Recurrent Adult Intraabdominal Undifferentiated High-Grade Pleomorphic Sarcoma Infiltrated the Descending Colon: a Case Report and Review of the Literature
- 12 Downloads
Undifferentiated pleomorphic sarcoma (UPS), which was previously known as malignant fibrous histiocytoma (MFH), was first described in 1961 by Kauffman as a histiocytic tumor with storiform growth in children . On the new 2013 WHO classification of soft-tissue tumors, a new class of “undifferentiated/unclassified sarcoma” was created, with the deletion of MFH replaced by UPS and attributed to this category. UPS is a type of malignant sarcoma that occurs most frequently in patients aged between 50 and 70 years , accounting for 28% of all soft-tissue sarcomas . The major locations for UPS are the lower (49%) and upper extremities (19%), while tumors of the retroperitoneum and abdominal cavity account for 16%, and those of trunk account for 9% of the cases . The histological morphology varies, but the classic form is composed of spindle-shaped and round cells. The prognosis for UPS is very poor because of its strong chances of regional invasiveness and distant...
A special thanks to Jinista Janvee Jankee for the writing assistance.
Statement of Authorship
We hereby certify that all work contained in this manuscript is truthful original work without fabrication, fraud, or plagiarism. This manuscript is not currently under consideration, in press or published elsewhere. We claim full responsibility for the contents of the manuscript.
This work was supported by a grant from the National Natural Science Foundation of China (No. 81400835).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
- 1.Kauffman SL, Stout AP. Histiocytic tumors (fibrous xanthoma and histiocytoma) in children. Cancer. 1961;14(3):469–82. https://doi.org/10.1002/1097-0142(199005/06)14:3<469::AID-CNCR2820140304>3.0.CO;2-Q.CrossRefPubMedGoogle Scholar
- 4.Weiss SW, Enzinger FM. Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer. 1978;41(6):2250–66. https://doi.org/10.1002/1097-0142(197806)41:6<2250::AID-CNCR2820410626>3.0.CO;2-W.CrossRefPubMedGoogle Scholar
- 5.Moradi A, Afsharfard A, Atqiaee K. Undifferentiated Pleomorphic Sarcoma Presenting as Abdominal Pain with a Pulsatile Mass. 2016;2016:8251043–3. https://doi.org/10.1155/2016/8251043.
- 7.Diaz-Beveridge R, Melian M, Zac C, Navarro E, Akhoundova D, Chrivella M, Aparicio J (2015) Primary mesenteric undifferentiated pleomorphic sarcoma masquerading as a colon carcinoma: a case report and review of the literature. Case reports in oncological medicine 2015:532656. https://doi.org/10.1155/2015/532656, 1, 4.
- 8.Shiraev T, Pasricha SS, Choong P, Schlicht S, van Rijswijk CS, Dimmick S, et al. Retroperitoneal sarcomas: a review of disease spectrum, radiological features, characterisation and management. Journal of medical imaging and radiation oncology. 2013;57(6):687–700. https://doi.org/10.1111/1754-9485.12123.CrossRefPubMedGoogle Scholar
- 13.Bekki H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, et al. Phosphorylation of STAT3 in undifferentiated pleomorphic sarcoma is correlated with a favorable prognosis. Pathobiology: journal of immunopathology, molecular and cellular biology. 2016;84(3):161–9. https://doi.org/10.1159/000448524.CrossRefGoogle Scholar
- 14.Lee AY, Agaram NP, Qin LX, Kuk D, Curtin C, Brennan MF, et al. Optimal percent myxoid component to predict outcome in high-grade myxofibrosarcoma and undifferentiated pleomorphic sarcoma. Ann Surg Oncol. 2016;23(3):818–25. https://doi.org/10.1245/s10434-015-5063-5.CrossRefPubMedPubMedCentralGoogle Scholar