Abstract
Introduction
MicroRNAs are non-coding RNAs that regulate the gene expression at post-transcriptional level. This futuristic study characterized the contribution of miR-1287 to the colorectal cancer (CRC) tumorigenesis.
Methods
The real-time reverse transcription–polymerase chain reaction was used to examine miR-1287 expression levels, prospectively in 40 pairs of CRC tissue samples and adjacent noncancerous tissues (>2 cm from cancer tissue).
Results
No significant relationship was found between miR-1287 expression levels and clinicopathological features. Showing significant changes overall, MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples. A receiver operating characteristic (ROC) curve also showed ROC area (AROC) of 34 % with 1.0 and 0.02 sensitivity and specificity, respectively. Expression of miR-1287, with a value of 0.34, P value = 1.98, and P > 0.05, revealed that this microRNA has a low sensitivity and specificity to be regarded as a tumor marker.
Conclusions
With regard to recent increased rate of CRC in the world, the present study may be a contribution, though very small, in the diagnosis and consequently in the treatment of CRC patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chalya PL et al. Clinicopathological patterns and challenges of management of colorectal cancer in a resource-limited setting: a Tanzanian experience. World J Surg Oncol. 2013;11(1):88–97.
Shivapurkar N et al. Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs. PLoS One. 2014;9(1):e84686.
Center MM et al. Worldwide variations in colorectal cancer. CA Cancer J Clin. 2009;59(6):366–78.
Moghimi-Dehkordi B, Safaee A, Zali MR. Prognostic factors in 1,138 Iranian colorectal cancer patients. Int J Colorectal Dis. 2008;23(7):683–8.
Somi MH et al. Gastrointestinal cancer incidence in East Azerbaijan, Iran: update on 5 year incidence and trends. Asian Pac J Cancer Prev. 2014;15(9):3945–9.
Ferlay J et al. GLOBOCAN 2012 v1. 0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. Lyon: International Agency for Research on Cancer; 2013. globocan. iarc. fr, 2015.
Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology. 2010;138(6):2029–2043.e10.
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;11(2):281–97.
Bentwich I et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet. 2005;37(7):766–70.
Pritchard CC, Cheng HH, Tewari M. MicroRNA profiling: approaches and considerations. Nat Rev Genet. 2012;13(5):358–69.
Watahiki A et al. MicroRNAs associated with metastatic prostate cancer. PLoS One. 2011;6(9), e24950.
Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. 2008;26(17):2828–38.
Hogan NM, Joyce MR, Kerin MJ. MicroRNA expression in colorectal cancer. Cancer Biomark. 2012;11(6):239–43.
Cai C et al. MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS One. 2012;7(1):e29750.
Baranwal S, Alahari SK. miRNA control of tumor cell invasion and metastasis. Int J Cancer. 2010;126(6):1283–90.
Wang Y et al. Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. Cancer Genet. 2013;206(9-10):340–6.
Wu G et al. AKT/ERK activation is associated with gastric cancer cell resistance to paclitaxel. Int J Clin Exp Pathol. 2014;7(4):1449.
Schetter AJ, Okayama H, Harris CC. The role of microRNAs in colorectal cancer. Cancer journal (Sudbury, Mass). 2012;18(3):244.
Xi Y et al. Prognostic values of microRNAs in colorectal cancer. Biomark Insights. 2006;2:113–21.
Banno K et al. MicroRNA in cervical cancer: oncomiRs and tumor suppressor miRs in diagnosis and treatment. ScientificWorldJournal. 2014;2014:178075.
Wang W et al. MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response. Haematologica. 2012;97(4):586–94.
Guo L et al. Genome-wide screen for aberrantly expressed miRNAs reveals miRNA profile signature in breast cancer. Mol Biol Rep. 2013;40(3):2175–86.
Shen J et al. Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer. Carcinogenesis. 2012;33(3):604–12.
Acknowledgments
The researchers thank the staff, nurses, and patients of the Endoscopy Department of Tabriz Imam Reza Hospital for their helpful collaboration. No funding had been received.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
All study participants were born in East Azerbaijan, Iran, and none of them had taken chemotherapy or radiotherapy and adjuvant therapy. The study was accepted by the Research Ethics Committee of Imam Reza Hospital in conformity with institutional protocol, and informed consents were obtained from all patients.
Conflict of Interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Fateh, A., Feizi, M.A.H., Safaralizadeh, R. et al. Diagnostic and Prognostic Value of miR-1287 in Colorectal Cancer. J Gastrointest Canc 47, 399–403 (2016). https://doi.org/10.1007/s12029-016-9833-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12029-016-9833-5