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What About Gastric Schwannoma? A Review Article

  • Review Article
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Abstract

Purpose

Gastric schwannomas (GSs) are rare mesenchymal neoplasms of the gastrointestinal tract. Diagnosis is often achieved postoperatively, based on pathology reports of retrieved specimens. The aim of the present study is to follow up all patients with gastric schwannoma (Gs) undergoing endoscopic, partial, or more extended surgery and to evaluate the appearance of local or distant recurrence.

Methods

A PubMed, Cochrane, and Embase systematic review of the literature has been performed. Original papers, review articles, and case reports published between 1988 and 2019 were considered eligible. All the studies who met the inclusion criteria were analyzed. Statistical analysis of data has been performed using GraphPad Prism 7 software.

Results

Three hundred twenty-eight articles were found, and a total of 102 were included and analyzed in depth. Fifty-three papers reported the follow-up information, ranging from 1 to 417 months across different studies. Among them, 31 patients underwent endoscopic removal of the gastric lesions; 140 patients underwent local surgery, including wedge resection or partial gastrectomy; and 148 patients underwent subtotal or total gastrectomy. The median follow-up was of 27-38-33 months, respectively. No recurrence or distant metastasis was detected in the endoscopy group. Among local surgery group, liver metastasis was reported in one case; in extended surgery group, one patient died for multiple liver metastases.

Conclusions

Local or more extended surgery involved a larger cohort of patients and reported satisfactory long-term results compared with endoscopy group. Surgery in absence of a definite preoperative diagnosis is considered the gold standard treatment for resectable Gs.

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Abbreviations

Gs:

Gastric schwannoma

GIs:

Gastrointestinal schwannomas

GISTs:

Gastrointestinal stromal tumors

SMTs:

Submucosal tumors

EUS:

Endoscopic ultrasonography

CT:

Computed tomography

SMA:

Smooth muscle actin

EUS-FNAB:

Endoscopic ultrasound-guided fine-needle aspiration biopsy

GFAP:

Glial fibrillary acid protein

EFTR:

Full-thickness resection

ESD:

Endoscopic submucosal dissection

EE-L:

Ligation-assisted endoscopic enucleation

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Authors and Affiliations

  1. Department of Colorectal Surgery, Campus Bio-Medico University, Rome, Italy

    Sara Lauricella, Gianluca Mascianà, Erica Mazzotta, Chiara Pagnoni, Saponaro Costanza, Marco Caricato & Gabriella Teresa Capolupo

  2. Department of Surgery for Soft Tissue Sarcoma, Campus Bio-Medico University, Rome, Italy

    Sergio Valeri & Ida Francesca Gallo

  3. Department of Pathology, Campus Bio-Medico University, Rome, Italy

    Lorenza Falcone

  4. Unit of Medical Statistic and Epidemiology, Department of Medicine, Campus Bio-Medico University, Rome, Italy

    Domenico Benvenuto

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  1. Sara Lauricella
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Wrote the first draft of the manuscript. All authors read and approved the final manuscript.

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Lauricella, S., Valeri, S., Mascianà, G. et al. What About Gastric Schwannoma? A Review Article. J Gastrointest Canc 52, 57–67 (2021). https://doi.org/10.1007/s12029-020-00456-2

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