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Rupture of Hepatocellular Carcinoma: a Tale of 20 Cases from a Tertiary Care Center in Northern India

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References

  1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014;136:E359–86. https://doi.org/10.1002/ijc.29210.

    Article  CAS  PubMed  Google Scholar 

  2. Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004;127(5 Suppl 1):S35–50. https://doi.org/10.1053/j.gastro.2004.09.014.

    Article  PubMed  Google Scholar 

  3. Bassi N, Caratozzolo E, Bonariol L, et al. Management of ruptured hepatocellular carcinoma: implications of therapy. World J Gastroenterol. 2010;16:1221–5.​ https://doi.org/10.3748/wjg.v16.i10.1221.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Miyamoto M, Sudo T, Kuyama T. Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases. Am J Gastroenterol. 1991;86:67–71.

    CAS  PubMed  Google Scholar 

  5. Clarkston W, Inciardi M, Kirkpatrick S, Mc Ewen G, Ediger S, Schubert T. Acute hemoperitoneum from rupture of a hepatocellular carcinoma. J Clin Gastroenterol. 1988;10(2):221–5. https://doi.org/10.1097/00004836-198804000-00025.

    Article  CAS  PubMed  Google Scholar 

  6. Zhu Q, Li J, Yan JJ, Huang L, Wu MC, Yan YQ. Predictors and clinical outcomes for spontaneous rupture of hepatocellular carcinoma. World J Gastroenterol. 2012;18(48):7302–7. https://doi.org/10.3748/wjg.v18.i48.7302.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Islam M, Deka P, Kapur R, Ansari MM. Non-bleeding spontaneous rupture of hepatocellular carcinoma. Niger J Surg. 2013;19(2):82–4. https://doi.org/10.4103/1117-6806.119241.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Rathod K, Sheth R, Shah P, Rege S. Active contrast extravasation in spontaneous rupture of hepatocellular carcinoma: a rare CT finding. J Postgrad Med. 2000;46(1):35–6. http://www.jpgmonline.com/text.asp?2000/46/1/35/319.

    CAS  PubMed  Google Scholar 

  9. Tanaka A, Takeda R, Mukaihara S, et al. Treatment of ruptured hepatocellular carcinoma. Int J Clin Oncol. 2001;6:291–5. https://doi.org/10.1007/s10147-001-8030-z.

    Article  CAS  PubMed  Google Scholar 

  10. Lai EC, Lau WY. Spontaneous rupture of hepatocellular carcinoma: a systematic review. Arch Surg. 2006;141(2):191–8. https://doi.org/10.1001/archsurg.141.2.191.

    Article  PubMed  Google Scholar 

  11. Yoshida H, Mamada Y, Taniai N, Uchida E. Spontaneous ruptured hepatocellular carcinoma. Hepatol Res. 2016;46:13–21. https://doi.org/10.1111/hepr.12498.

    Article  PubMed  Google Scholar 

  12. Kung CT, Liu BM, Ng SH, Lee TY, Cheng YF, Chen MC, et al. Transcatheter arterial embolization in the emergency department for hemodynamic instability due to ruptured hepatocellular carcinoma: analysis of 167 cases. Am J Roentgenol. 2008;191(6):W231–9. https://doi.org/10.2214/AJR.07.3983.

    Article  Google Scholar 

  13. Bruix J, Sherman M. American Association for the Study of Liver Diseases: management of hepatocellular carcinoma: an update. Hepatology. 2011;53(3):1020–2. https://doi.org/10.1002/hep.24199.

    Article  PubMed  Google Scholar 

  14. Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19:329–38. https://doi.org/10.1055/s-2007-1007122.

    Article  CAS  PubMed  Google Scholar 

  15. Kim HC, Yang DM, Jin W, Park SJ. The various manifestations of ruptured hepatocellular carcinoma: CT imaging findings. Abdom Imaging. 2008;33(6):633–42. https://doi.org/10.1007/s00261-007-9353-7.

    Article  PubMed  Google Scholar 

  16. Singhal M, Sinha U, Kalra N, Duseja A, Khandelwal N. Enucleation sign: a computed tomographic appearance of ruptured hepatocellular carcinoma. J Clin Exp Hepatol. 2016;6(4):335–6. https://doi.org/10.1016/j.jceh.2016.05.004.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Liu CL, Fan ST, Lo CM, et al. Management of spontaneous rupture of hepatocellular carcinoma. Single centre experience. J Clin Oncol. 2001;19:3725–32.

    Article  CAS  PubMed  Google Scholar 

  18. Felicia L, Tan S, Tan Y-M, et al. Factors affecting early mortality in spontaneous rupture of hepatocellular carcinoma. ANZ J Surg. 2006;76:448–52. https://doi.org/10.1111/j.1445-2197.2006.03750.x.

    Article  Google Scholar 

  19. Zhu L, Geng X, Fan S. Relationship between vascular elasticity and spontaneous rupture of hepatocellular carcinoma. Chin-Ger J Clin Oncol. 2003;2(1):18–22.

    Article  CAS  Google Scholar 

  20. Zhu LX, Liu Y, Fan ST. Ultra structural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma. Asian J Surg. 2002;25:157–62.

    Article  PubMed  Google Scholar 

  21. Collaborative Staging Task Force of the American Committee on Cancer. Collaborative Staging Manual and Coding Instructions, version 1.0. Published jointly by the American Joint Committee on Cancer (Chicago, IL) and the U.S. Department of Health and Human Services (Bethesda, Maryland). Bethesda: NIH Publication, 2004; No. 04–5496.

  22. Yun SJ, Nam DH. Hepatic angiographic findings of ruptured hepatocellular carcinoma: “sentinel signs” versus extravasation. J Korean Soc Radiol. 2014;70(5):335–42. https://doi.org/10.3348/jksr.2014.70.5.335.

    Article  Google Scholar 

  23. Tsitouridis I, Michaelides M, Christopoulou A, et al. Early stage of intraperitoneal rupture of hepatocellular carcinoma: CT and MRI evaluation. Ann Gastroenterol. 2007;20(4):282–5.

    Google Scholar 

  24. Zhu LX, Wang GS, Fan ST. Spontaneous rupture of hepatocellular carcinoma. Br J Surg. 1996;83(5):602–7. https://doi.org/10.1002/bjs.1800830507.

    Article  CAS  PubMed  Google Scholar 

  25. Hirai K, Kawazoe Y, Yamashita K, et al. Transcatheter arterial embolization for spontaneous rupture of hepatocellular carcinoma. Am J Gastroenterol. 1986;81:275–9.

    CAS  PubMed  Google Scholar 

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Correspondence to Srimanta Kumar Sahu.

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Informed consent was obtained from all patients. Ethical clearance was obtained from the Institute Ethics Committee of the Post Graduate Institute of Medical Education and Research Chandigarh (PGIMER), India.

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The authors declare no conflict of interest.

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Sahu, S.K., Taneja, S., Kalra, N. et al. Rupture of Hepatocellular Carcinoma: a Tale of 20 Cases from a Tertiary Care Center in Northern India. J Gastrointest Canc 50, 596–600 (2019). https://doi.org/10.1007/s12029-018-0063-x

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  • DOI: https://doi.org/10.1007/s12029-018-0063-x

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