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Epidermal Inclusion Cyst in an Intra-pancreatic Accessory Spleen: a Differential Diagnosis for Pancreatic Cystic Neoplasms and Review of the Literature

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References

  1. Mortelé KJ, Mortelé B, Silverman SG. CT features of the accessory spleen. AJR. 2004;183:1653–7.

    Article  PubMed  Google Scholar 

  2. Halpert B, Gyorkey F. Lesions observed in accessory spleens of 311 patients. Am J Clin Pathol. 1959;32:165–8.

    Article  CAS  PubMed  Google Scholar 

  3. Davidson ED, Campbell WG, Hersh T. Epidermoid splenic cyst occurring in an intrapancreatic accessory spleen. Dig Dis Sci. 1980;25:964–7. https://doi.org/10.1007/BF01308048.

    Article  CAS  PubMed  Google Scholar 

  4. Hanada M, Kimura M, Kitada M, Nakajima T, Yamada K, Yoshii M. Epidermoid cyst of accessory spleen. Acta Pathol Jpn. 1981;31:863–71.

    CAS  PubMed  Google Scholar 

  5. Nakkae Y, Hayakawa T, Kondo T, Shibata T, Kitagawa M, Sakai Y, et al. Epidermoid cyst occurring in a pancreatic accessory spleen. J Clin Gastroenterol. 1991;13:362–5. https://doi.org/10.1097/00004836-199106000-00024.

    Article  Google Scholar 

  6. Morohoshi T, Hamamoto T, Kunimura T, Yoshida E, Kanda M, Funo K, et al. Epidermoid cyst derived from an accessory spleen in the pancreas. Acta Pathol Jpn. 1991;41:916–21. https://doi.org/10.1111/j.1440-1827.1991.tb01639.x.

    Article  CAS  PubMed  Google Scholar 

  7. Tang X, Tanaka Y, Tsutsumi Y. Epithelial inclusion cysts in an intrapancreatic accessory spleen. Pathol Int. 1994;44:652–4. https://doi.org/10.1111/j.1440-1827.1994.tb01726.x.

    Article  CAS  PubMed  Google Scholar 

  8. Higaki K, Jimi A, Watanabe J, Kusaba A, Kojiro M. Epidermoid cyst of the spleen with CA19-9 or carcinoembryonic antigen productions: report of three cases. Am J Surg Pathol. 1998;22:704–8.

    Article  CAS  PubMed  Google Scholar 

  9. Furukawa H, Kosuge T, Kanai Y, Mukai K. Epidermoid cyst in an intrapancreatic accessory spleen. AJR Am J Roentgenol. 1998;171:271.

    Article  CAS  PubMed  Google Scholar 

  10. Tateyama H, Tada T, Murase T, Fujitake S, Eimoto T. Lymphoepithelial cyst and epidermoid cyst of the accessory spleen in the pancreas. Mod Pathol. 1998;11:1171–7.

    CAS  PubMed  Google Scholar 

  11. Sasou S, Nakamura S, Inomata M. Epithelial splenic cyst in an intrapancreatic accessory spleen and spleen. Pathol Int. 1999;49:1078–83. https://doi.org/10.1046/j.1440-1827.1999.00983.x.

    Article  CAS  PubMed  Google Scholar 

  12. Choi SK, Ahn SI, Hong SK, Kim SJ, Won ZH, Shin SH. A case of epidermoid cyst of the intrapancreatic accessory spleen. J Korean Med Sci. 2000;15:589–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Tsutsumi S, Kojima T, Fukai Y, Kanoh K, Shimura T, Mochiki E, et al. Epidermoid cyst of an intrapancreatic accessory spleen: a case report. Hepagastroenterology. 2000;47:1462–4.

    CAS  Google Scholar 

  14. Horibe Y, Murakami M, Yamao K, Imaeda Y, Tashiro K, Kasahara M. Epithelial inclusion cyst (epidermoid cyst) formation with epithelioid cell granuloma in an intrapancreatic accessory spleen. Pathol Int. 2001;51:50–4. https://doi.org/10.1046/j.1440-1827.2001.01155.x.

    Article  CAS  PubMed  Google Scholar 

  15. Sonomura T, Kataoka T, Chicugo T, Hirooka T, Nakamoto T, Sato M. Epidermoid cyst of an intrapancreatic accessory spleen. Abdom Imaging. 2002;27:560–2. https://doi.org/10.1007/s00261-001-0145-1.

    Article  CAS  PubMed  Google Scholar 

  16. Yokomizo H, Hifumi M, Yamane T, Hirata T, Terakura T, Murata K, et al. Epidermoid cyst of an accessory spleen at the pancreatic tail: the diagnostic value of MRI. Abdom Imaging. 2002;27:557–9. https://doi.org/10.1007/s00261-001-0055-2.

    Article  CAS  PubMed  Google Scholar 

  17. Fink AM, Kulkarni S, Cramen JA. Epidermoid cyst in a pancreatic accessory spleen mimicking an infected abdominal cyst in a child. AJR. 2002;179:206–8. https://doi.org/10.2214/ajr.179.1.1790206.

    Article  CAS  PubMed  Google Scholar 

  18. Watanabe H, Yamaguchi Y, Ohtsubo K, Mouri H, Motoo Y, Yamashita K, et al. Epidermoid cyst of the intrapancreatic accessory spleen producing CA 19-9. Dig Endosc. 2004;16:244–8. https://doi.org/10.1111/j.1443-1661.2004.00347.x.

    Article  Google Scholar 

  19. Kanazawa H, Kamiya J, Nagino M, Uesaka K, Yuasa N, Oda K, et al. Epidermoid cyst in an intrapancreatic accessory spleen. J Hepatobil Pancreas Surg. 2004;11:61–3. https://doi.org/10.1007/s00534-003-0844-9.

    Article  Google Scholar 

  20. Won JK, Lee YJ, Kang GH. Epithelial cysts in the intrapancreatic accessory spleen that clinically mimic pancreatic cystic tumor. Korean J Pathol. 2005;39:437–41.

    Google Scholar 

  21. Ru K, Kalra A, Ucci A. Epidermoid cyst of intrapancreatic accessory spleen. Dig Dis Sci. 2007;52:1229–32. https://doi.org/10.1007/s10620-006-9376-x.

    Article  PubMed  Google Scholar 

  22. Gleeson FC, Kendrick ML, Chari ST, Zhang L, Levy MJ. Epidermoid accessory splenic cyst masquerading as a pancreatic mucinous cystic neoplasm. Endoscopy. 2008;40:e141–2. https://doi.org/10.1055/s-2007-995735.

    Article  PubMed  Google Scholar 

  23. Servais EL, Sarkaria IS, Solomon GJ, Gumpeni P, Lieberman M. Giant epidermoid cyst within an intrapancreatic accessory spleen mimicking a cystic neoplasm of the pancreas: case report a review of the literature. Pancreas. 2008;36:98–100. https://doi.org/10.1097/MPA.0b013e3181359e36.

    Article  PubMed  Google Scholar 

  24. Itano O, Shiraga N, Kouta E, Iri H, Tanaka K, Suzuki F, et al. Epidermoid cyst originating from an intrapancreatic accessory spleen. J Hepatobil Pancreas Surg. 2008;15:436–9. https://doi.org/10.1007/s00534-007-1243-4.

    Article  Google Scholar 

  25. Zhang Z, Wang JW. An epithelial splenic cyst in an intrapancreatic accessory spleen. A case report. JOP. 2009;10:664–6.

    PubMed  Google Scholar 

  26. Reiss G, Sickel JZ, Tho-See K, Ramrakhini S. Intrapancreatic splenic cyst mimicking cystic neoplasm diagnosed by EUS-FNA. Gastrointest Endosc. 2009;70:557–8. https://doi.org/10.1016/j.gie.2009.04.050.

    Article  PubMed  Google Scholar 

  27. Kadota K, Kushida Y, Miyai Y, Katsuki N, Hayashi T, Mando K, et al. Epidermoid cyst in an intrapancreatic accessory spleen: three case reports and review of the literature. Pathol Oncol Res. 2010;16:435–42. https://doi.org/10.1007/s12253-009-9229-y.

    Article  PubMed  Google Scholar 

  28. Itano O, Chiba N, Wada T, Yuasa Y, Sato T, Ishikawa H, et al. Laparoscopic resection of an epidermoid cyst originating from intrapancreatic accessory spleen: report of a case. Surg Today. 2010;40:72–5. https://doi.org/10.1007/s00595-009-4006-9.

    Article  PubMed  Google Scholar 

  29. Horn AJ, Lele SM. Epidermoid cyst occurring within an intrapancreatic accessory spleen. A case report and review of the literature. J Pancreas. 2011;12:279–82.

    Google Scholar 

  30. Urakami A, Yoshida K, Hirabayashi Y, Kubota H, Yamshita K, Hirai T, et al. Laparoscopic-assisted spleen preserving pancreatic resection for epidermoid cyst in an intrapancreatic accessory spleen. Asian J End Surg. 2011;4:185–8. https://doi.org/10.1111/j.1758-5910.2011.00102.x.

    Article  CAS  Google Scholar 

  31. Khashab MA, Canto IM, Singh VK, Hruban RH, Makary MA, Giday S. Endosonographic and elastographic features of a rare epidermoid cyst of an intrapancreatic accessory spleen. Endoscopy. 2011;43:E193–4. https://doi.org/10.1055/s-0030-1256272.

    Article  PubMed  Google Scholar 

  32. Yamanishi H, Kumagi T, Yokota T, Koizumi M, Azemoto N, Watanabe J, et al. Epithelial cyst arising in an intrapancreatic accessory spleen: a diagnostic dilemma. Intern Med. 2011;50:1947–52. https://doi.org/10.2169/internalmedicine.50.5340.

    Article  PubMed  Google Scholar 

  33. Iwasaki Y, Tagaya N, Nakagawa A, Kita J, Imura J, Fujimori T, et al. Laparoscopic resection of epidermoid cyst arising from an intrapancreatic accessory spleen: a case report with review of the literature. Surg Laparosc Endosc Percutan Tech. 2011;21:e275–9. https://doi.org/10.1097/SLE.0b013e31822dd14a.

    Article  PubMed  Google Scholar 

  34. Nikolas P, Metesh A, Raida A, Devinedr B, Long J. Epithelial inclusion cyst arising within an intra-pancreatic splenunculus. Int J Surg Case Rep. 2012;3(3):118–20. https://doi.org/10.1016/j.ijscr.2011.12.005.

    Article  Google Scholar 

  35. Harris CA, Chaudry MA, Menzies A, Conn PC. Laparoscopic resection of an epidermoid cyst within an intrapancreatic accessory spleen: a case report and review of the literature. Surg Laparosc Endosc Percutan Tech. 2012;22:e246–9. https://doi.org/10.1097/SLE.0b013e31825b3761.

    Article  PubMed  Google Scholar 

  36. Hong R, Choi N, Sun K, Lim S, Han Y. Epidermoid cyst arising from an intrapancreatic accessory spleen: a case report and review of the literature. Oncol Lett. 2013;5(2):469–72. https://doi.org/10.3892/ol.2012.1061.

    Article  PubMed  Google Scholar 

  37. Lee CL, Yang D, Yong JJ, Chen J, Fu DL. Epidermal cyst of intrapancreatic accessory spleen. A case report and literature review. World J Surg Proc. 2013;3(3):54–9.

    Article  Google Scholar 

  38. Zavras N, Machairas N, Foukas P, Lazaris A, Patapis P, Machairas A. Epidermoid cyst of an intrapancreatic accessory spleen: a case report and literature review. World J Surg Oncol. 2014;12:92. https://doi.org/10.1186/1477-7819-12-92.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Kwak MK, Lee NK, Kim S, Han GJ, Seo HI, do Park Y, et al. A case of epidermoid cyst in an intrapancreatic accessory spleen mimicking pancreas neoplasms: MRI with DWI. Clin Imaging. 2016;40(1):164–6. https://doi.org/10.1016/j.clinimag.2015.09.004.

    Article  PubMed  Google Scholar 

  40. Bhutiani N, Egger ME, Doughtie CA, Burkadt ES, Scoggins CR, Martin RC 2nd, et al. Intrapancreatic accessory spleen (IPAS): a single-institution experience and review of literature. Am J Surg. 2017;213(4):816–20. https://doi.org/10.1016/j.amjsurg.2016.11.030.

    Article  PubMed  Google Scholar 

  41. Van Dijck WPM, Groot VP, Brosens LAA, Hagendoorn J, Rinkes IHMB, Van Leeuwen MS, et al. Rare case of an epithelial cyst in an intrapancreatic accessory spleen treated by robot-assisted spleen preserving distal Pancreatectomy. Case Rep Gastrointest Med. 2016;9475897 https://doi.org/10.1155/2016/9475897.

  42. Kim SH, Lee JM, Han JK, Lee JY, Kim KW, Cho KC, et al. Intrapancreatic accessory spleen: findings on MR imaging, CT, US and scintigraphy, and the pathologic analysis. Korean J Radiol. 2008;9(2):162–74.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Spencer LA, Spizarny DL, Williams TR. Imaging features of intrapancreatic accessory spleen. Br J Radiol. 2010;83:668–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. SH O, Lee JK, Lee KT, Lee KH, Woo YS, Noh DH. The combination of cyst fluid carcinoembryonic antigen, cytology and viscosity increases the diagnostic accuracy of mucinous pancreatic cysts. Gut Liver. 2017;11(2):283–89.

  45. Brugge WR, Lewandrowski K, Lee-Lewandrowski E, Centeno BA, Szydio T, Regan S, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology. 2004;126:1330–6.

    Article  PubMed  Google Scholar 

  46. Cizginer S, Turner BG, Bilge AR, Karaca C, Pitman MB, Brugge WR. Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts. Pancreas. 2011;40:1024–8.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of General Surgery, Singapore General Hospital, Bukit Merah, Singapore

    Hiang Jin Tan & Wei Li Neo

  2. Department of Hepato-pancreato-biliary and Transplant Surgery, Singapore General Hospital, Bukit Merah, Singapore

    Ser Yee Lee, Brian Kim Poh Goh & Juinn Huar Kam

  3. Duke-NUS Medical School, Singapore, Singapore

    Ser Yee Lee, Brian Kim Poh Goh & Juinn Huar Kam

Authors
  1. Hiang Jin Tan
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  2. Wei Li Neo
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Correspondence to Ser Yee Lee.

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Tan, H.J., Neo, W.L., Lee, S.Y. et al. Epidermal Inclusion Cyst in an Intra-pancreatic Accessory Spleen: a Differential Diagnosis for Pancreatic Cystic Neoplasms and Review of the Literature. J Gastrointest Canc 50, 308–314 (2019). https://doi.org/10.1007/s12029-017-0002-2

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