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Assessment of Qualitative Changes of Acid Mucins Among Sudanese Colorectal Carcinoma Patients

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Abstract

Purpose

This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon.

Methods

A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method.

Results

Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls.

Conclusions

CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.

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Authors and Affiliations

  1. Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, P.O. Box 11081, Khartoum, 11111, Sudan

    Yosef Mohamed-Azzam Zakout & Yousra Altegani Ezeldeen

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  1. Yosef Mohamed-Azzam Zakout
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  2. Yousra Altegani Ezeldeen
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Correspondence to Yosef Mohamed-Azzam Zakout.

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Zakout, Y.MA., Ezeldeen, Y.A. Assessment of Qualitative Changes of Acid Mucins Among Sudanese Colorectal Carcinoma Patients. J Gastrointest Canc 43, 205–208 (2012). https://doi.org/10.1007/s12029-010-9246-9

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  • DOI: https://doi.org/10.1007/s12029-010-9246-9

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