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Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

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Abstract

Purpose

Developmental pathways such as Wnt and Notch are involved in different cellular functions from the cell cycle regulation to self-renewal. Therefore, aberrations in these pathways may cause tumorigenesis. Msi1 has a critical regulatory role for the Wnt and Notch pathways. In the present study, we have assessed the probable correlation between the Msi1 and MAML1 in esophageal squamous cell carcinoma (ESCC) progression and metastasis.

Methods

Levels of Msi1 and MAML1 mRNA expression in 51 ESCC patients were compared to the normal tissues using real-time polymerase chain reaction (PCR).

Results

Nine out of 51 (17.6 %) cases had Msi1/MAML1 overexpression, and there was a significant correlation between such overexpressed cases and tumor location (p = 0.013).

Conclusions

We showed that there is not any direct correlation and feedback between the Msi1 and MAML1 in ESCC patients.

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Acknowledgment

This work was supported by a grant from the Vice Chancellor for Research at Mashhad University of Medical Sciences, and was part of a Ph. D. student’s dissertation, no. 921202.

Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Meysam Moghbeli & Mohammad Reza Abbaszadegan

  2. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

    Mohammad Mahdi Forghanifard

  3. Cardiothoracic Surgery and Transplant Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Ali Sadrizadeh

  4. Department of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Hooman Mosannen Mozaffari

  5. Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran

    Ebrahim Golmakani

  6. Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Reza Abbaszadegan

Authors
  1. Meysam Moghbeli
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  2. Mohammad Mahdi Forghanifard
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  3. Ali Sadrizadeh
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  4. Hooman Mosannen Mozaffari
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  5. Ebrahim Golmakani
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  6. Mohammad Reza Abbaszadegan
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Corresponding author

Correspondence to Mohammad Reza Abbaszadegan.

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Moghbeli, M., Forghanifard, M.M., Sadrizadeh, A. et al. Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma. J Gastrointest Canc 46, 365–369 (2015). https://doi.org/10.1007/s12029-015-9753-9

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  • DOI: https://doi.org/10.1007/s12029-015-9753-9

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