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Clubbing and Hypertrophic Osteoarthropathy in Two Patients Taking Long-Term Bevacizumab for Metastatic Colorectal Cancer

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Abstract

Introduction

The authors report two cases of young patients who developed clubbing and hypertrophic osteoarthropathy in one case or lung diffusion disorder in the second, after a long-term use of bevacizumab plus chemotherapy in a palliative setting of metastatic colorectal cancer.

Discussion

We propose that patients on long-term bevacizumab be examined for clubbing and undergo respiratory function tests and that this would be studied prospectively before beginning trials in evaluating this monoclonal antibody given for 2 years in an adjuvant setting.

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References

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Authors and Affiliations

  1. Department of Medical Oncology, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042, Rennes, France

    Marc Pracht, Catherine Le Roux, Mallorie Kerjouan, Eveline Boucher & Jean-Luc Raoul

  2. Department of Medical Information, Comprehensive Cancer Center Eugène Marquis, Rennes, France

    Odile Audrain

Authors
  1. Marc Pracht
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  2. Catherine Le Roux
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  3. Mallorie Kerjouan
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  4. Eveline Boucher
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  5. Odile Audrain
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  6. Jean-Luc Raoul
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Corresponding author

Correspondence to Jean-Luc Raoul.

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Pracht, M., Le Roux, C., Kerjouan, M. et al. Clubbing and Hypertrophic Osteoarthropathy in Two Patients Taking Long-Term Bevacizumab for Metastatic Colorectal Cancer. J Gastrointest Canc 42, 176–178 (2011). https://doi.org/10.1007/s12029-010-9166-8

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  • DOI: https://doi.org/10.1007/s12029-010-9166-8

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