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Ghrelin- and Serotonin-Producing Gastric Carcinoid

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Abstract

We report the case of a 57-year-old woman with gastric carcinoid. The tumor was surgically removed and immunohistochemical investigation demonstrated a rare combination: ghrelin and serotonin in the cytoplasm of the tumor cells. The functional significance of simultaneous production of ghrelin and serotonin is not clear. It may be that an autocrine/paracrine interaction exists between these two different hormones.

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Acknowledgment

Authors are grateful to the Jarislowsky and Lloyd Carr-Harris Foundations for their generous support. We are also very much indebted to Ms. Corinne Holubowich for the literature search and to Mr. Mark Moreland and Ms. Vidya Beharri for their technical assistance.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Division of Pathology, St. Michael’s Hospital, University of Toronto, Toronto, ON, M5B1W8, Canada

    Eleanor Latta, Fabio Rotondo, Eva Horvath & Kalman Kovacs

  2. Department of Medicine, Division of Endocrinology and Metabolism, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Lawrence A. Leiter

Authors
  1. Eleanor Latta
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  2. Fabio Rotondo
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  3. Lawrence A. Leiter
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  4. Eva Horvath
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  5. Kalman Kovacs
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Corresponding author

Correspondence to Fabio Rotondo.

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Latta, E., Rotondo, F., Leiter, L.A. et al. Ghrelin- and Serotonin-Producing Gastric Carcinoid. J Gastrointest Canc 43, 319–323 (2012). https://doi.org/10.1007/s12029-011-9275-z

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  • DOI: https://doi.org/10.1007/s12029-011-9275-z

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