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Non-Hodgkin Lymphomas of the Oral Cavity in AIDS Patients in a Reference Hospital of Infectious Diseases in Argentina: Report of Eleven Cases and Review of the Literature

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Abstract

Introduction

Extranodal non-Hodgkin lymphoma (NHL) were commonly described in AIDS patients and are related with an atypical morphology and aggressive clinical course.

Materials and Methods

In this single institutional study we evaluated the epidemiological, clinical, immunological, virological, histopathological and the outcome of eleven HIV/AIDS patients with oral cavity lymphomas (OCL).

Results

Nine were males and seven intravenous drug abusers. The median of age was 33 years and the median of CD4 T cell counts at the time of diagnosis was 97 cell/µL. The majority of tumors presented as large and ulcerated masses involving the gingiva, the palate and the jaw. Six of these tumors were diffuse large B-cell lymphomas (DLBCL); three were Burkitt’s lymphomas and the final case was a plasmablastic lymphoma. An association with Epstein-Barr virus (EBV) was found in three of the ten tested cases by in situ hybridization (EBER 1 and 2 probes) and immunohistochemistry (LMP-1). Human herpes virus-8 (HHV-8) was detected by polymerase chain reaction (PCR) in only one neoplasm. Six patients died without specific treatment; four received chemotherapy and highly active antiretroviral therapy (HAART) and three of them presented a prolonged survival.

Discussion

Combination of HAART and chemotherapy should modify the poor prognosis of AIDS patients with OCL.

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Authors and Affiliations

  1. Division “B”, Infectious Diseases F. J. Muñiz Hospital, Puán 381 2º C 1406 CQG, Buenos Aires, Argentina

    Marcelo Corti, Maria Florencia Villafañe, Ruben Solari, Luis De Carolis, Diana Cangelosi, Jose Santoro & Ricardo Schtirbu

  2. Juan A. Fernández Hospital, Buenos Aires, Argentina

    Daniel Lewi

  3. Ramos Mejía Hospital, Buenos Aires, Argentina

    Alicia Bistmans

  4. National Academy of Medicine, Buenos Aires, Argentina

    Marina Narbaitz & Patricia Baré

Authors
  1. Marcelo Corti
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  2. Maria Florencia Villafañe
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  3. Ruben Solari
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  4. Luis De Carolis
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  5. Diana Cangelosi
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  6. Jose Santoro
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  7. Ricardo Schtirbu
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  8. Daniel Lewi
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  9. Alicia Bistmans
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  10. Marina Narbaitz
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  11. Patricia Baré
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Corresponding author

Correspondence to Marcelo Corti.

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Corti, M., Villafañe, M.F., Solari, R. et al. Non-Hodgkin Lymphomas of the Oral Cavity in AIDS Patients in a Reference Hospital of Infectious Diseases in Argentina: Report of Eleven Cases and Review of the Literature. J Gastrointest Canc 42, 143–148 (2011). https://doi.org/10.1007/s12029-010-9173-9

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  • DOI: https://doi.org/10.1007/s12029-010-9173-9

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