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Gastric Gastrointestinal Stromal Tumors (GIST): a Case Series and Current State of the Art in the Workup and Treatment of This Rare Disease

  • Neil R. Sharma
  • Harishankar Gopakumar
  • Scott Harrison
  • Natalie Ehmke
  • Christina Zelt
Case Report
  • 80 Downloads

Background

While the annual incidence of gastrointestinal stromal tumor (GIST) is estimated at only 10–20 per million, it is the most common form of mesenchymal neoplasm of gastrointestinal (GI) tract [1, 2]. Although the majority of GISTs occur in the stomach (60–70%), they can arise anywhere along the GI tract, including the esophagus, small intestine, and colon, as well as in extravisceral locations [3]. In past medical literature, the distinction between GISTs and other non-epithelial tumors of the GI tract had been overlooked; an omission that has since become highly clinically significant.

Unlike leiomyoma’s, which are benign and derive from smooth muscle, GISTs possess the potential for malignancy and are believed to develop from the pacemaker cells of the intestine, otherwise known as the interstitial cells of Cajal [ 4]. It is essential to differentiate the two types of intramural lesions in order to avoid unnecessary invasive treatments. The reported incidence of GIST has...

Notes

Funding information

This research was supported by The Mirro Center for Research and Innovation and the Parkview Research Center.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Neil R. Sharma
    • 1
  • Harishankar Gopakumar
    • 2
  • Scott Harrison
    • 3
  • Natalie Ehmke
    • 4
  • Christina Zelt
    • 2
  1. 1.Parkview Cancer Institute, Advanced Interventional Endoscopy and Endoscopic Oncology, GI Oncology ProgramIndiana UniversityFort WayneUSA
  2. 2.Parkview Research CenterFort WayneUSA
  3. 3.Carolinas HealthCare SystemCharlotteUSA
  4. 4.Purdue UniversityWest LafayetteUSA

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