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Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma

Journal of Gastrointestinal Cancer volume 50, pages 304–307 (2019)Cite this article

Abstract

Background

miR-34a has been shown to be involved in P53 regulation. In this study, we aimed to evaluate the expression level of miR-34a in esophageal cancer and compare it with that of the normal marginal tissues.

Methods

Tumor and marginal tissues were obtained from 50 patients with esophageal cancer. After RNA extraction, expression level of miR-34a was determined using SYBR green master mix and real-time quantitative PCR.

Results

It was observed that there was a downregulation of miR-34a in tumoral tissue of esophageal patients in comparison to normal marginal tissues. Moreover, the expression level of miR-34a was correlated with clinicopathological specifications of the patients.

Conclusions

miR-34a may be involved in the pathogenesis and development of esophageal cancer and have the potential to be used as a diagnostic and therapeutic marker in esophageal cancer.

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Fig. 1

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Acknowledgements

We are deeply thankful of our patients for their contribution.

Funding

This study was supported by a grant from research deputy of Tabriz University of Medical Sciences (Grant No. 94-02-15-1424).

Author information

Affiliations

  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Milad Asadi, Dariush Shanehbandi & Hanieh Mohammadpour

  2. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Shahriyar Hashemzadeh & Bita Sepehri

Authors
  1. Milad Asadi
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  2. Dariush Shanehbandi
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  3. Hanieh Mohammadpour
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  4. Shahriyar Hashemzadeh
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Corresponding author

Correspondence to Bita Sepehri.

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The authors declare that they have no conflict of interest.

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Cite this article

Asadi, M., Shanehbandi, D., Mohammadpour, H. et al. Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma. J Gastrointest Canc 50, 304–307 (2019). https://doi.org/10.1007/s12029-018-0060-0

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  • DOI: https://doi.org/10.1007/s12029-018-0060-0

Keywords

  • Esophageal cancer
  • miR-34a
  • Gene expression