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Gastric Gastrointestinal Stromal Tumors (GIST): a Case Series and Current State of the Art in the Workup and Treatment of This Rare Disease

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Funding

This research was supported by The Mirro Center for Research and Innovation and the Parkview Research Center.

Author information

Authors and Affiliations

  1. Parkview Cancer Institute, Advanced Interventional Endoscopy and Endoscopic Oncology, GI Oncology Program, Indiana University, 11104 Parkview Circle, Suite 310, Fort Wayne, IN, 46845, USA

    Neil R. Sharma

  2. Parkview Research Center, 3602 New Vision Drive, Fort Wayne, IN, 46845, USA

    Harishankar Gopakumar & Christina Zelt

  3. Carolinas HealthCare System, 1000 Blythe Blvd, Charlotte, NC, 28203, USA

    Scott Harrison

  4. Purdue University, 202 south River Rd., West Lafayette, IN, 47906, USA

    Natalie Ehmke

Authors
  1. Neil R. Sharma
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  2. Harishankar Gopakumar
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  3. Scott Harrison
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  4. Natalie Ehmke
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  5. Christina Zelt
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Corresponding author

Correspondence to Christina Zelt.

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Research Key Highlights

• Gastrointestinal stromal tumors (GISTs) are uncommon intramural tumors of the GI tract. They are most often seen in the stomach and arise from the muscular layers of the visceral wall.

• The clinical manifestations of GISTs vary depending on the tumor size and location, but are often asymptomatic.

• Advances in endosonography (EUS) and immunohistochemical staining can distinguish these lesions from other intramural and GI tract tumors and are an essential part of the diagnostic and staging workup.

• The advent of EUS-guided fine needle biopsy (FNB) allows for large core tissue acquisition. This has replaced FNA and allowed for histologic analysis of large specimens, increased IHC confirmation, and personalized medicine.

• Treatment involves surgical, endoscopic or hybrid endoscopic-laparoscopic resection. Imatinib may be given, and lesions less than 2 cm may be observed.

• The cases presented in this report represent pathology-confirmed GISTs diagnosed at a large volume, community, tertiary referral GI oncology program during July 2012 through May 2016. Follow-ups for each patient have discovered no recurrences to date.

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Sharma, N.R., Gopakumar, H., Harrison, S. et al. Gastric Gastrointestinal Stromal Tumors (GIST): a Case Series and Current State of the Art in the Workup and Treatment of This Rare Disease. J Gastrointest Canc 50, 548–555 (2019). https://doi.org/10.1007/s12029-017-0034-7

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  • DOI: https://doi.org/10.1007/s12029-017-0034-7

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