Perianal Basal Cell Carcinoma: a Case Report

  • Marshall W. Meeks
  • Shane Grace
  • Grace Montenegro
  • Martin W. Schoen
  • Danielle Carpenter
  • Jin-Ping Lai
  • Nishant Poddar
Case Report


Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer and highest incidence of any malignancy in the USA [1]. It usually arises in the elderly on sun-exposed areas, such as the head and neck [2]. The most important etiologic factor for the development of BCC is ultraviolet light exposure; thus, it is very rare for BCC to arise within the anogenital region or other non-UV-exposed areas.

Here, we describe a case of a 49-year-old patient with a perianal skin lesion that presented with painless bleeding. Immunohistochemical staining for Ber-EP4 and BCL2 was positive which demonstrated that the lesion was BCC and not a basaloid squamous cell carcinoma. There have only been a few previously published reports of perianal BCC. While very rare, it is important to highlight this case as it demonstrates the necessity to biopsy suspicious perianal lesions and how to distinguish between basaloid squamous cell carcinoma and BCC.

Case Report

A 49-year-old Caucasian male...



The authors would like to thank Catherine Ellert for the help with manuscript preparation.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there is no conflict of interest.

Informed Consent

Informed consent to publish this study was obtained from the patient.


  1. 1.
    Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. population, 2012. JAMA Dermatol. 2015;151:1081–6.CrossRefPubMedGoogle Scholar
  2. 2.
    Park J, Cho YS, Song KH, Lee JS, Yun SK, Kim HU. Basal cell carcinoma on the pubic area: report of a case and review of 19 Korean cases of BCC from non-sun-exposed areas. Ann Dermatol. 2011;23:405–8.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 2012;166:1069–80.CrossRefPubMedGoogle Scholar
  4. 4.
    Armstrong BK, Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B. 2001;63:8–18.CrossRefPubMedGoogle Scholar
  5. 5.
    Paterson CA, Young-Fadok TM, Dozois RR. Basal cell carcinoma of the perianal region: 20-year experience. Dis Colon Rectum. 1999;42:1200–2.CrossRefPubMedGoogle Scholar
  6. 6.
    Bulur I, Boyuk E, Saracoglu ZN, Arik D. Perianal basal cell carcinoma. Case Rep Dermatol. 2015;7:25–8.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Graham RP, Arnold CA, Naini BV, Lam-Himlin DM. Basaloid squamous cell carcinoma of the anus revisited. Am J Surg Pathol. 2016;40:354–60.CrossRefPubMedGoogle Scholar
  8. 8.
    Damin DC, Rosito MA, Gus P, Tarta C, Weindorfer M, Burger MB, et al. Perianal basal cell carcinoma. J Cutan Med Surg. 2002;6:26–8.CrossRefPubMedGoogle Scholar
  9. 9.
    Patil DT, Goldblum JR, Billings SD. Clinicopathological analysis of basal cell carcinoma of the anal region and its distinction from basaloid squamous cell carcinoma. Mod Pathol. 2013;26:1382–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Wu S, Li WQ, Qureshi AA, Cho E. Alcohol consumption and risk of cutaneous basal cell carcinoma in women and men: 3 prospective cohort studies. Am J Clin Nutr. 2015;102:1158–66.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Reinau D, Surber C, Jick SS, Meier CR. Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities. Br J Cancer. 2014;111:203–6.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Kreuter A, Bechara FG, Stucker M, Brockmeyer NH, Altmeyer P, Wieland U. Perianal basal cell carcinoma—unusual localization of a frequent tumor. J Dtsch Dermatol Ges. 2012;10:59–61.PubMedGoogle Scholar
  13. 13.
    Escutia B, Ledesma E, Serra-Guillen C, Gimeno C, Vilata JJ, Guillen C, et al. Detection of human papilloma virus in normal skin and in superficial and nodular basal cell carcinomas in immunocompetent subjects. J Eur Acad Dermatol Venereol. 2011;25:832–8.CrossRefPubMedGoogle Scholar
  14. 14.
    Gibson GE, Ahmed I. Perianal and genital basal cell carcinoma: a clinicopathologic review of 51 cases. J Am Acad Dermatol. 2001;45:68–71.CrossRefPubMedGoogle Scholar
  15. 15.
    Rivera-Chavarria JP, Vargas-Villalobos F, Riggioni-Viquez S. Bilateral V-Y flap for a perianal basal cell carcinoma: a case report. Int J Surg Case Rep. 2016;24:153–5.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Bulus H, Akyurek O, Akbal E, Yavuz A, Aydin A, Simsek G. Perianal basal cell carcinoma: an uncommon localization. Turk J Gastroenterol. 2014;25(Suppl 1):239–40.PubMedGoogle Scholar
  17. 17.
    Lee HS, Kim SK. Basal cell carcinoma presenting as a perianal ulcer and treated with radiotherapy. Ann Dermatol. 2015;27:212–4.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Lohana P, Creagh T. Reconstruction for basal cell carcinoma in an anatomical region where the sun does not shine: an attractive option! Ann R Coll Surg Engl. 2012;94:e65–7.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Nagendra Naidu DV, Rajakumar V. Perianal basal cell carcinoma-an unusual site of occurrence. Indian J Dermatol. 2010;55:178–80.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Levin AA, Dabade T, Dandekar M, Rogers G, Rosmarin D. Basal cell carcinoma of the perineum. Dermatol Online J. 2014;20Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Marshall W. Meeks
    • 1
  • Shane Grace
    • 1
  • Grace Montenegro
    • 2
  • Martin W. Schoen
    • 1
  • Danielle Carpenter
    • 3
  • Jin-Ping Lai
    • 4
  • Nishant Poddar
    • 1
  1. 1.Department of Internal MedicineSaint Louis University School of MedicineSt LouisUSA
  2. 2.Department of General SurgerySaint Louis University School of MedicineSaint LouisUSA
  3. 3.Department of PathologySaint Louis University School of MedicineSaint LouisUSA
  4. 4.Department of PathologyUniversity of FloridaGainesvilleUSA

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