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Tuberous Sclerosis Complex with Multiple Gastrointestinal Manifestations. Case Report and Literature Review

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References

  1. Curatolo P, Bombardieri R. Tuberous sclerosis. Handb Clin Neurol. 2008;87:129–51.

    Article  PubMed  Google Scholar 

  2. Hallett L, Foster T, Liu Z, Blieden M, Valentim J. Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: systematic review. Curr Med Res Opin. 2011;27(8):1571–83.

    Article  PubMed  Google Scholar 

  3. Al-Saleem T, Wessner LL, Scheithauer BW, Patterson K, Roach ES, Dreyer SJ, et al. Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer. 1998;83(10):2208–16.

    Article  CAS  PubMed  Google Scholar 

  4. Narod SA, Stiller C, Lenoir GM. An estimate of the heritable fraction of childhood cancer. Br J Cancer. 1991;63(6):993–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Devroede G, Lemieux B, Massé S, Lamarche J, Herman PS. Colonic hamartomas in tuberous sclerosis. Gastroenterology. 1988;94(1):182–8.

    Article  CAS  PubMed  Google Scholar 

  6. Gould SR. Hamartomatous rectal polyps are common in tuberous sclerosis. Ann N Y Acad Sci. 1991;615:71–80.

    Article  CAS  PubMed  Google Scholar 

  7. Hizawa K, Iida M, Matsumoto T, Tominaga M, Hirota C, Yao T, et al. Gastrointestinal involvement in tuberous sclerosis. Two case reports. J Clin Gastroenterol. 1994;19(1):46–9.

    Article  CAS  PubMed  Google Scholar 

  8. Kim BK, Kim YI, Kim WH. Hamartomatous gastric polyposis in a patient with tuberous sclerosis. J Korean Med Sci. 2000;15(4):467–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Byard RW, Phillips GE, Dardick I, Robertson E, Carter RF, Bourne AJ. Two unusual tumours of the gastrointestinal tract in a patient with tuberous sclerosis. J Paediatr Child Health. 1991;27(2):116–9.

    Article  CAS  PubMed  Google Scholar 

  10. Goh SG, Ho JM, Chuah KL, Tan PH, Poh WT, Riddell RH. Leiomyomatosis-like lymphangioleiomyomatosis of the colon in a female with tuberous sclerosis. Mod Pathol. 2001;14(11):1141–6.

    Article  CAS  PubMed  Google Scholar 

  11. Moulis H, Garsten JJ, Marano AR, Elser JM. Tuberous sclerosis complex: review of the gastrointestinal manifestations and report of an unusual case. Am J Gastroenterol. 1992;87(7):914–8.

    CAS  PubMed  Google Scholar 

  12. Digoy GP, Tibayan F, Young H, Edelstein P. Adenocarcinoma of the rectum with associated colorectal adenomatous polyps in tuberous sclerosis: a case report. J Pediatr Surg. 2000;35(3):526–7.

    Article  CAS  PubMed  Google Scholar 

  13. Ahmed S, Burney I, Sawhney S, Al-Moundhri MS. Gastric Adenocarcinoma in Association with Tuberous Sclerosis: Case report. Sultan Qaboos Univ Med J. 2009;9(1):75–8. Epub 2009 Mar 16.

    PubMed  PubMed Central  Google Scholar 

  14. Doyle LA, Hornick JL, Fletcher CD. PEComa of the gastrointestinal tract: clinicopathologic study of 35 cases with evaluation of prognosticparameters. Am J Surg Pathol. 2013;37(12):1769–82.

    Article  PubMed  Google Scholar 

  15. Black ME, Hedgire SS, Camposano S, Paul E, Harisinghani M, Thiele EA. Hepatic manifestations of tuberous sclerosis complex: a genotypic and phenotypic analysis. Clin Genet. 2012;82(6):552–7.

    Article  CAS  PubMed  Google Scholar 

  16. Arva NC, Pappas JG, Bhatla T, Raetz EA, Macari M, Ginsburg HB, et al. Well differentiated pancreatic neuroendocrine carcinoma in tuberous sclerosis—case report and review of theliterature. Am J Surg Pathol. 2012;36(1):149–53.

    Article  PubMed  Google Scholar 

  17. Bombardieri R, Moavero R, Roberto D, Cerminara C, Curatolo P. Pancreatic neuroendocrine tumor in a child with a tuberous sclerosis complex 2 (TSC2) mutation. Endocr Pract. 2013;19(5):e124–8.

    Article  PubMed  Google Scholar 

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Author Contributions

Yaseen Alastal and Muhammad Ali Khan conducted the literature review; Soukayna Rkaine wrote the case vignette; Thomas C Sodeman and A. Nawras supervised the article process; and Tariq Hammad is the article guarantor.

A case abstract was presented as poster in American College of Gastroenterology Abstracts-2010 meeting, under the name of “Unusual Case of Obscure Overt Gastrointestinal Bleeding Diagnosed with Spirus Enteroscopy in Patient with Tuberous Sclerosis”.

Conflict of Interest

The authors have no financial disclosures and no conflicts of interest to report.

Informed Consent

Consent was obtained from the patient per our institution policy.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH, 43614, USA

    Tariq A. Hammad, Yaseen Alastal, Muhammad Ali Khan & Soukayna Rkaine

  2. Department of Gastroenerology and Hepatology, University of Toledo Medical Center, Toledo, OH, USA

    Thomas C. Sodeman & Ali Nawras

Authors
  1. Tariq A. Hammad
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  2. Yaseen Alastal
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  3. Muhammad Ali Khan
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  4. Soukayna Rkaine
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  5. Thomas C. Sodeman
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  6. Ali Nawras
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Corresponding author

Correspondence to Tariq A. Hammad.

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Hammad, T.A., Alastal, Y., Khan, M.A. et al. Tuberous Sclerosis Complex with Multiple Gastrointestinal Manifestations. Case Report and Literature Review. J Gastrointest Canc 47, 442–445 (2016). https://doi.org/10.1007/s12029-015-9762-8

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  • DOI: https://doi.org/10.1007/s12029-015-9762-8

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