Skip to main content

Advertisement

SpringerLink
Log in

Spatial Epidemiology of Pancreatic Cancer in South Dakota

  • Original Research
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Background

Pancreatic cancer is the fourth leading cause of cancer-related mortality in the United States. Descriptive epidemiology of pancreatic cancer in South Dakota has not been studied before.

Materials and Methods

All cases of pancreatic cancer reported to the SD Cancer Registry between January 2005 and December 2014 were included in the study. Variables collected included demographics, geographical location including county of residence and zip codes, date of diagnosis, date of last contact or follow-up, size and location of the tumor, grade of the tumor, diagnostic modality as well as therapeutic interventions. Log rank test was used to compare survival curves. Kaplan-Meier product limit estimates were provided. Data was analyzed using SAS 9.1.4 software.

Results

One thousand sixty-four cases of pancreatic cancer were reported. Median age was 73 years. Cumulative age-adjusted incidence rate for pancreatic cancer for 2005–2014 was 11.1. Cumulative age-adjusted mortality rate for pancreatic cancer for 2005–2014 was 10.2. Almost half of these patients had distant metastasis at the time of presentation (n = 536; 50.4%). Overall, median survival was 5 months. Median survival for patients under the age of 60 years was 9.5 months as opposed to median survival for patients 60 years or older which was 3.9 months. Median survival of patients with well-differentiated, moderately differentiated, and poorly differentiated tumors, was 20.8 months, 8.2 months and 6.3 months respectively (p value = 0.0017).

Conclusion

Incidence of pancreatic cancer in South Dakota is similar to the national trends in the United States. Age at presentation, location of tumor in pancreas, and biological behavior of tumor were all predictors of survival in patients with pancreatic cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Cancer facts and figures. 2017. Retrieved from https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-tatistics/annual-cancer-facts-and-figures/2017/cancer-facts-andfigures-2017.pdf

  2. Mokdad AH, Dwyer-Lindgren L, Fitzmaurice C, Stubbs RW, Bertozzi-Villa A, Morozoff C, et al. Trends and patterns of disparities in cancer mortality among US counties, 1980-2014. JAMA. 2017;317(4):388–406.

    Article  Google Scholar 

  3. Etxeberria J, Goicoa T, López-Abente G, Riebler A, Ugarte MD. Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990-2013). PLoS One. 2017;12(2):e0169751. https://doi.org/10.1371/journal.pone.0169751.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Liu-Mares W, Mackinnon JA, Sherman R, Fleming LE, Rocha-Lima C, Hu JJ, et al. Pancreatic cancer clusters and arsenic-contaminated drinking water wells in Florida. BMC Cancer. 2013;13:111. https://doi.org/10.1186/1471-2407-13-111.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Brotherton L, Welton M, Robb SW. Racial disparities of pancreatic cancer in Georgia: a county-wide comparison of incidence and mortality across the state, 2000-2011. Cancer Med. 2016;5(1):100–10.

    Article  Google Scholar 

  6. Zhan FB, Lin H. Geographic patterns of cancer mortality clusters in Texas, 1990 to 1997. Tex Med. 2003;99(8):58–64.

    PubMed  Google Scholar 

  7. South Dakota Cancer Incidence and Mortality. Available at http://www.sdcancerstats.org/#&&/wEXAQULYWpheEhpc3RvcnkFD0hhcmRpbmcsTGluY29sbhrP4t3DYY6Z+cXpOiIs1tRpfb1LQkF9g6HQXvQv4ftu

  8. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer. Accessed 2016-03-04. Available from: http://globocan.iarc.fr.

  9. American Cancer Society. Key statistics for pancreatic cancer. Retrieved from https://www.cancer.org/cancer/pancreatic-cancer/about/key-statistics.html

  10. Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2016) SEER Cancer statistics review, 1975–2013, National Cancer Institute. Bethesda, MD. Available from: http://seer.cancer.gov/csr/1975_2013/

  11. Hidalgo M, Cascinu S, Kleeff J, Labianca R, Löhr JM, Neoptolemos J, et al. Addressing the challenges of pancreatic cancer: futuredirections for improving outcomes. Pancreatology. 2013;15:8–18.

    Article  Google Scholar 

  12. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet. 2011;378:607–20.

    Article  Google Scholar 

  13. Malvezzi M, Carioli G, Bertuccio P, Rosso T, Boffetta P, Levi F, et al. European cancer mortality predictions for the year 2016 with focus on leukaemias. Ann Oncol. 2016;27:725–31.

    Article  CAS  Google Scholar 

  14. Silverman DT, Schiffman M, Everhart J, Goldstein A, Lillemoe KD, Swanson GM, et al. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer. 1999;80:1830–7.

    Article  CAS  Google Scholar 

  15. Schenk M, Schwartz AG, O’Neal E, et al. Familial risk of pancreatic cancer. J Natl Cancer Inst. 2001;93:640–4.

    Article  CAS  Google Scholar 

  16. Brune KA, Lau B, Palmisano E, et al. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst. 2010;102:119–26.

    Article  Google Scholar 

  17. Gong Z, Holly EA, Bracci PM. Survival in population-based pancreatic cancer patients: San Francisco Bay area, 1995-1999. Am J Epidemiol. 2011;174:1373–81.

    Article  Google Scholar 

  18. Sun H, Ma H, Hong G, Sun H, Wang J. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 1981-2010. Sci Rep. 2014;4:6747.

    Article  CAS  Google Scholar 

  19. Artinyan A, Soriano PA, Prendergast C, Low T, Ellenhorn JD, Kim J. The anatomic location of pancreatic cancer is a prognostic factor for survival. HPB. 2008;10:371–6.

    Article  Google Scholar 

  20. Satoi S, Yanagimoto H, Yamamoto T, Toyokawa H, Hirooka S, Yamaki S, et al. A clinical role of staging laparoscopy in patients with radiographically defined locally advanced pancreatic ductal adenocarcinoma. World J Surg Oncol. 2016;14(1):14.

    Article  Google Scholar 

  21. Vieira V, Webster T, Weinberg J, Aschengrau A. Spatial analysis of bladder, kidney, and pancreatic cancer on upper Cape Cod: an application of generalized additive models to case-control data. Environ Health. 2009;8:3.

    Article  Google Scholar 

  22. Ozonoff D, Aschengrau A, Coogan P. Cancer in the vicinity of a Department of Defense superfund site in Massachusetts. Toxicol Ind Health. 1994;10(3):119–41.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would especially like to thank the SD Department of Health for their assistance with data acquisition, procurement, and calculations.

Author information

Authors and Affiliations

  1. Sanford Health, Sioux Falls, SD, USA

    Muslim Atiq

  2. Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA

    Muslim Atiq

  3. South Dakota Department of Health, Pierre, SD, USA

    Kay Dosch & Ashley Miller

  4. Department of Public Health, University of South Dakota, Vermillion, SD, USA

    Ramu G. Sudhagoni

Authors
  1. Muslim Atiq
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kay Dosch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ashley Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ramu G. Sudhagoni
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Muslim Atiq.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Atiq, M., Dosch, K., Miller, A. et al. Spatial Epidemiology of Pancreatic Cancer in South Dakota. J Gastrointest Canc 51, 144–151 (2020). https://doi.org/10.1007/s12029-019-00214-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-019-00214-z

Keywords

Search

Navigation