Abstract
We report herein a unique case of an adenosquamous carcinoma (ASC) of the pancreas and a synchronous gastrointestinal stromal tumor (GIST) of stomach in a 75-year-old Caucasian male. He presented with painless jaundice and generalized pruritus and was found to have a pancreatic head mass. Whipple's procedure was performed and yielded the above diagnoses. Ductal pancreatic adenocarcinoma, not a much rarer and more aggressive ASC subtype, has previously been shown to co-exist with GIST in some surgical series. In addition, the incidentally discovered GIST in our patient involved the stomach and not the small intestine, which is the predominant GIST location when concurrently diagnosed with other GI tumors. At the time of this publication, our patient, who received adjuvant chemoradiotherapy, remains disease-free 14 months after the abdominal surgery.
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References
Agaimy A, Wuensch PH. Gastrointestinal stromal tumours in patients with other-type cancer: a mere coincidence or an etiological association? A study of 97 GIST cases. Z Gastroenterol. 2005;43(9):1025–30.
Biasco G, Velo D, Angriman I, et al. Gastrointestinal stromal tumors: report of an audit and review of the literature. Eur J Cancer Prev. 2009;18(2):106–16.
Kövér E, Faluhelyi Z, Bogner B, et al. Dual tumours in the GI tract: synchronous and metachronous stromal (GIST) and epithelial/neuroendocrine neoplasms. Magy Onkol. 2004;48(4):315–21.
Wronski M, Ziarkiewicz-Wroblewska B, Gornicka B, et al. Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms. World J Gastroenterol. 2006;12(33):5360–2.
Liszka Ł, Zielińska-Pajak E, Pajak J, et al. Coexistence of gastrointestinal stromal tumors with other neoplasms. J Gastroenterol. 2007;42(8):641–9.
Liu YJ, Yang Z, Hao LS, et al. Synchronous incidental gastrointestinal stromal and epithelial malignant tumors. World J Gastroenterol. 2009;15(16):2027–31.
Kardon DE, Thompson LD, Przygodzki RM, et al. Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases. Mod Pathol. 2001;14(5):443–51.
Rabin I, Chikman B, Lavy R, et al. Gastrointestinal stromal tumors: a 19 year experience. Isr Med Assoc J. 2009;11(2):98–102.
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We certify that we do not have any affiliation with or financial involvement in any organization or entity with a direct financial interest in the subject matter or materials discussed in the manuscript (e.g., employment, consultancies, stock ownership, honoraria, or expert testimony). We do not have any commercial or proprietary interest in any drug, device, or equipment mentioned in the article below. No financial support was used for this work. No previously published figures or tables were used in this paper. We certify sufficient participation of each author in the conception, design, analysis, interpretation, writing, revising, and approval of the manuscript.—The authors
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Dasanu, C.A., Mesologites, T. & Trikudanathan, G. Synchronous Tumors: Adenosquamous Carcinoma of Pancreas and GIST of Stomach. J Gastrointest Canc 42, 186–189 (2011). https://doi.org/10.1007/s12029-010-9187-3
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DOI: https://doi.org/10.1007/s12029-010-9187-3