Skip to main content


Log in

Nested Stromal Epithelial Tumor of the Liver—Liver Transplantation and Follow-Up

  • Case Report
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript



The nested stromal epithelial tumor (NSET) of the liver is a rare tumor entity which is being reported in young girls.

Case Report

In our 16-year-old female patient, we have performed a liver transplantation (LTX) for a non-metastasizing non-resectable liver tumor. The patient was tumor free in the follow-up. At 28 months postoperatively, we detected lung metastases in the F18-FDG-PET/CT. The patient died 37 months after LTX from progressive pulmonary metastases.


LTX should not have been generally recommended for NSET. Further statements about the value of LTX for NSET will be possible only after evaluation of the course of the disease in a larger number of transplanted patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3



Nested stromal epithelial tumor


Liver transplantation


Computed tomography


Magnetic resonance imaging


Positron emission tomography


  1. Emre S, McKenna GJ. Liver tumors in children. Pediatr Transplant. 2004;8:632–8.

    Article  PubMed  Google Scholar 

  2. Perilongo G, Shafford EA. Liver tumours. Eur J Cancer. 1999;35:953–8. discussion 958-959.

    Article  PubMed  CAS  Google Scholar 

  3. Weinberg AG, Finegold MJ. Primary hepatic tumors of childhood. Hum Pathol. 1983;14:512–37.

    Article  PubMed  CAS  Google Scholar 

  4. Grazi GL, Vetrone G, d’Errico A, et al. Nested stromal-epithelial tumor (NSET) of the liver: a case report of an extremely rare tumor. Pathol Res Pract. 2010;206:282–6.

    Article  PubMed  Google Scholar 

  5. Makhlouf HR, Abdul-Al HM, Wang G, Goodman ZD. Calcifying nested stromal-epithelial tumors of the liver: a clinicopathologic, immunohistochemical, and molecular genetic study of 9 cases with a long-term follow-up. Am J Surg Pathol. 2009;33:976–83.

    Article  PubMed  Google Scholar 

  6. Meir K, Maly A, Doviner V, et al. Nested (ossifying) stromal epithelial tumor of the liver: case report. Pediatr Dev Pathol. 2009;12:233–6.

    Article  PubMed  Google Scholar 

  7. Hill DA, Swanson PE, Anderson K, et al. Desmoplastic nested spindle cell tumor of liver: report of four cases of a proposed new entity. Am J Surg Pathol. 2005;29:1–9.

    Article  PubMed  Google Scholar 

  8. Heywood G, Burgart LJ, Nagorney DM. Ossifying malignant mixed epithelial and stromal tumor of the liver: a case report of a previously undescribed tumor. Cancer. 2002;94:1018–22.

    Article  PubMed  Google Scholar 

  9. Brodsky SV, Sandoval C, Sharma N, et al. Recurrent nested stromal epithelial tumor of the liver with extrahepatic metastasis: case report and review of literature. Pediatr Dev Pathol. 2008;11:469–73.

    Article  PubMed  Google Scholar 

  10. Oviedo Ramirez MI, Bas Bernal A, Ortiz Ruiz E, et al. Desmoplastic nested spindle cell tumor of the liver in an adult. Ann Diagn Pathol. 2010;14:44–9.

    Article  PubMed  Google Scholar 

  11. Newman KD. Hepatic tumors in children. Semin Pediatr Surg. 1997;6:38–41.

    PubMed  CAS  Google Scholar 

  12. Stocker JT. An approach to handling pediatric liver tumors. Am J Clin Pathol. 1998;109:S67–72.

    PubMed  CAS  Google Scholar 

  13. Reyes JD, Carr B, Dvorchik I, et al. Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular cancer in childhood and adolescence. J Pediatr. 2000;136:795–804.

    Article  PubMed  CAS  Google Scholar 

  14. Achilleos OA, Buist LJ, Kelly DA, et al. Unresectable hepatic tumors in childhood and the role of liver transplantation. J Pediatr Surg. 1996;31:1563–7.

    Article  PubMed  CAS  Google Scholar 

  15. Avila LF, Encinas JL, Leal N, et al. Liver transplatation for malignant tumors in children. Cir Pediátr. 2007;20:189–93.

    PubMed  CAS  Google Scholar 

  16. Jayaram A, Finegold MJ, Parham DM, Jasty R. Successful management of rhabdoid tumor of the liver. J Pediatr Hematol Oncol. 2007;29:406–8.

    Article  PubMed  CAS  Google Scholar 

  17. Stringer MD. The role of liver transplantation in the management of paediatric liver tumours. Ann R Coll Surg Engl. 2007;89:12–21.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Merten Hommann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hommann, M., Kaemmerer, D., Daffner, W. et al. Nested Stromal Epithelial Tumor of the Liver—Liver Transplantation and Follow-Up. J Gastrointest Canc 42, 292–295 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI: