health Organization, Rome.

  60. Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, et al. Gut microbiota and cancer: from pathogenesis to therapy. Cancers. 2019;11(1):38. https://doi.org/10.3390/cancers11010038.

    Article  CAS  PubMed Central  Google Scholar 

  61. Nemunaitis J, Cunningham C, Senzer N, Kuhn J, Cramm J, Litz C, et al. Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients. Cancer Gene Ther. 2003;10(10):737–44. https://doi.org/10.1038/sj.cgt.7700634.

    Article  CAS  PubMed  Google Scholar 

  62. Toso JF, Gill VJ, Hwu P, Marincola FM, Restifo NP, Schwartzentruber DJ, et al. Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. J Clin Oncol. 2002;20(1):142–52. https://doi.org/10.1200/jco.2002.20.1.142.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We wish to thank Ms. Su Su Saw and the staffs of the FAME Clinic for their help, advices, and cooperation.

Author information

Authors and Affiliations

  1. FAME Pharmaceuticals Industry Co., Ltd., FAME Clinic, Yangon, Myanmar

    Khin Maung Lwin

  2. Research and Development Department, FAME Pharmaceuticals Industry Co., Ltd., Yangon, Myanmar

    Ye Htut Linn & Yamin Kyaw Swar Dee

Authors
  1. Khin Maung Lwin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ye Htut Linn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yamin Kyaw Swar Dee
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

KML treated the patient. YHL and YMKSD reviewed and wrote the manuscript. KML critically revised the manuscript.

Corresponding author

Correspondence to Ye Htut Linn.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Approval

The local IRB has confirmed that no ethical approval is required for case reports. Consent to participate and consent for publication were taken from the patient. We declared that this manuscript/data has not been published or currently under review for publication elsewhere.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lwin, K.M., Linn, Y.H. & Dee, Y.K.S. Ampullary Adenocarcinoma: a Mini-Review and a Case Report of a Clinically Stable Disease Patient Treated with Herbal Supplements. J Gastrointest Canc 52, 750–758 (2021). https://doi.org/10.1007/s12029-020-00501-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-020-00501-0

Search

Navigation