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Clinicopathological Characteristics and Incidence of Gastric Cancer in Eastern India: A Retrospective Study

  • Original Research
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Purpose

To study the association of gastric cancer with various clinicopathological traits in eastern India which can be used as an important factor for further analysis, understanding of the diseases and amelioration of patients.

Methods

The retrospective study includes the patients who underwent subtotal or total gastrectomy from surgical oncology department of Chittaranjan National Cancer Institute (hospital) of West Bengal, India between 2014 and 2018. The study includes 751 gastric cancer patients from Chittaranjan National Cancer Institute. We used electronic hospital records to collect data on various clinical parameters and other information. We used Microsoft Office Excel 2007 spreadsheets for the statistical analyses.

Results

Incidence of gastric cancer is associated with mid age (40–59 years) group male patients and lymph node metastasis. Frequency of gastric cancer is highest in the antrum (42.21%). Of the mid age group gastric cancer patients, 35.02% were having much high risk of developing diffused type of adenocarcinoma (P < 0.00001). Tobacco intake in form of smoking was found as an important risk factor in gastric cancer development with risk ratio and odds ratio of 1.18 and 3.14 respectively.

Conclusion

Collectively, the results of the present study confirm that incidence of diffused type of gastric cancer is increasing as an alarming rate in mid age group male patients and tobacco intake in the form of smoking as an independent risk factor for this type of cancer in eastern India. This result can be used to manage gastric carcinoma in future prospective clinical studies and in patient’s improvement.

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Data Availability

The data sets generated and/or analyzed during the current study are available in the CNCI repository. The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

WHO:

World Health Organization

GOO:

gastric outlet obstruction

AAR:

age-adjusted incidence rates

OR:

odds ratio

RR:

risk ratio

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Acknowledgments

Dr. Nabendu Murmu sincerely thanks to Dr. Jayanta Chakrabarti, Director, Chittaranjan National Cancer Institute (CNCI), Kolkata, India for his active support.

Funding

This study was supported in part by the Chittaranjan National Cancer Institute, Kolkata, India and funded by University Grants commission of India (grant no. 17-06/2012(i)EU-V, Sr. No. 2061230745).

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Authors and Affiliations

  1. Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700026, India

    Paramita Ghosh & Nabendu Murmu

  2. Department of Epidemiology and Biostatistics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700026, India

    Shyamsundar Mandal

  3. Department of Pathology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700026, India

    Saunak Mitra Mustafi

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  1. Paramita Ghosh
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Contributions

Paramita Ghosh and Nabendu Murmu are responsible for the conception or design of the work. Paramita Ghosh and Shyamsundar Mandal performed the acquisition, analysis, and interpretation of data of the work. Saunak Mitra Mustafi helped in reviewing the histopathology data of this project and provided the data. All authors finally approved the manuscript version to be published. NM is the guarantor of the article. All authors read and approved the final manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Nabendu Murmu.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The study has been approved by the Institutional Ethics Committee (IEC) of Chittaranjan National Cancer Institute, Kolkata, India (IEC Ref: A-4.311/1/2018-2). All the procedures performed in the study were in accordance with the Helsinki declaration and its later amendments.

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Informed consent to participate in the study was obtained from patients/parent/guardian/relative of the patient included in the study.

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Written informed consent for publication of their clinical details was obtained from patients/parent/guardian/relative of the patient. A copy of the consent form is available for review by the editor.

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Ghosh, P., Mandal, S., Mitra Mustafi, S. et al. Clinicopathological Characteristics and Incidence of Gastric Cancer in Eastern India: A Retrospective Study. J Gastrointest Canc 52, 863–871 (2021). https://doi.org/10.1007/s12029-020-00478-w

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