Skip to main content

Advertisement

Log in

Hepatocellular Carcinoma with Orbital Metastasis: a Unique Multidisciplinary Case Report

  • Case Report
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C. Globcan 2008 v2. 0. Cancer incidence and mortality worldwide: IARC Cancer Base No. 10. Lyon, France. International Agency for Research on Cancer. 2010, Accessed: May 5th, 2018: http://globocan.iarc.fr.

  2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30. https://doi.org/10.3322/caac.21332.

    Article  PubMed  Google Scholar 

  3. Gupta R, Honavar SG, Vemuganti GK. Orbital metastasis from hepatocellular carcinoma. Surv Ophthalmol. 2005;50:485–9. https://doi.org/10.1016/j.survophthal.2005.06.014.

    Article  PubMed  Google Scholar 

  4. Eldesouky MA, Elbakary MA, Shalaby OE, Shareef MM. Orbital metastasis from hepatocellular carcinoma: report of 6 cases. Ophthalmic Plast Reconstr Surg. 2014;30:78–82. https://doi.org/10.1097/IOP.0b013e31829f3a57.

    Article  Google Scholar 

  5. Quick AM, Bloomston M, Kim EY, Hall NC, Mayr NA. Complete response to radiation therapy of orbital metastasis from hepatocellular carcinoma. World J Gastroenterol: WJG. 2009;15:6000–3. https://doi.org/10.3748/wjg.15.6000.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Petrick JL, Braunlin M, Laversanne M, Valery PC, Bray F, McGlynn KA. International trends in liver cancer incidence, overall and by histologic subtype, 1978–2007. Int J Cancer. 2016;139:1534–45. https://doi.org/10.1002/ijc.30211.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Makarova-Rusher OV, Altekruse SF, McNeel TS, Ulahannan S, Duffy AG, Graubard BI, et al. Population attributable fractions of risk factors for hepatocellular carcinoma in the United States. Cancer. 2016;122:1757–65. https://doi.org/10.1002/cncr.29971.

    Article  PubMed  Google Scholar 

  8. Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67:358–80. https://doi.org/10.1002/hep.29086.

    Article  PubMed  Google Scholar 

  9. Zhang B-H, Yang B-H, Tang Z-Y. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol. 2004;130:417–22. https://doi.org/10.1007/s00432-004-0552-0.

    Article  PubMed  Google Scholar 

  10. Song P, Cai Y, Tang H, Li C, Huang J. The clinical management of hepatocellular carcinoma worldwide: a concise review and comparison of current guidelines from 2001 to 2017. Bioscience Trends. 2017;11:389–98. https://doi.org/10.5582/bst.2017.01202.

    Article  PubMed  Google Scholar 

  11. Aleman S, Rahbin N, Weiland O, Davidsdottir L, Hedenstierna M, Rose N, et al. A risk for hepatocellular carcinoma persists long-term after sustained virologic response in patients with hepatitis C-associated liver cirrhosis. Clin Infect Dis. 2013;57:230–6. https://doi.org/10.1093/cid/cit234.

    Article  CAS  PubMed  Google Scholar 

  12. Ogawa E, Furusyo N, Kajiwara E, Takahashi K, Nomura H, Maruyama T, et al. Efficacy of pegylated interferon alpha-2b and ribavirin treatment on the risk of hepatocellular carcinoma in patients with chronic hepatitis C: a prospective, multicenter study. J Hepatol. 2013;58:495–501. https://doi.org/10.1016/j.jhep.2012.10.017.

    Article  CAS  PubMed  Google Scholar 

  13. Kim S, Chun M, Wang H, Cho S, Oh YT, Kang SH, et al. Bone metastasis from primary hepatocellular carcinoma: characteristics of soft tissue formation. Cancer Res Treat. 2007;39:104–8. https://doi.org/10.4143/crt.2007.39.3.104.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378–90. https://doi.org/10.1056/NEJMoa0708857.

    Article  CAS  PubMed  Google Scholar 

  15. Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25–34. https://doi.org/10.1016/S1470-2045(08)70285-7.

    Article  CAS  PubMed  Google Scholar 

  16. Bruix J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, et al. Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2017;389:56–66. https://doi.org/10.1016/S0140-6736(16)32453-9.

    Article  CAS  PubMed  Google Scholar 

  17. El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 2017;389:2492–502. https://doi.org/10.1016/S0140-6736(17)31046-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matthew Michael Sochat.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study, when applicable.

Additional information

We verify that all authors had equal access to the data and played a role in the writing of this manuscript.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sochat, M.M., Piao, J. & Poddar, N. Hepatocellular Carcinoma with Orbital Metastasis: a Unique Multidisciplinary Case Report. J Gastrointest Canc 50, 978–982 (2019). https://doi.org/10.1007/s12029-018-0159-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-018-0159-3

Keywords

Navigation