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A Complete Response in Small Cell Carcinoma of the Esophagus Treated by S-1/Cisplatin Combined Chemotherapy and Radiotherapy

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Abstract

Small cell carcinoma of the esophagus (SmCCE) is a rare disease which is considered to be more malignant than the most common types of esophageal cancer. The optimal treatment strategy for this disease still remains controversial. A 69-year-old male was diagnosed to have SmCCE (stage IIIA, T3N1M0). Due to the patient’s poor general condition, chemo-radiotherapy consisting of S-1/cisplatin therapy and a total of 60 Gy of radiotherapy was performed. After the treatment, the main lesion completely disappeared while some ulceration remained. A histological examination revealed no viable cancer cells in biopsy specimens obtained by endoscopy. Computed tomographic examinations showed a decreased wall thickness of the esophagus and an improvement in the swelling of the lymph nodes. S-1 monotherapy was administered following the main chemoradiation therapy, and it was performed for a total of 20 courses. The patient has been doing well without recurrence for over 3 years. We judged the effect to be a complete response. This combination chemo-radiotherapy with S-1 and cisplatin may therefore be one of the effective treatments against SmCCE.

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Authors and Affiliations

  1. Department of Surgery, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Masatsugu Hiraki, Masayuki Tanaka, Seiji Sato, Kiyoto Morito, Kiichiro Kobayashi, Hirokazu Noshiro & Kohji Miyazaki

  2. Department of Pathology and Biodefense, Saga University Faculty of Medicine, Saga, Japan

    Keita Kai & Osamu Tokunaga

Authors
  1. Masatsugu Hiraki
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  2. Masayuki Tanaka
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  3. Seiji Sato
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  4. Keita Kai
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  5. Kiyoto Morito
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  6. Kiichiro Kobayashi
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  7. Hirokazu Noshiro
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  8. Osamu Tokunaga
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  9. Kohji Miyazaki
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Correspondence to Seiji Sato.

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Hiraki, M., Tanaka, M., Sato, S. et al. A Complete Response in Small Cell Carcinoma of the Esophagus Treated by S-1/Cisplatin Combined Chemotherapy and Radiotherapy. J Gastrointest Canc 41, 275–280 (2010). https://doi.org/10.1007/s12029-010-9159-7

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  • DOI: https://doi.org/10.1007/s12029-010-9159-7

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