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Well-Differentiated Neuroendocrine Tumour of the Extrahepatic Bile Duct: a Case Report with Review of Literature

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Fig. 1
Fig. 2



5-Hydroxyindoleacetic acid


Common bile duct


Chromogranin A


Computed tomography


Endoscopic retrograde cholangiopancreatography


Endoscopic ultrasonography


Fine-needle aspiration cytology


Magnetic resonance imaging


Neural cell adhesion molecule


Neuroendocrine tumour


Neuron-specific enolase


  1. Maggard MA, O’Connell JB, Ko CY. Updated population-based review of carcinoid tumors. Ann Surg. 2004;240(1):117–22.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Chamberlain RS, Blumgart LH. Carcinoid tumors of the extrahepatic bile duct. A rare cause of malignant biliary obstruction. Cancer. 1999;86(10):1959–65.

    Article  CAS  PubMed  Google Scholar 

  3. Govil H, Reddy V, Kluskens L, Treaba D, Massarani-Wafai R, Selvaggi S, et al. Brush cytology of the biliary tract: retrospective study of 278 cases with histopathologic correlation. Diagn Cytopathol. 2002;26(5):273–7. doi:10.1002/dc.10098.

    Article  PubMed  Google Scholar 

  4. Thompson GB, van Heerden JA, Martin Jr JK, Schutt AJ, Ilstrup DM, Carney JA. Carcinoid tumors of the gastrointestinal tract: presentation, management, and prognosis. Surgery. 1985;98(6):1054–63.

    CAS  PubMed  Google Scholar 

  5. Davies AJ. Carcinoid Tumours (Argentaffinomata): Hunterian Lecture delivered at the Royal College of Surgeons of England on 3rd March 1959. Ann R Coll Surg Engl. 1959;25(5):277–97.

    PubMed Central  CAS  PubMed  Google Scholar 

  6. Pilz E. On carcinoid of the bile duct. Zentralblatt Fur Chirurgie. 1961;86:1588–90.

    CAS  PubMed  Google Scholar 

  7. Bhandarwar AH, Shaikh TA, Borisa AD, Palep JH, Patil AS, Manke AA. Primary neuroendocrine tumor of the left hepatic duct: a case report with review of the literature. Case Rep Surg. 2012;2012:786432. doi:10.1155/2012/786432.

    PubMed Central  PubMed  Google Scholar 

  8. Capella C, Solcia E, Sobin L, Arnold R. Endocrine tumors of the gallbladder and extrahepatic bile ducts. WHO Classification of Tumors. In: Hamilton R, Aaltonen LA, editors. Pathology and genetics of tumors of the digestive system. Lyon: IARC Press; 2000. p. 214–66.

    Google Scholar 

  9. Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 2010;39(6):707–12. doi:10.1097/MPA.0b013e3181ec124e.

    Article  PubMed  Google Scholar 

  10. Noronha YS, Raza AS. Well-differentiated neuroendocrine (carcinoid) tumors of the extrahepatic biliary ducts. Arch Pathol Lab Med. 2010;134(7):1075–9. doi:10.1043/2008-0764-RS.1.

    PubMed  Google Scholar 

  11. Albores-Saavedra J, Batich K, Hossain S, Henson DE, Schwartz AM. Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the surveillance, epidemiology, and end results program. Ann Diagn Pathol. 2009;13(6):378–83. doi:10.1016/j.anndiagpath.2009.08.002.

    Article  PubMed  Google Scholar 

  12. Jethava A, Muralidharan V, Mesologites T, Stoica-Mustafa E, Dasanu CA. An unusual presentation of a carcinoid tumor of the common bile duct. JOP: J Pancreas. 2013;14(1):85–7. doi:10.6092/1590-8577/1232.

    Google Scholar 

  13. Maitra A, Krueger JE, Tascilar M, Offerhaus GJ, Angeles-Angeles A, Klimstra DS, et al. Carcinoid tumors of the extrahepatic bile ducts: a study of seven cases. Am J Surg Pathol. 2000;24(11):1501–10.

    Article  CAS  PubMed  Google Scholar 

  14. Stavridi F, Chong H, Chan S, Goldsmith C, Reddy M, Glees J, et al. Neuroendocrine tumour of the cystic duct: a case report and literature review. J Gastrointest Cancer. 2007;38(1):32–3.

    Article  PubMed  Google Scholar 

  15. Ioannidis O, Cheva A, Paraskevas G, Chatzopoulos S, Kotronis A, Papadimitriou N, et al. Neuroendocrine tumor of the cystic duct. Acta Gastro-Enterologica Belgica. 2012;75(3):357–60.

    CAS  PubMed  Google Scholar 

  16. Bajetta E, Ferrari L, Martinetti A, Celio L, Procopio G, Artale S, et al. Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. Cancer. 1999;86(5):858–65.

    Article  CAS  PubMed  Google Scholar 

  17. Prestifilippo A, Blanco G, Vitale MP, Giuffrida D (2012) Chromogranin A and neuroendocrine tumors. InTech.

  18. Haug AR, Cindea-Drimus R, Auernhammer CJ, Reincke M, Wangler B, Uebleis C, et al. The role of 68Ga-DOTATATE PET/CT in suspected neuroendocrine tumors. J Nucl Med Off Publ Soc Nucl Med. 2012;53(11):1686–92. doi:10.2967/jnumed.111.101675.

    CAS  Google Scholar 

  19. El Rassi ZS, Mohsine RM, Berger F, Thierry P, Partensky CC. Endocrine tumors of the extrahepatic bile ducts. Pathological and clinical aspects, surgical management and outcome. Hepato-Gastroenterology. 2004;51(59):1295–300.

    PubMed  Google Scholar 

  20. Hong N, Kim HJ, Byun JH, Kim SY, Kim KW, Kim JH, et al. Neuroendocrine neoplasms of the extrahepatic bile duct: radiologic and clinical characteristics. Abdom Imaging. 2015;40(1):181–91. doi:10.1007/s00261-014-0191-0.

    Article  PubMed  Google Scholar 

  21. Alexandraki KI, Kaltsas G. Gastroenteropancreatic neuroendocrine tumors: new insights in the diagnosis and therapy. Endocrine. 2012;41(1):40–52. doi:10.1007/s12020-011-9562-2.

    Article  CAS  PubMed  Google Scholar 

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Safwan, M., Vij, M., Govil, S. et al. Well-Differentiated Neuroendocrine Tumour of the Extrahepatic Bile Duct: a Case Report with Review of Literature. J Gastrointest Canc 47, 93–99 (2016).

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