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Journal of Gastrointestinal Cancer

, Volume 41, Issue 4, pp 238–242 | Cite as

Primary Intra-abdominal Malignant Fibrous Histiocytoma: A Highly Aggressive Tumor

  • Nikolaos S. SalemisEmail author
  • Stavros Gourgiotis
  • Evangelos Tsiambas
  • Nikolaos Panagiotopoulos
  • Andreas Karameris
  • Efstathios Tsohataridis
Original Research

Abstract

Background and Purpose

Malignant fibrous histiocytoma (MFH) is the most common soft-tissue sarcoma of late adult life occurring predominantly in the extremities. Primary intra-abdominal MFH is a very rare occurrence. The aim of this study is to describe a very rare case of an intra-abdominal MFH with a highly aggressive clinical course.

Methods

A 67-year-old male was referred to our department with a 2-week history of dull lower abdominal pain and a gradually enlarging right lower abdominal mass, which he first noticed 2 months prior to admission. Computed tomography (CT) scan demonstrated a mass in the right iliac fossa.

Results

On exploratory laparotomy, a tumor was found in the right iliac fossa attached to the parietal lateral peritoneum without any evidence of invasion into the adjacent structures. Complete excision of the tumor with clear margins was performed. Histological and immunohistochemical examinations showed a MFH. One month after surgery, while on adjuvant chemotherapy, the patient was readmitted with dyspnea and a slightly palpable mass in the area of the previous radical resection. CT scan revealed local tumor recurrence along with multiple pulmonary metastatic deposits. Unfortunately, despite treatment, the patient died of progressive disease 5 weeks later.

Conclusions

Primary intra-abdominal MFH is a very rare but aggressive malignancy with a high tendency of local recurrence and metastatic spread. Early detection and complete surgical excision with clear margins is the treatment of choice. In some cases, however, the tumor can exhibit a highly aggressive clinical course despite radical surgery and adjuvant therapy.

Keywords

malignant fibrous histiocytoma abdominal aggressive tumor 

Notes

Acknowledgement

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Nikolaos S. Salemis
    • 1
    • 3
    Email author
  • Stavros Gourgiotis
    • 1
  • Evangelos Tsiambas
    • 2
  • Nikolaos Panagiotopoulos
    • 1
  • Andreas Karameris
    • 2
  • Efstathios Tsohataridis
    • 3
  1. 1.2nd Department of SurgeryArmy General HospitalAthensGreece
  2. 2.Department of PathologyArmy Veterans General HospitalAthensGreece
  3. 3.2nd Department of SurgeryArmy Veterans General HospitalAthensGreece

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